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REDDI MEG Classifier Separated 4 Neurodegenerative Diseases at 0.81

MHD featured image for REDDI MEG differential diagnosis research.

A 2026 medRxiv preprint found that REDDI, a resting-state magnetoencephalography machine-learning pipeline, separated mild cognitive impairment, multiple sclerosis, Parkinson’s disease, and amyotrophic lateral sclerosis with 0.81 ± 0.04 balanced accuracy across 5 folds.1 That is a meaningful jump over the prior 67.1% MEG benchmark, but it is still research-stage decision support rather than a clinical …

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Antrodia Silver Nanoparticles Reduced Parkinsonism Markers in 63 Rats

MHD featured image for Antrodia silver nanoparticles and Parkinsonism oxidative-stress markers.

A 2026 Parkinsonism study involving 63 male rats found that Antrodia cinnamomea plus citrate-stabilized silver nanoparticles reduced 6-OHDA motor, oxidative-stress, inflammatory, α-synuclein, and apoptosis markers, while dopamine and acetylcholine recovery remained nonsignificant. The useful claim is a multitarget preclinical signal, not a Parkinson’s disease treatment recommendation. Research Highlights Combination treatment looked strongest: Tekiner et al. …

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AI Suicide-Risk Agent Detected 91.5% vs. ChatGPT Health

MHD featured image for AI suicide-risk safety-agent research.

A 2026 preprint found that an independent supervisory safety agent detected suicide-risk signals in 205 of 224 synthetic evaluations, compared with 41 of 224 for native ChatGPT Health crisis safeguards.1 The result is a strong benchmark signal for external monitoring, not proof that AI systems can safely manage suicidal patients without human oversight. Research Highlights …

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Women With Problematic Sexual Behavior Had Higher NSSI Risk

MHD featured image for non-suicidal self-injury and problematic sexual behavior.

A 2026 preprint combining 2,189 university participants with 477 clinical patients with problematic sexual behavior found a gender-specific self-harm signal: women with problematic sexual behavior had higher non-suicidal self-injury risk, but clinical severity of problematic sexual behavior did not predict NSSI inside the patient cohort.1 Research Highlights Total sample was 2,666 people: Jiang et al. …

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Alpha-Synuclein SAA Detected 95% of Lewy Body Dementia in ALZAN

MHD featured image for alpha-synuclein SAA and Lewy body dementia biomarkers.

A 2026 ALZAN memory-clinic cohort found that cerebrospinal-fluid alpha-synuclein seed amplification assay detected 19 of 20 Lewy body dementia cases, with 95% sensitivity and 93.5% specificity against non-Lewy-body, non-Alzheimer’s controls.1 The same assay was positive in 32 of 203 Alzheimer’s disease patients, which makes the result a co-pathology warning as much as a diagnostic win. …

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Single-Session tDCS Fails Working-Memory Test in Schizophrenia

Stylized illustration of tDCS electrodes positioned over the right dorsolateral prefrontal cortex on a brain outline, with a pre-post working-memory task in the foreground, representing the null-result trial in schizophrenia.

Transcranial direct current stimulation (tDCS) has been pitched as a scalable cognitive-enhancement tool for schizophrenia, where roughly 98% of patients show working-memory deficits, but a 2026 sham-controlled crossover trial from Ke et al. delivered the standard 1.5 mA anodal protocol over the right DLPFC to 27 stable patients and found no detectable benefit over sham.1 …

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