MentalHealthDaily

Closed-Loop Subgaleal ISP Reduced Epilepsy Seizure Incidence 80%

by GLOOM

Editorial card showing subgaleal electrode strips, closed-loop seizure detection, and focused neurostimulation for therapy-resistant epilepsy.

A 2026 first-in-human medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation shortened stimulated seizures by 52% on average and reduced seizure incidence by 80.9% after 48 hours in 5 high-frequency therapy-resistant epilepsy patients. The signal is promising because it combines responsive seizure detection with electrode strips placed under the scalp rather than electrodes implanted …

Digital Mental Health Visualizations: 6 Tools for Anxiety, Depression

by GLOOM

MHD featured image for digital mental health data visualizations in anxiety and depression care.

A 2026 participatory-design and case-study paper turned smartphone mental-health data into 6 clinician-facing visualizations for an 8-week anxiety/depression digital clinic, using feedback from 15 clinicians and 3 clinical supervisors. The useful claim is workflow-level: charts made passive sensing and symptom ratings discussable inside care, but the paper did not test whether the visualizations improved clinical …

Methamphetamine Treatment Access: 78% Had Never Sought Care

by GLOOM

MHD featured image for methamphetamine treatment access, stigma, and barriers to care in Australia.

A 2026 Australian interview study involving 27 adults with methamphetamine use problems found that 21 participants, or 77.8%, had never previously sought treatment for methamphetamine use. Research Highlights Most had never sought treatment: Peart et al. interviewed 27 adults and found that 77.8% had not previously sought methamphetamine treatment before entering the parent trial.1 3 …

Subcallosal Cingulate DBS for Treatment-Resistant Depression

by GLOOM

A 2026 systematic review of subcallosal cingulate (SCC) functional connectivity found 28 qualifying resting-state fMRI studies in depression: 21 rTMS/iTBS studies, 4 ECT studies, 3 focused-ultrasound studies, and 0 DBS or tDCS studies.1 That number is the useful correction: SCC DBS may still be biologically plausible, but the current fMRI connectivity literature mostly explains noninvasive …

Sleep Memory Cues Do Not Boost Parkinson’s Motor Learning

by GLOOM

Photoreal illustration of an older adult sleeping with overlay of memory and brain oscillation imagery, conveying sleep-based learning intervention.

Auditory targeted memory reactivation during a 2-hour nap did not improve motor retention in 20 Parkinson’s disease patients or 20 healthy older adults, even though the same cues changed sleep physiology by reducing spindle density and increasing slow-wave density.1 Research Highlights First Parkinson’s TMR test: Micca et al. studied 20 Parkinson’s disease patients and 20 …

Gamma Brain Stimulation Helps Schizophrenia More Than Depression

by GLOOM

Photoreal illustration of gamma-frequency brain stimulation showing TMS coil and oscillation waveforms in 30-50 Hz range over a brain.

A 2026 meta-analysis of 56 controlled trials found the clearest gamma-frequency neuromodulation signal in schizophrenia: overall symptoms improved vs. control (g = −0.46), global cognition improved (g = 0.55), and MDD showed a smaller depression effect than the schizophrenia symptom estimate (g = −0.34). Bipolar disorder and autism stayed directional but nonsignificant, and the paper’s …

VNS After Failed Epilepsy Surgery Reduced Seizures 76% at 36 Months

by GLOOM

Photoreal illustration showing an implanted vagus nerve stimulator and brain pathways, representing neuromodulation for drug-resistant epilepsy.

A 2026 CORE-VNS registry analysis found that implanted vagus nerve stimulation still produced large 36-month seizure reductions after failed intracranial epilepsy surgery: median all-seizure reduction was 76.3% with prior surgery vs. 76.6% without prior surgery.1 Research Highlights Prior surgery did not blunt the main VNS signal: CORE-VNS reported 76.3% median all-seizure reduction at 36 months …