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Late-Diagnosed PKU Linked to Depression in Children

MHD featured image for depression and quality of life in children with phenylketonuria.

A 2026 Egyptian study of 76 children found a sharp mental-health gradient in phenylketonuria (PKU): late-diagnosed children had higher depression scores, lower quality of life, lower IQ, and a 21.4% rate of reported suicidal thoughts. Early-diagnosed children still differed from controls on some functioning measures, but the late-diagnosed group carried the heaviest psychiatric and cognitive …

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SMART Texts Raised Diabetes Confidence in Schizophrenia

MHD featured image for SMART text messages and diabetes self-management in schizophrenia.

A 12-week text-message intervention for people with schizophrenia spectrum disorders improved diabetes self-management confidence and patient activation, but it did not yet move weight, HbA1c, physical activity, or psychiatric symptoms. SMART looked feasible and psychologically useful in this uncontrolled pilot; cardiometabolic outcomes need a full-scale randomized trial with longer follow-up.1 Research Highlights SMART was tested …

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Early Clozapine in Schizophrenia: 34% Lower Relapse Risk

Stylized illustration of a stopwatch overlaying schizophrenia treatment-stage icons, representing the multi-year delay before clozapine is offered to patients who already meet treatment-resistance criteria.

Clozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years — a “third-line, after years of failure” default that a 2026 Current Opinion review by Davani et al. argues is no longer supported by the evidence.1 …

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Music During Ketamine Did Not Improve Resistant Depression

MHD featured image for ketamine psychotherapy, treatment-resistant depression, music, and psychedelic-like treatment context.

Adding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participants to groups by chance), even though the full 6-infusion ketamine-psychotherapy course was followed by large depression-score reductions. Research Highlights Music added no confirmed MADRS benefit: in the MUSIK …

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