Neurodegenerative Diseases Archives

ALS CSF Proteomics Found 399 Candidate Proteins and a 5-Protein Panel

by GLOOM

MHD featured image for ALS CSF proteomics and biomarker panels.

A 2026 cerebrospinal-fluid proteomics preprint involving 87 amyotrophic lateral sclerosis (ALS) patients, 89 healthy controls, and 61 neurological controls reported 399 ALS candidate proteins, complement markers that tracked disease stage, and a 5-protein panel that classified ALS vs. healthy controls with ROC AUC 0.95 after the best-known neurodegeneration markers were removed.1 Research Highlights CSF proteomics …

ALS Entropy Analysis Finds 5-Month Signal Hidden by ALSFRS Scores

by GLOOM

MHD featured image for ALS trial endpoints, Shannon entropy, and ALSFRS domain trajectories.

A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found a signal that ordinary ALSFRS total-score slopes cannot even express: Shannon entropy trajectories diverged between pooled active and placebo arms, including a 5-month delay in peak Fine Motor distributional spread for active-arm patients.1 Research Highlights Entropy found an endpoint-level signal: Rodriguez analyzed 7,512 …

Risperidone in Dementia Raised Stroke-Related Events 4.11x by Week 4

by GLOOM

MHD featured image for risperidone adverse events in dementia.

A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked risperidone to cerebrovascular adverse events, HR 4.11 (95% CI 1.77 to 9.51), and major cardiovascular adverse events, HR 2.00 (95% CI 1.23 to 3.26).1 The timing signal is the practical warning: median first cerebrovascular event appeared at 4.3 weeks, and median first major …

Parkinson’s Speech Pauses Track Sentence Complexity and MoCA Scores

by GLOOM

MHD featured image for Parkinson's speech pauses, sentence complexity, MoCA scores, and dysarthria.

A 2026 connected-speech study found that people with Parkinson’s disease produced more silent pauses than older controls while reading aloud: 2.185 vs. 1.595 mean pauses, while long sentences produced 2.676 pauses vs. 1.033 in short sentences.1 Within the Parkinson’s group, MoCA scores correlated with total pause count (rs = −0.502, p = 0.005). Research Highlights …

Clomipramine Improved Alzheimer’s Mouse Memory by Blocking Itch in 45 Days

by GLOOM

Editorial card showing clomipramine, Itch signaling, and Alzheimer's mouse-memory rescue with a molecular neuroscience background.

A 2026 iScience study found that 45 days of clomipramine improved spatial, working, and reference memory in female APP/PS1 Alzheimer’s-model mice, apparently by blocking the E3 ubiquitin ligase Itch rather than by clearing amyloid plaques.1 Research Highlights 45-day clomipramine signal: 6-month female APP/PS1 mice received 25 mg/kg clomipramine every other day for 45 days, then …

Stress Internalization Predicts Memory Decline in Older Chinese Americans

by GLOOM

Editorial card showing an older Chinese American adult and a memory-decline trajectory, illustrating the PINE cohort finding that stress internalization predicts cognitive decline.

A 2025 longitudinal analysis of 1,528 older Chinese Americans by Chen et al. in the Journal of Prevention of Alzheimer’s Disease says something more specific than “stress causes Alzheimer’s”: it isn’t the count of stressors that tracks memory decline — it’s a latent trait the authors call stress internalization, a bundle of high perceived stress, …

Statins and Dementia Risk: No Long-Term Signal in 322,358 Patients

by GLOOM

Statins do not look like a dementia-prevention drug, but they do not look like a dementia hazard either. In 322,358 Kaiser Permanente Northern California patients followed for an average of 11.8 years, dementia diagnoses rose right after statins were started, then flattened: after the first year, the hazard ratio for Alzheimer’s disease and related dementias …