A 2026 medRxiv preprint using parent-cocreated sensory-related outcome measures found that 83% of children and teens improved on at least 1 PROMIS domain during 6 months of bumetanide treatment.1 The result is interesting, but the unmasked single-case design means the strongest claim is about sensitive outcome tracking, not definitive bumetanide efficacy. Research Highlights Most participants …
A 2026 medRxiv preprint involving 44 people with chronic post-stroke aphasia found reduced performance on nonverbal false-belief tasks in 23% of participants on the Reality-Unknown task and 36% on the Reality-Known task, with accuracy tied more clearly to cerebral microbleed burden than to aphasia severity.1 The result reframes social-cognitive testing after stroke as a vascular …
A 2026 juvenile rat study found that inactivating the ventral pallidum or stimulating nucleus accumbens GABA terminals in the ventral pallidum reduced social play behavior in both sexes, pointing to a specific reward-circuit pathway required for normal play expression.1 Research Highlights VP inactivation reduced play: bilateral muscimol infusion into the ventral pallidum reduced juvenile social …
A 2026 review argues that neurovascular-unit dysfunction may precede amyloid-beta generation in Alzheimer’s disease and then synergize with amyloid deposition, tau pathology, inflammation, and neuronal loss.1 The model is vascular biology plus amyloid biology: blood vessels, barrier integrity, and amyloid deposition can amplify each other early enough to affect dementia risk and progression. Research Highlights …
A 2026 fMRI study of 45 adults with strong pro- or anti-refugee stances found that people made more socially mindful choices for ingroup partners than for outgroup or unclassified partners, with mean socially mindful choices of 19.36 for ingroup, 17.18 for outgroup, and 16.31 for unclassified partners.1 Outgroup prosocial choices still occurred, but they recruited …
A 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal channel relevant to Parkinson’s risk biology.1 Acidifying the luminal side from pH 7.4 to 4.7 activated proton conductance, shifted reversal potential, and tied H57 to H+ and K+ flux. Research Highlights Acidification activated TMEM175: lowering luminal-side pH from 7.4 to 4.7 increased inward …
A pilot randomized trial involving 71 refugees with posttraumatic stress disorder found large symptom improvement after narrative exposure therapy-based care, but adding refugee-adapted emotion-regulation training before narrative exposure therapy did not outperform supportive problem-solving before narrative exposure therapy in the full sample.1 Research Highlights 71 refugees were randomized: 35 received STAIR-R plus narrative exposure therapy, …