Mental Health Daily

Parkinson’s Balance Study Finds Cortical-Latency Muscle Control at 215 ms

by GLOOM

MHD featured image for cortical balance control in Parkinson's disease.

A 36-person Parkinson’s disease balance study found that perturbation-evoked muscle activity could be split into brainstem-latency LLR1 responses around 116-119 ms, cortical-latency LLR2 responses around 200-215 ms, and an antagonist destabilizing component around 173-181 ms.1 Parkinson’s disease lowered clinical balance scores, but the broad claim that Parkinson’s patients had higher cortical-latency LLR2 responses than older …

TMEV Viral Parkinson’s Mouse Model Caused 20-Week Dopamine-Lesion Behaviors

by GLOOM

MHD featured image for a viral Parkinson's mouse model using Theiler's murine encephalomyelitis virus.

A 2026 mouse study found that Theiler’s murine encephalomyelitis virus (TMEV) injected into the substantia nigra produced persistent Parkinson’s-like motor signals through 20 weeks, including apomorphine-induced rotations at every measured post-injection timepoint.1 The finding makes TMEV a useful viral-neuroinflammation model of dopamine-neuron injury, but it does not show that Theiler’s virus causes human Parkinson’s disease. …

Parkinson’s Diabetes Oxidative Stress: 8-OHdG Rose, F2-Isoprostanes Did Not

by GLOOM

MHD featured image for Parkinson's disease, diabetes, oxidative stress, 8-OHdG, and F2-isoprostanes.

A 2026 meta-analysis of 54 human studies found that 8-hydroxy-2′-deoxyguanosine rose in Parkinson’s disease, while F2-isoprostanes did not show a statistically confirmed Parkinson’s signal; type 2 diabetes showed much larger peripheral oxidative-stress elevations than Parkinson’s disease for both biomarkers. Research Highlights Parkinson’s DNA-oxidation signal was moderate: Msigwa et al. pooled 5 Parkinson’s disease studies with …

Acupuncture for Menopause Depression: Korean Cohort Found No QALY Gain

by GLOOM

MHD featured image for acupuncture and cost-utility in menopause depression care.

A 2026 Korean claims analysis of 32,941 women with menopausal disorders found that traditional Korean medicine without recorded acupuncture claims had the lowest 3-year cost and the highest mean quality-adjusted life-year estimate, while acupuncture-inclusive or Western-medicine-inclusive strategies cost more and produced slightly lower QALYs. Research Highlights Lowest-cost group also had the highest QALYs: traditional Korean …

Umbilical Cord Exosomes Reduced ICH Neuroinflammation in Rats

by GLOOM

MHD featured image for umbilical cord exosomes and intracerebral hemorrhage neuroinflammation.

A 2026 rat and astrocyte study found that human umbilical cord mesenchymal stem cell exosomes given 6 hours after experimental intracerebral hemorrhage reduced pro-inflammatory signaling and improved neurological recovery scores through the PI3K/AKT/PKM2/H3K18la pathway.1 The result is a mechanistic preclinical signal, not an emergency treatment for human brain hemorrhage. Research Highlights Exosomes were timed early: …

Schizophrenia MRI Subtypes Split 3,958 Patients Into 2 Patterns

by GLOOM

MHD featured image for schizophrenia MRI cortical-gradient subtypes.

A 2026 ENIGMA structural MRI preprint involving 3,958 people diagnosed with schizophrenia and 5,489 controls found 2 cortical-alteration subtypes rather than 1 uniform brain pattern.1 The result maps heterogeneity: anterior-cingulate and temporoparietal network patterns may separate patients, but the result is not a diagnostic MRI test. Research Highlights Large MRI base: The analysis included 3,958 …

Krabbe Disease Base Editing: 0.5% DNA Correction Improved Mice

by GLOOM

MHD featured image for base editing of GALC in Krabbe disease mice.

A 2026 twitcher-mouse study found that adenine base editing corrected only about 0.5% of genomic DNA and 5% of mRNA in a Krabbe disease model, yet that low editing signal restored GALC enzyme activity to about 5% of wild-type levels and reduced psychosine by about 47%.1 This mouse experiment shows why even small correction fractions …