Celecoxib for Depression: 7 Trials, Add-On Benefit Unclear
A 7-trial review favored adding celecoxib to antidepressants for depression, but its benefit was not confirmed after 3 high-risk trials were excluded.
Adult ADHD Trials Often Skip Full Diagnostic Assessment
A 2025 scoping review of 292 adult ADHD randomized controlled trials found that 49.7% allocated diagnosis without a general psychopathology assessment, and only 35% reported that psychiatrists or psychologists assigned the ADHD diagnosis. Research Highlights 292 adult ADHD RCTs were reviewed: Studart et al. screened 706 PubMed records and included 292 randomized controlled studies.1 49.7% …
Alzheimer’s Fingerprick Blood Biomarkers: p-tau217 and GFAP Track Cognition
A 2026 PROTECT study involving 174 older adults found that self-administered fingerprick p-tau217 correlated with episodic memory (r = 0.299, p < 0.001) and GFAP correlated with working memory (r = 0.183, p = 0.034), supporting remote Alzheimer's risk triage rather than a stand-alone dementia diagnosis. Research Highlights Fingerprick sampling reached 77% completion: 174 of …
Antidepressants Did Not Shift Facial Emotion Recognition in Depression
A 2026 ANTLER mechanistic analysis found no evidence that maintaining antidepressants preserved a happier facial-emotion recognition pattern compared with placebo substitution at 12 weeks (adjusted mean difference 0.23, 95% CI −0.5 to 1.0, p = 0.5) or 52 weeks (0.29, 95% CI −0.5 to 1.2, p = 0.5). Research Highlights No 12-week maintenance advantage: discontinuation …
Female Body Size Judgments Depend on Lower-Body Visual Cues
A 2-experiment BMC Biology study found that female body-size judgments did not require a full-body view: bottom-half views preserved accuracy in 99 women, while isolated inner- or outer-thigh views produced more perceptual error than whole-body views in a second 116-woman experiment.1 The result is relevant to body-image research because it points to lower-body feature integration, …
NREM2 Dreaming Preserved Subjective Sleep Depth in 1,024 Awakenings
A 2026 PLOS Biology study using 256-electrode EEG and 1,024 NREM2 awakenings found that immersive dreaming predicted deeper subjective sleep, beta = 0.277, while reflective thought predicted shallower subjective sleep, beta = −0.195.1 Deep-feeling sleep can include immersive conscious experience. Research Highlights Immersion predicted depth: Perceptual immersion in NREM2 dreams was positively associated with subjective …
Parkinson’s Visual Hallucination Mouse Model Hit AUC 0.96
A 2026 Parkinson’s disease mouse study reported that benzhexol hydrochloride induced a measurable hallucination-like behavior state in 6-OHDA parkinsonian mice, and an integrated behavior classifier separated that state from non-PDVH mice with AUC = 0.96 and Youden index = 0.875.1 The careful interpretation is behavioral modeling, not proof that mice had human visual hallucinations. Research …