A 2026 exploratory analysis of the ABCD cancer dyspnea trial found that higher baseline cytokines predicted less placebo symptom improvement than lower baseline cytokines across 33 of 40 cytokine-symptom combinations at day 7 and 29 of 40 at day 14.1 The signal is not ready for clinical prediction, but it sharpens a trial-design problem: patients …
A 2026 randomized trial in 63 adults with type 2 diabetes found that progressive muscle relaxation was linked to a large fatigue drop in the intervention group, from a Fatigue Severity Scale mean of 51.58 to 34.12, but adjusted between-group tests did not confirm a clear advantage over control for fatigue or sleep quality.1 The …
A 2026 SEEearly baseline report found that 53.3% of 184 young people with early schizophrenia-spectrum psychosis were not in employment, education, or training at study entry, even though 97.8% had at least a lower- or upper-secondary school-leaving qualification.1 Psychosis had already interrupted the bridge from school into training, college, or competitive work. Research Highlights NEET …
A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found a signal that ordinary ALSFRS total-score slopes cannot even express: Shannon entropy trajectories diverged between pooled active and placebo arms, including a 5-month delay in peak Fine Motor distributional spread for active-arm patients.1 Research Highlights Entropy found an endpoint-level signal: Rodriguez analyzed 7,512 …
A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked risperidone to cerebrovascular adverse events, HR 4.11 (95% CI 1.77 to 9.51), and major cardiovascular adverse events, HR 2.00 (95% CI 1.23 to 3.26).1 The timing signal is the practical warning: median first cerebrovascular event appeared at 4.3 weeks, and median first major …
A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …
A 2026 connected-speech study found that people with Parkinson’s disease produced more silent pauses than older controls while reading aloud: 2.185 vs. 1.595 mean pauses, while long sentences produced 2.676 pauses vs. 1.033 in short sentences.1 Within the Parkinson’s group, MoCA scores correlated with total pause count (rs = −0.502, p = 0.005). Research Highlights …