New research reveals that individuals with depression exhibit significantly higher levels of mitochondrial DNA (mtDNA) compared to healthy individuals. This suggests mtDNA could serve as a promising biomarker to improve depression diagnosis and treatment outcomes. Key facts: Meta-analysis of 12 studies with 1400 participants shows elevated mtDNA levels in blood and skin cells of depressed …
A 34-year-old man developed symptoms of frontotemporal dementia (FTD), a rare form of early-onset dementia, after using cannabis for two years. This case highlights the potential risks of long-term cannabis use on brain health, especially for vulnerable individuals. Key Facts: The 34-year-old man used cannabis for two years before experiencing personality changes and behavioral symptoms …
It is estimated that 40% of U.S. adults are obese – and this figure is projected to continue growing. One potential reason for weight gain and a possible catalyst for obesity is use of pharmaceutical drugs (i.e. medications). Medication-induced weight gain poses a significant challenge in healthcare, affecting both patient well-being and treatment adherence. Key …
Microplastics and nanoplastics (MNPs) from the breakdown of plastic materials pollute the environment and make their way into the human body, raising concerns over potential health impacts. Research shows that microplastics and nanoplastics are able to cross the blood-brain barrier in mice within 2 hours of ingestion. Key Facts: Polystyrene nanoparticles with a size of …
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental disorder characterized by developmentally inappropriate levels of inattention, hyperactivity, and impulsivity. While highly heritable, the heterogeneity of clinical presentation suggests complex interactions between genetic and environmental risk factors. A new study suggests that it may be possible to diagnose ADHD or detect ADHD susceptibility risk in children …
Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most common form of dementia. Research is ongoing to better understand AD pathogenesis and explore potential treatments. Genome editing tools like CRISPR/Cas9 offer new approaches to study and potentially treat AD. Key Facts: AD pathogenesis likely involves multiple genetic and environmental factors Gene mutations linked …
Stress can induce anxiety and depression, which appears to be mediated in part by stress-induced neuroinflammatory processes. The immunoregulatory bacterium Mycobacterium vaccae (M. vaccae) has anti-inflammatory and stress-resilient effects, but its impact on the brain is unclear. A study discovered that M. vaccae immunization: induces anti-inflammatory and immunoregulatory processes in the hippocampus, blocks stress-induced neuroinflammation …