A 2026 PROTECT study involving 174 older adults found that self-administered fingerprick p-tau217 correlated with episodic memory (r = 0.299, p < 0.001) and GFAP correlated with working memory (r = 0.183, p = 0.034), supporting remote Alzheimer's risk triage rather than a stand-alone dementia diagnosis. Research Highlights Fingerprick sampling reached 77% completion: 174 of …
A 2026 Parkinson’s disease mouse study reported that benzhexol hydrochloride induced a measurable hallucination-like behavior state in 6-OHDA parkinsonian mice, and an integrated behavior classifier separated that state from non-PDVH mice with AUC = 0.96 and Youden index = 0.875.1 The careful interpretation is behavioral modeling, not proof that mice had human visual hallucinations. Research …
A nationwide Finnish registry study found that 2 severe infection categories still predicted dementia after adjustment for 27 noninfectious comorbid diseases.1 Cystitis and bacterial infection of an unspecified site both had adjusted rate ratios of 1.19 after comorbidity adjustment, meaning the infection-dementia association did not disappear when prior hospital-treated illnesses were modeled. Research Highlights The …
A 2026 Nature Aging study involving 520 participants found that plasma protein-structure signatures classified healthy control, mild cognitive impairment, and Alzheimer’s disease groups with 83.44% three-way accuracy.1 The result is a serious biomarker signal, but it is not a clinic-ready replacement for established Alzheimer’s testing. Research Highlights Classification was strong: The plasma structural-proteomics panel reached …
A 2026 Glia analysis found a shared microglial transcriptional program across 5 neurodegenerative contexts: ALS, frontotemporal dementia, Alzheimer’s disease, aging, and Parkinson’s disease.1 The standout marker was SPP1, a gene encoding osteopontin, but the finding is a cellular-state signal rather than a ready diagnostic test. Research Highlights Cross-disease microglia converged: the integrated dataset covered ALS, …
A 5-year PPMI cohort analysis found that lower serum uric acid independently predicted incident depression in prodromal Parkinson’s disease (HR = 0.776; 95% CI 0.619-0.974; P = 0.029).1 The signal sits beside a lower-p-value non-motor symptom predictor: higher MDS-UPDRS Part I scores also predicted depression (HR = 1.177; 95% CI 1.093-1.267; P < 0.001). Research ...
A 2026 PLOS One computational study linked Trichostatin A to 949 predicted targets and 8 machine-learning-selected Alzheimer’s disease core genes, but 100 ns molecular dynamics simulations suggested the compound did not stably bind those candidate proteins.1 That makes the result more useful as an epigenetic network hypothesis than as evidence for a near-term Alzheimer’s drug. …