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rTMS Plus Risperidone Improved Schizophrenia Cognition

A 2026 randomized study involving 80 people with schizophrenia found that adding high-frequency repetitive transcranial magnetic stimulation to risperidone improved PANSS cognitive-factor scores and aggressive-behavior ratings more than risperidone alone over 4 weeks.1 Research Highlights Design was randomized but short: 80 patients were assigned to risperidone alone or risperidone plus rTMS, 40 per group, with …

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Workplace Mental Health Apps Split Outcomes: Anxiety Down, Wellbeing Up

MHD featured image for workplace mental health apps and executive-function training.

A 228-person randomized trial found a split result for workplace mental-health apps: executive-function training reduced anxiety and depressive symptoms at 12-week follow-up, while a self-guided CBT app improved workplace wellbeing without reducing symptoms.1 The mechanism claim was weaker than the outcome claim because measured executive-function change did not explain the improvements. Research Highlights 228 adults …

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Nighttime Caffeine Increased Impulsivity Through Dopamine in Fly Study

MHD featured image for nighttime caffeine, dopamine, and impulsive motor behavior.

A 2025 iScience study found that nighttime caffeine increased motor impulsivity in Drosophila, with dose-dependent loss-of-inhibition events across n = 30-32 flies per behavioral condition and stronger effects in female flies than male flies.1 The result does not prove that an evening coffee makes humans reckless, but it sharpens a neglected point: caffeine’s alertness benefit …

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Exercise Before CBT Raised Depression Remission to 69% in Pilot Trial

MHD featured image for exercise priming before CBT in major depression.

A 40-person pilot trial found depression remission in 69% of adults who did 30 minutes of moderate exercise before individual CBT, compared with 33% of adults who did a calming pre-CBT activity.1 Compared with a broad “exercise boosts therapy” claim, acute exercise is a plausible priming step; the alliance and activation mechanisms still need a …

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Arts Prescription Helped Young Adults Build Routine but Caused Stress

MHD featured image for arts on prescription and young-adult mental health.

A 2026 qualitative study of a 10-week Danish Arts on Prescription program found that young adults aged 18 to 30 often described more stable daily routine, confidence, and belonging, but some activities also caused stress, fatigue, or discomfort.1 The useful interpretation is structured creative groups may help some disconnected young adults rebuild daily life when …

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Chemotherapy Neuropathy Links Pain and Chemobrain Mechanisms

MHD featured image for chemotherapy neuropathy, pain, and chemobrain mechanisms.

A 2026 neuroscience review argues that chemotherapy-induced peripheral neurotoxicity should not be treated as a purely peripheral nerve problem: CIPN affects 70-90% of patients during chemotherapy, persists chronically in 20-30% of survivors, and may interact with central sensitization, pain networks, mood, sleep, and chemobrain.1 The strongest claim is mechanistic connection, not proof that neuropathy alone …

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Early Parkinson’s Non-Motor Symptoms Differed by Sex After Levodopa

MHD featured image for Parkinson's non-motor symptom sex differences.

A 2026 multicenter Italian cohort followed 216 early Parkinson’s disease patients for 24 months after levodopa initiation and found sex/gender differences in non-motor symptom burden.1 Women had higher anxiety, pain, mobility, and emotional-well-being burden, while men had higher hypersexuality. Research Highlights Longitudinal sample: The study followed 216 early levodopa-naive Parkinson patients, including 139 men and …

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