A 2026 NHANES analysis of 6,502 adults found that urinary 3-PBA, a pyrethroid insecticide metabolite, was modestly associated with depression risk at OR = 1.02 per 1 μg/L, while self-reported household pesticide exposure weakened after full adjustment to OR = 1.43 (95% CI 0.91 to 2.25).1 The calibrated read is biomarker signal first, causal language …
A 2026 developing Human Connectome Project analysis of 438 full-term neonates found that the newborn cortex already had an adult-like folding hierarchy: gyri connected most strongly to other gyri, sulci connected most weakly to other sulci, and structure-function coupling shifted near 41 to 42 weeks postmenstrual age.1 Research Highlights Gyri were already high-connectivity hubs: across …
Lecanemab blood biomarkers may rebound much faster than amyloid PET after treatment stops: a 2026 PK/PD model estimated that half of the Aβ42/40 treatment effect is lost within 0.5 years, compared with 12.1 years for amyloid PET signal.1 Research Highlights 0.5-year rebound for Aβ42/40: Bhagunde et al. estimated that half of the Aβ42/40 treatment effect …
Some sleep apnea patients stay sleepy even when their CPAP is used 6+ hours a night and apnea events have been driven back to normal range. A 2026 cross-sectional study of 65 PAP-adherent adults found those residually sleepy patients performed measurably worse on global cognition, memory, executive function, attention, and processing speed than their well-rested …
A 2026 UK Biobank analysis by Aas et al. in BMC Medicine tests the “adversity leaves a fixed biological scar” framing against five biological aging markers in 153,557 middle-aged and older adults — and the marker that moves most reliably isn’t telomere length or any metabolomic clock.1 Research Highlights 153,557-participant test: Aas et al. measured …
A 2026 open-label feasibility trial involving 5 Parkinson’s disease patients found that app-randomized levodopa timing was associated with a mean 4.4-point improvement on the Unified Parkinson’s Disease Rating Scale, but the signal missed conventional statistical significance at p = 0.063.1 The narrow conclusion is feasibility: this was a dosing experiment that justified a blinded controlled …
A 2026 medRxiv preprint interviewed 15 health-system stakeholders about CARES, a freestanding addiction-risk screening platform, and found a clear implementation split: people wanted better substance-use prevention tools than current clinic screening, but provider burden, stigma, knowledge gaps, and medical-record liability could block uptake.1 Research Highlights Stakeholders saw a screening gap: all 15 interviewees held leadership …