A 2026 medRxiv preprint found that a training-free speech biomarker tracked dysarthria severity across 890 speakers, 10 corpora, and 5 full-pipeline languages, with all 5 consonant d-prime features showing random-effects correlations with clinical severity (rho = −0.50 to −0.56; all p < 2e−4). Research Highlights Speech-severity signal was broad: Muller et al. evaluated 890 speakers …
A 2026 medRxiv case-control study found that serum myelin oligodendrocyte glycoprotein was 20.5 pg/ml higher in multiple sclerosis than in healthy donors and 15.3 pg/ml higher during relapse than remission, making it a plausible blood marker of demyelination rather than a replacement for neurofilament light chain. Research Highlights MOG was higher in MS: serum myelin …
A 2026 medRxiv study of 30 adults with drug-resistant focal epilepsy found that dynamic FDG-PET had higher model-adjusted signal quality than static PET in most brain regions, including >80% posterior probability of superiority in 29 of 36 regions. Research Highlights Dynamic PET beat static PET: interictal dynamic FDG-PET showed higher signal quality than static PET …
A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite used as a proxy for overnight melatonin secretion, found 0 genome-wide significant loci in 11,744 people, even though 23 variants reached suggestive significance and 8 were supported by 2 analytic methods. Research Highlights No common variant dominated: the 2026 GWAS meta-analysis involving 11,744 …
A 2026 mixed-methods study of 32 chronic non-cancer pain patients found the strongest satisfaction signal when prescribed cannabis-based medicines affected stress, sleep, coping, anxiety, appetite, and daily function — not pain intensity alone.1 Research Highlights 32 patients were interviewed: Pombeiro Stein et al. studied adults from a German pain clinic who had used physician-prescribed cannabis-based …
A 2026 cross-sectional study of 79 adults receiving hemodialysis found dialysis headache in 40 patients (50.6%), and a prior history of recurrent headaches was the strongest adjusted signal: OR = 4.08 (95% CI 1.42-11.75; p = 0.009). Research Highlights Dialysis headache was common: 40 of 79 hemodialysis patients met ICHD-3 criteria, putting frequency at 50.6% …
A 2026 prospective German aneurysm cohort found risky alcohol use in 4.6% of 954 intracranial aneurysm patients, and that exposure carried 2.00x higher adjusted odds of aneurysm rupture plus 3.26x higher adjusted odds of clinically severe aneurysmal subarachnoid hemorrhage. Research Highlights Risky alcohol was the main signal: drinking above the study threshold was independently associated …