MentalHealthDaily

MIND Migraine Study Completed 3,688 Smartphone Cognition Assessments

by GLOOM

MHD featured image for the MIND migraine smartphone cognition feasibility cohort.

The MIND migraine feasibility study showed that remote migraine-cognition monitoring can produce a large daily dataset: 177 baseline participants completed 3,688 smartphone assessments, covering 70.8% of possible study days.1 The finding supports digital migraine endpoint infrastructure while leaving treatment effects and diagnostic thresholds untested. Research Highlights Daily monitoring was feasible: Participants completed 3,688 daily smartphone …

Migraine With PFO: Lower Indoleacrylic Acid, 211 Metabolite Changes

by GLOOM

MHD featured image for migraine with PFO metabolomics and indoleacrylic acid.

A 2026 iScience metabolomics study found 211 differentially expressed metabolites in migraine patients with patent foramen ovale; in a 220-person validation cohort, lower indoleacrylic acid plus hs-CRP reached AUC 0.722 for distinguishing migraine with PFO from controls.1 Research Highlights Metabolomics found a broad signal: The discovery cohort included 30 migraine-with-PFO patients and 17 controls, with …

Migraine Linked to Cognitive Impairment in Chinese MR

by GLOOM

Editorial card showing a brain with migraine pain pathways overlaid on genetic instrument schematic for Mendelian randomization.

A 2026 study by Bai et al. in Dialogues in Clinical Neuroscience uses Mendelian randomization (MR) — inherited genetic variants as a natural experiment to test causality — and concludes that migraines causally lower cognitive performance in a Han Chinese sample.1 The headline conclusion is plausible; the effect-size numbers in the popular MR shorthand (odds …

GPR30 and Migraine: Estrogen Link Still Lacks Human Trials

by GLOOM

MHD featured image for GPR30, estrogen signaling, trigeminal ganglion biology, and migraine.

A 2026 review argued that G protein-coupled receptor 30 may connect estrogen signaling, trigeminal pain pathways, and migraine biology, but migraine-specific human trials of GPR30-targeted drugs are still missing. Research Highlights The migraine rationale is hormone-linked: women have roughly 2 to 3 times the migraine prevalence of men, and 50% to 60% of women with …

Dialysis Headache in Hemodialysis: Prior Headaches Raise Odds 4.08x

by GLOOM

MHD featured image for dialysis headache risk factors in hemodialysis patients.

A 2026 cross-sectional study of 79 adults receiving hemodialysis found dialysis headache in 40 patients (50.6%), and a prior history of recurrent headaches was the strongest adjusted signal: OR = 4.08 (95% CI 1.42-11.75; p = 0.009). Research Highlights Dialysis headache was common: 40 of 79 hemodialysis patients met ICHD-3 criteria, putting frequency at 50.6% …

Anti-CGRP Monoclonal Antibodies to Prevent Chronic Migraine (2023 Review)

by GLOOM

Migraine, a primary headache disorder, significantly impacts the quality of life of millions worldwide. In recent years, the focus has shifted toward developing targeted therapies, particularly monoclonal antibodies (mAbs) against the calcitonin-gene-related peptide (CGRP), to prevent chronic migraine attacks. A relatively recent comprehensive network meta-analysis (NMA) evaluated the efficacy and safety of various anti-CGRP mAbs, …

Does MSG Cause Headaches? Monosodium Glutamate Research Reviewed

by GLOOM

Monosodium glutamate (MSG), commonly used as a flavor enhancer, has been controversially linked to headaches for decades. Key Facts: Human studies linking MSG to headaches have inconsistent findings, especially when MSG is consumed with food. Studies in which MSG reportedly causes headaches often have methodological flaws like inadequate blinding due to MSG’s strong taste. MSG …