A 2026 EEG study found that image memorability predicted recognition strongly, z = 9.17, p < 0.001, and the N400 encoding signal tracked memorability after later recognition success was included in the same model.1 The result weakens the common shortcut that every hit-vs-miss brain signal is purely an encoding-success signal. Research Highlights Memorability predicted recognition: …
A 76-person Nature Communications fMRI study found that people with major depressive disorder spent a higher share of time in a model-derived State 3 than healthy controls, 27.63 vs. 25.65, p(FDR) = 0.035, and State 3 occupancy correlated with QIDS depression severity, r2 = 0.268, p(FDR) = 0.008.1 The result points to altered brain-state transitions …
A 2026 neuron and mouse study found that CB1 receptors accumulate when autophagic flux is blocked, but p62 deficiency did not significantly increase steady-state CB1 receptor abundance in brain or hypothalamus and did not make CB1 signaling the primary explanation for late-onset obesity.1 The result separates 2 claims that are easy to blur: CB1 can …
The textbook story of social anxiety disorder is broken amygdala-prefrontal regulation — an overactive threat system the prefrontal cortex can’t calm down. A 2026 effective-connectivity study of 102 adults found something different: amygdala-prefrontal connectivity didn’t differ between social anxiety patients and controls, but connectivity between prefrontal regions did, particularly involving the pre-supplementary motor area.1 Research …
A 2026 meta-analysis of 32 randomized trials involving 2,669 participants found that ultrasound-guided acupotomy reduced chronic spinal musculoskeletal pain, with pain intensity improving by SMD = −0.80 and disability by SMD = −0.99 on NDI/ODI measures.1 The direction is favorable, but all trials came from China and evidence certainty stayed moderate for pain and low …
A 53-study resting-state functional magnetic resonance imaging (fMRI) meta-analysis found substance use disorder (SUD) linked to altered connectivity across prefrontal, striatal, thalamic, cingulate, and amygdala circuits. The most clinically relevant finding was an impulsivity correlation, not a diagnostic brain signature. Research Highlights Meta-analysis scale was meaningful: Zhang et al. pooled 53 whole-brain resting-state functional magnetic …
A 2026 adolescent depression study used resting-state functional magnetic resonance imaging to test whether childhood trauma leaves a measurable network signature in the depressed teen brain. The researchers found disrupted default-mode network hubs in teenagers with major depressive disorder and childhood trauma, and baseline functional-connectome patterns predicted treatment response with 82% accuracy.1 Research Highlights Large …