A 2026 psychometric study of 354 Swedish participants found that 1-week versions of the PHQ-15 and SSD-12 mostly preserved internal consistency and construct validity, but reliability was acceptable mainly in clinical participants or when researchers averaged 2 timepoints. Research Highlights Clinical tracking looked more defensible than healthy screening: Hybelius et al. studied 194 people with …
A 2026 ABCD Study preprint involving 11,868 youth found stable time-ordered predictors of teen substance-use initiation, but the adjusted effects were small: most estimates ranged from −0.01 to 0.02 initiation-probability points per 1-SD predictor increase. Research Highlights Large ABCD panel: Wei et al. analyzed 11,868 youth with repeated observations and interval-level initiation outcomes for alcohol, …
A 2026 iScience study found that 45 days of clomipramine improved spatial, working, and reference memory in female APP/PS1 Alzheimer’s-model mice, apparently by blocking the E3 ubiquitin ligase Itch rather than by clearing amyloid plaques.1 Research Highlights 45-day clomipramine signal: 6-month female APP/PS1 mice received 25 mg/kg clomipramine every other day for 45 days, then …
A 2026 two-experiment study found no visual-working-memory benefit from parietal or occipital transcranial direct current stimulation, while distraction unexpectedly made the cardinal-over-oblique orientation advantage stronger than it was without distraction: the pooled distraction-by-angle interaction had BFinc = 1021.671.1 Research Highlights Distraction strengthened the bias: pooled data from 68 analyzed adults showed a strong distractor-by-angle interaction, …
A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% in controls (p = 0.009), while MTHFR promoter methylation was nearly saturated in both groups (95.00% vs. 90.00%; p = 1.000). Research Highlights Genetic …
A 2026 first-in-human medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation shortened stimulated seizures by 52% on average and reduced seizure incidence by 80.9% after 48 hours in 5 high-frequency therapy-resistant epilepsy patients. The signal is promising because it combines responsive seizure detection with electrode strips placed under the scalp rather than electrodes implanted …
A 2026 secondary analysis of the HomePAP trial found that each 10 L/min more unintentional CPAP mask leak was associated with 26.6 fewer PAP minutes per night and 7.2 percentage-point fewer adherent days, but the new Real Leak metric did not significantly outperform ordinary device-reported Average Leak.1 Research Highlights Real Leak tracked poorer adherence: each …