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CARES Addiction Risk Screening: 15-Stakeholder Preprint

MHD featured image for CARES addiction risk screening implementation.

A 2026 medRxiv preprint interviewed 15 health-system stakeholders about CARES, a freestanding addiction-risk screening platform, and found a clear implementation split: people wanted better substance-use prevention tools than current clinic screening, but provider burden, stigma, knowledge gaps, and medical-record liability could block uptake.1 Research Highlights Stakeholders saw a screening gap: all 15 interviewees held leadership …

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Accelerated tDCS Reduced Pain in 4 of 5 Bodily Distress Disorder Cases

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A 2026 case series of 5 adults with bodily distress disorder found mean pain scores decreased from 9.0 to 3.8 after accelerated transcranial direct current stimulation, with 4 of 5 patients achieving at least 50% pain reduction.1 The result is a feasibility signal, not proof of efficacy, because every patient knew they were receiving stimulation …

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Non-Invasive Prehabilitation Shifted Brain Tumor Language Networks

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A 2026 brain tumor prehabilitation study involving 26 surgical patients found that language-targeted non-invasive stimulation plus intensive language training shifted fMRI language activation away from the stimulation target, while measured language and cognition stayed stable. Research Highlights Language-targeted prehabilitation moved the fMRI signal: the group-by-time interaction for stimulation-target overlap was significant, F(1,23) = 4.61, p …

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Migraine With PFO: Lower Indoleacrylic Acid, 211 Metabolite Changes

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A 2026 iScience metabolomics study found 211 differentially expressed metabolites in migraine patients with patent foramen ovale; in a 220-person validation cohort, lower indoleacrylic acid plus hs-CRP reached AUC 0.722 for distinguishing migraine with PFO from controls.1 Research Highlights Metabolomics found a broad signal: The discovery cohort included 30 migraine-with-PFO patients and 17 controls, with …

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Autistic Children Matched Navigation Tasks but Rated Their Ability Lower

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A 2026 medRxiv preprint found that 26 autistic children performed similarly to 25 typically developing children on objective SPACE navigation tasks, contrary to the prediction, while autistic children rated their own navigation ability lower on the Santa Barbara Sense of Direction scale.1 Research Highlights Objective performance did not separate groups: 26 autistic children and 25 …

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OCD DBS Reduced Y-BOCS 42.9% as GPe Alpha Activity Decreased

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A 2026 medRxiv preprint found that 10 severe obsessive-compulsive disorder patients treated with anterior-limb-of-internal-capsule DBS had a 42.9% average Y-BOCS symptom decrease over 6 months while alpha-band activity in the anterior globus pallidus externus fell.1 The strongest read is a response-marker signal: GPe alpha decreased during effective OCD DBS, but the sample is too small …

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