A 2026 cross-sectional schizophrenia study found no meaningful association between antipsychotic dose and Montreal Cognitive Assessment (MoCA) performance in young, clinically stable outpatients. Cognitive scores related more strongly to symptom burden, illness duration, education, and age at diagnosis than to daily or 1-year cumulative antipsychotic exposure.1 Research Highlights Daily dose was not linked to MoCA: …
A 2026 case-control imaging study found that 23 women with premenstrual dysphoric disorder had higher left DTI-ALPS glymphatic index than 27 healthy controls (p = 0.024), plus wider hypothalamus connectivity across emotion and subcortical networks.1 The result adds a brain-fluid-clearance and stress-network layer to PMDD biology, but the evidence is still small-sample imaging rather than …
A 2026 national survey of Dutch emergency physicians found wide variation in first-line medication choices for extreme agitation: without intravenous access, 34.7% preferred midazolam, 23.1% preferred droperidol, 14.3% preferred droperidol plus midazolam, and 10.4% preferred esketamine.1 The result is a practice map, not an outcome trial, but it shows how emergency clinicians are balancing rapid …
Subthalamic deep brain stimulation (STN-DBS) gives most patients with advanced Parkinson’s disease meaningful motor relief, but a subset develops new or worsened impulse control disorders — pathological gambling, compulsive shopping, hypersexuality, binge eating — while others see preexisting symptoms improve. A 2026 prospective preprint from Loehrer et al. used pre-surgical diffusion MRI to identify microstructural …
Restless legs syndrome (RLS) and opioid-withdrawal restlessness both produce night-worsening urges to move. A 2026 npj Parkinson’s Disease mouse study tied that overlap to hypersensitive striatal D1-mu-opioid receptor signaling in basal-ganglia motor circuits.1 Research Highlights 2 clinically similar states converged: restless legs syndrome and opioid-withdrawal restlessness both point toward a striatal D1-mu-opioid circuit that regulates …
The structural determinants of mental health get less air time than individual treatments, but a 2025 CDC analysis of 3,121 US counties from Bolduc et al. shows just how much county-level economics moves population mental health: a model built from 11 economic variables explains roughly 70% of the variation in adult poor-mental-health prevalence across the …
A 2026 functional magnetic resonance imaging study involving 54 adults found that pairing a formerly threatening cue with positive images, a laboratory method called counterconditioning, strengthened later neural safety-memory signals in people with posttraumatic stress disorder. The experiment measured fear-learning biology, not PTSD symptom improvement after therapy.1 Research Highlights 54 adults were analyzed: Cooper et …