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Subthreshold Depression Linked to Inflammation and Altered Brain Connectivity

MHD card showing a side-view brain with a glowing crimson cingulate arc and a blood vessel releasing small red particles, illustrating a study in which university students with subthreshold depression had altered brain connectivity and slightly higher inflammatory proteins.

University students with subthreshold depression, meaning real depressive symptoms that fall short of a major depression diagnosis, had stronger connections in 3 cingulate brain circuits and slightly higher levels of 3 inflammatory proteins than healthy students, according to a 2026 brain-imaging study from China.1 Research Highlights Stronger cingulate connections: resting brain scans of 126 students …

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Chinese Herbal Acupoint Patches Improved Sleep After Stroke in Small Trials

MHD card with a glowing outline of the sole of a foot wearing a square herbal patch, a dotted amber meridian line, a crescent moon, and scattered dried berries and cinnamon pieces on a warm dark background, illustrating herbal acupoint patches for sleep after stroke.

A 2026 meta-analysis of 7 small Chinese trials found that adding herbal patches on acupuncture points to usual stroke care improved self-rated sleep in 608 stroke survivors with sleep problems.1 The researchers rated that evidence as very low certainty, and safety was barely reported. Research Highlights Better sleep scores: across 6 trials (536 people), Pittsburgh …

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Parcel-Guided rTMS for Treatment-Resistant Depression: 6 of 11 Remitted in Pilot

MHD card showing a dark violet mosaic of irregular brain-atlas parcels, with three highlighted parcels meeting at a glowing crosshair target beneath a figure-eight TMS coil, illustrating parcel-guided rTMS for treatment-resistant depression.

Researchers aimed repetitive transcranial magnetic stimulation (rTMS), which uses magnetic pulses to stimulate brain cells, at a spot chosen from each person’s own brain scan. In a small Columbia University pilot, 6 of 11 adults with treatment-resistant depression ended with low depression scores that met the trial’s remission threshold.1  Research Highlights Symptoms improved at the …

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Alzheimer’s Fingerprick Blood Biomarkers: p-tau217 and GFAP Track Cognition

MHD featured image for Alzheimer’s disease fingerprick blood biomarkers p-tau217 and GFAP.

A 2026 PROTECT study involving 174 older adults found that self-administered fingerprick p-tau217 correlated with episodic memory (r = 0.299, p < 0.001) and GFAP correlated with working memory (r = 0.183, p = 0.034), supporting remote Alzheimer's risk triage rather than a stand-alone dementia diagnosis. Research Highlights Fingerprick sampling reached 77% completion: 174 of …

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NREM2 Dreaming Preserved Subjective Sleep Depth in 1,024 Awakenings

MHD featured image for NREM2 dreaming and subjective sleep depth.

A 2026 PLOS Biology study using 256-electrode EEG and 1,024 NREM2 awakenings found that immersive dreaming predicted deeper subjective sleep, beta = 0.277, while reflective thought predicted shallower subjective sleep, beta = −0.195.1 Deep-feeling sleep can include immersive conscious experience. Research Highlights Immersion predicted depth: Perceptual immersion in NREM2 dreams was positively associated with subjective …

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Parkinson’s Visual Hallucination Mouse Model Hit AUC 0.96

MHD featured image for Parkinson's visual hallucination mouse model behavior classification.

A 2026 Parkinson’s disease mouse study reported that benzhexol hydrochloride induced a measurable hallucination-like behavior state in 6-OHDA parkinsonian mice, and an integrated behavior classifier separated that state from non-PDVH mice with AUC = 0.96 and Youden index = 0.875.1 The careful interpretation is behavioral modeling, not proof that mice had human visual hallucinations. Research …

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