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Restless Legs in Pregnancy: Stepped-Care Recommendations

Restless legs syndrome (RLS), now also called Willis-Ekbom disease (WED), is a sleep-disrupting neurologic disorder that affects roughly 20–30% of pregnancies in some series and is linked to preeclampsia, increased cesarean delivery, and perinatal depression. A 2026 Nature and Science of Sleep synthesis turned 9 source documents into 27 practice recommendations across 5 domains, ending …

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Parent Youth Quality-of-Life Scale Linked to Suicidality at r = -0.50

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A 2,251-child national parent-report preprint found that the 7-item Parent-report Nationwide Quality of Life Scale had internal reliability of alpha = 0.85 and correlated most strongly with suicidality (r = -0.50), depression (r = -0.47), and internalizing symptoms (r = -0.43).1 Research Highlights Reliability was solid for a brief scale: the 7-item parent P-NQLS showed …

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Trauma Disrupts Parent-Child Fear Extinction in Youth With PTSD Symptoms

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A 97-dyad adolescent fMRI study found that trauma-exposed youth with high posttraumatic stress symptoms did not use parent-observed safety learning in the usual way: their arousal rose to a safety cue during vicarious extinction, F(1,159) = 4.81, p = 0.029, and parent-child physiological synchrony no longer predicted lower skin conductance during early safety learning.1 The …

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OCD Clinical AI Reached AUROC 0.653 but Failed Site Generalization

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A 2026 ENIGMA-OCD preprint tested a transformer model on resting-state fMRI from 1,706 participants and reached AUROC = 0.653 ± 0.039 for OCD classification.1 The more important result was the failure mode: held-out-site performance ranged from AUROC 0.427 to 0.819, which is exactly the gap clinical AI has to close before brain-scan diagnosis is credible. …

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rTMS Plus Risperidone Improved Schizophrenia Cognition

A 2026 randomized study involving 80 people with schizophrenia found that adding high-frequency repetitive transcranial magnetic stimulation to risperidone improved PANSS cognitive-factor scores and aggressive-behavior ratings more than risperidone alone over 4 weeks.1 Research Highlights Design was randomized but short: 80 patients were assigned to risperidone alone or risperidone plus rTMS, 40 per group, with …

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Workplace Mental Health Apps Split Outcomes: Anxiety Down, Wellbeing Up

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A 228-person randomized trial found a split result for workplace mental-health apps: executive-function training reduced anxiety and depressive symptoms at 12-week follow-up, while a self-guided CBT app improved workplace wellbeing without reducing symptoms.1 The mechanism claim was weaker than the outcome claim because measured executive-function change did not explain the improvements. Research Highlights 228 adults …

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