A 2026 automated MRI analysis of 153 adults with first cortical middle cerebral artery stroke found that remote deep gray nuclei changes were already measurable within 21 days, and 2 asymmetry markers independently predicted 3-month disability change: putamen volume Z-score asymmetry (β = −0.24; p = 0.021) and thalamic apparent diffusion coefficient asymmetry (β = …
An iScience EEG study found that approximately 80 minutes of natural smartphone use was interleaved with transient beta bursts, especially over bilateral sensorimotor cortex, and touchscreen intervals became longer when sensorimotor bursts were present.1 Research Highlights Natural smartphone behavior carried beta bursts: participants used smartphones with the right thumb for approximately 80 minutes while EEG …
A 2026 Molecular Psychiatry study found that oral FP802 disrupted the NMDAR/TRPM4 death complex and preserved memory-task performance in 5xFAD Alzheimer’s mice treated for 3 months.1 The finding is mechanistically sharper than a generic anti-amyloid claim: FP802 targeted a glutamate-toxicity complex downstream of amyloid stress. Research Highlights Complex formation was blocked: 5xFAD mice had increased …
In APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven clearance — a plausible mechanism, not a human treatment result yet.1 Research Highlights PTP1B loss improved behavior in APP/PS1 mice. Genetic deletion and DPM-1003 treatment improved novel object recognition and …
A 2026 CARDIOSA-12 secondary analysis found that active hypoglossal nerve stimulation improved sleepiness, insomnia, snoring, and sleep-related function, but objective cognitive test performance mostly did not improve compared with partially therapeutic stimulation.1 Symptom relief and measurable cognitive recovery answer separate clinical questions in treated obstructive sleep apnea. Research Highlights Subjective outcomes improved: active HGNS improved …
A 2026 Nature Communications mouse study tested 7,736 possible connections in the hippocampal CA3 memory circuit and found a developmental shift from dense early wiring toward sparse structured adult wiring: corrected CA3-to-CA3 connection probability fell from 6.37% at P7-8 to 2.17% at P45-50.1 The finding supports a circuit-level version of memory maturation, not a claim …
A 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopamine inputs from the VTA and substantia nigra to the LEC go functionally silent at the earliest disease stage in an APP knock-in mouse — before …