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Risky Alcohol Use Doubled Aneurysm Rupture Odds; THC Signal Was Null

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A 2026 prospective German aneurysm cohort found risky alcohol use in 4.6% of 954 intracranial aneurysm patients, and that exposure carried 2.00x higher adjusted odds of aneurysm rupture plus 3.26x higher adjusted odds of clinically severe aneurysmal subarachnoid hemorrhage. Research Highlights Risky alcohol was the main signal: drinking above the study threshold was independently associated …

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Semaglutide Reduced Cocaine Choice in Rat Study

Semaglutide is not close to being an approved cocaine-use-disorder medication, but a 2026 rat study gives the idea a more demanding preclinical test than ordinary self-administration experiments. After 5 days of treatment, rats shifted away from cocaine choice without losing total operant responding, which separates the result from a broad appetite-suppression artifact. Research Highlights Semaglutide …

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Eutylone Inhibits CYP2D6 Like MDMA: Polydrug Interaction Risk

MHD featured image for eutylone, CYP2D6 inhibition, and polydrug interaction risk.

A 2026 cross-species metabolism study found that eutylone, a synthetic cathinone stimulant sometimes sold as a “bath salt” or MDMA-like drug, inactivated CYP2D6 with Ki = 4.2 μM, kinact = 0.069 min-1, and inactivation efficiency = 1.64 x 10-2 min-1 μM-1 — a range the researchers described as comparable to MDMA. Research Highlights CYP2D6 was …

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