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Treatment-Resistant Schizophrenia Affects 28.6% of Assessed Inpatients in Japan

MHD card with a 10-person pictogram in 2 rows on a dark amber background, 3 figures lit in orange, beside a key whose bow is a 2-tone capsule, illustrating that nearly 3 in 10 assessed inpatients in Japan had treatment-resistant schizophrenia.

A 2026 nationwide study in Japan found that 28.6% of hospitalized patients with schizophrenia who were checked for treatment resistance met the criteria.1 Nearly half of those patients left the hospital on clozapine, the only antipsychotic with established benefit for this form of the illness. Research Highlights Large real-world sample: records covered 18,914 inpatients discharged …

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Self-Harm Risk Was Highest Before ADHD Medication Started

MHD card showing a night sky over a dark mountain range with one steep peak outlined in gold and a small glowing lantern at its foot, illustrating that self-harm risk peaked before ADHD medication started.

Among people prescribed ADHD medication in 5 health systems, recorded self-harm was most common in the 3 months before their first prescription, not after it.1 Risk fell once treatment began but stayed a little above each person’s unmedicated baseline. Research Highlights Highest risk before the first prescription: in the 90 days before starting ADHD medication, …

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