Mental Health Daily

Prostate Cancer Survivors Who Smoke Showed Lower Verbal Memory Scores

by GLOOM

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A 2026 study involving 118 prostate cancer survivors found the clearest lifestyle-cognition signal around smoking: smokers learned fewer words across repeated verbal-memory trials, while obesity and physical activity produced narrower reaction-time findings and no significant anxiety or depression differences. Research Highlights Smoking tracked verbal learning: in 118 prostate cancer survivors, smokers scored lower on Verbal …

Multiple Sclerosis Iron MRI Linked to Cognitive Impairment in 12 Studies

by GLOOM

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A 2026 systematic review of advanced neuroimaging in multiple sclerosis narrowed 600 database records to 12 studies and found the clearest cognition signal in basal ganglia iron-sensitive MRI measures, while thalamic susceptibility was more variable and often tangled with atrophy. Research Highlights Basal ganglia signal was strongest: across 12 studies, elevated susceptibility or iron-related metrics …

Eating Disorder Hospital Discharge: 70 Clinicians Flag Outpatient Care Gaps

by GLOOM

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A 2026 Australian co-design study found that 70 of 73 surveyed health professionals, plus all 5 people with lived experience and all 6 carers interviewed, described outpatient care after eating-disorder hospital discharge as inadequate. Research Highlights Outpatient care was the main gap: 70 of 73 surveyed health professionals and all 11 interviewed patients/carers said care …

ME/CFS Memorial Entries: 505 Death Narratives Show Suicide Risk Gaps

by GLOOM

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystem illness marked by post-exertional malaise, cognitive dysfunction, pain, sleep disruption, and autonomic symptoms; a 2026 PLOS One qualitative analysis of 505 memorial entries found that bereaved accounts repeatedly placed death inside 4 overlapping contexts: systemic neglect, clinical dismissal, social disconnection, and personal functional collapse.1 Research Highlights …

Tau Oligomers Disrupted Nuclear Lamina in Alzheimer’s Disease Models

by GLOOM

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A 2026 Acta Neuropathologica study found that oligomeric tau was linked to early nuclear lamina disruption in Alzheimer’s disease tissue, PS19 tauopathy mice, and human induced pluripotent stem cell (iPSC)-derived neurons.1 The strongest claim is mechanistic: tau oligomers appeared to deform the nuclear envelope and disturb chromatin before overt neurodegeneration, but the work does not …

NDST3 Suppression Restores Lysosome Acidity in Alzheimer’s Mouse Models

by GLOOM

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A 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH in APP695Swe neuronal cells from 5.6 back below 5.0, then reduced amyloid-β, MAPT/tau pathology, neuronal injury, and memory deficits in 3xTg-AD mice.1 Research Highlights Lysosome pH moved back down: APP695Swe-overexpressing HT22 cells had lysosomal pH around 5.6, while NDST3 knockdown re-acidified lysosomes to …

C9orf72 ALS Poly-GR Drives Ferroptosis via Nrf2-Slc7a11

by GLOOM

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A 2026 Cell & Bioscience study found that poly-GR, one of the toxic dipeptide-repeat proteins produced in C9orf72-linked amyotrophic lateral sclerosis (ALS), pushed motor neuron-like cells toward ferroptosis: 4-HNE lipid peroxidation rose at p < 0.0001, labile Fe²+ rose at p < 0.001, and erastin caused more cell death in poly-GR-expressing cells than in control …