Auditory targeted memory reactivation during a 2-hour nap did not improve motor retention in 20 Parkinson’s disease patients or 20 healthy older adults, even though the same cues changed sleep physiology by reducing spindle density and increasing slow-wave density.1 Research Highlights First Parkinson’s TMR test: Micca et al. studied 20 Parkinson’s disease patients and 20 …
A 2026 retrospective case series of 22 adults with treatment-resistant depression and comorbid PTSD found that trauma re-experiencing during intranasal esketamine disappeared over later sessions in 72.7% of patients, while 27.3% stopped esketamine because the flashbacks persisted.1 Research Highlights Flashbacks usually faded, but not always: In 16 of 22 patients (72.7%), esketamine-related trauma re-experiencing disappeared …
A 2026 eLife study recorded 3,881 lateral orbitofrontal cortex units in rats and found that prior cocaine use made the OFC over-distinguish task positions that controls treated as functionally equivalent. The headline result was not gross task failure: cocaine-experienced rats still performed the odor task, but their OFC ensembles showed higher S1-vs.-S2 decoding than sucrose …
A 2026 case report linked 1 mg nightly guanfacine modified-release to first-ever cessation of intrusive deliberate self-harm thoughts in a 16-year-old with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) traits, borderline personality disorder (BPD) traits, and post-traumatic stress disorder (PTSD). The same case became more interesting after the patient stopped taking guanfacine and the self-harm …
Parenteral clomipramine has a strong clinical myth around it: bypass the gut, raise parent-drug exposure quickly, and maybe accelerate rescue in severe depression or OCD. A 2026 systematic review found the route advantage was not clearly proven: in depression, 5 RCTs without high risk of bias did not show clear IV or IM superiority over …
A 2026 longitudinal MRI preprint involving 54 people with Friedreich ataxia and 57 controls found 3 biologically interpretable progression subtypes: microstructure-dominant, macrostructure-dominant, and minimal/no progression.1 The clusters make biomarker heterogeneity visible at the research level, while the classifier remains too early to assign individual patients to treatment paths. Research Highlights 3 MRI progression subtypes emerged: …
A 2026 Freedom of Information survey of all 50 English NHS trusts providing inpatient psychiatric care found a basic visibility failure: only 5 trusts could say how many psychiatric inpatients were parents, only 11 could describe routine parental-status data collection, and only 1 held child-visit data.1 Research Highlights Parent counts were mostly unavailable: 5 of …