A 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal channel relevant to Parkinson’s risk biology.1 Acidifying the luminal side from pH 7.4 to 4.7 activated proton conductance, shifted reversal potential, and tied H57 to H+ and K+ flux. Research Highlights Acidification activated TMEM175: lowering luminal-side pH from 7.4 to 4.7 increased inward …
A pilot randomized trial involving 71 refugees with posttraumatic stress disorder found large symptom improvement after narrative exposure therapy-based care, but adding refugee-adapted emotion-regulation training before narrative exposure therapy did not outperform supportive problem-solving before narrative exposure therapy in the full sample.1 Research Highlights 71 refugees were randomized: 35 received STAIR-R plus narrative exposure therapy, …
A 2026 mechanistic study involving 28 healthy adults found that a single 25 mg psilocybin session changed acute brain entropy, psychological insight, well-being, cognitive flexibility, and some MRI-derived white-matter signals for up to 1 month. Research Highlights Acute brain entropy rose clearly: 25 mg psilocybin increased Lempel-Ziv complexity (LZc; a measure of signal irregularity) at …
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores showed distinct resting facial action-unit patterns: AU10 upper lip raiser, AU23 lip tightener, and AU28 lip suck differed after correction in 45 analyzable participants.1 The result supports facial-expression screening research, but it does not show that a face video can diagnose MCI or …
A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy young adults, healthy older adults, and Parkinson’s disease patients, p = 0.0032, while gamma efficiency-sympathetic coupling differed at p = 0.0003.1 The main claim is that motor, cognitive, and autonomic physiology may be coupled tightly enough to deserve biomarker-level study. Research Highlights Brain-heart …
A 147-person feasibility randomized trial found that both a structured AI therapy chatbot and general ChatGPT reduced PHQ-9 depression scores compared with assessment-only control, with effect sizes of d = −0.47 and d = −0.44.1 The purpose-built therapy bot did not significantly outperform ChatGPT on depression, anxiety, impairment, or wellbeing. Research Highlights Both chatbots reduced …
A 2026 Nature single-neuron study recorded 3,109 medial temporal lobe neurons from 16 neurosurgical epilepsy patients and found that human item-context memory mostly used separate item and context populations: 597 stimulus-modulated neurons, 200 context-modulated neurons, and only 50 neurons that encoded specific picture-question combinations.1 The result argues against a simple “one cell stores the whole …