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Suicide

ME/CFS Memorial Entries: 505 Death Narratives Show Suicide Risk Gaps

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MHD featured image for ME/CFS memorial entries, systemic neglect, and suicide risk.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystem illness marked by post-exertional malaise, cognitive dysfunction, pain, sleep disruption, and autonomic symptoms; a 2026 PLOS One qualitative analysis of 505 memorial entries found that bereaved accounts repeatedly placed death inside 4 overlapping contexts: systemic neglect, clinical dismissal, social disconnection, and personal functional collapse.1 Research Highlights …

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XGBoost Suicide Risk Model Reached 96% PPV at Top 0.1% Threshold

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MHD featured image for suicide-risk machine learning, precision, cost, and fairness.

A 2026 Scientific Reports study of Maryland suicide-death records found that an XGBoost machine-learning model could reach 96.1% positive predictive value in hospital-discharge data at the top 0.1% risk threshold, but it still detected only 46.7% of suicide deaths in that cohort. Research Highlights Precision improved at the narrowest threshold: XGBoost reached PPV 0.961 in …

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Suicide in Sculpture: Public Art Makes Risk Socially Visible

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MHD featured image for suicide-themed sculpture, public art, psychache, and prevention.

A 2026 qualitative analysis treated suicide-themed sculpture as cultural evidence, showing how public artworks can materialize psychological pain, shame, entrapment, social disconnection, and prevention debates without turning artists or viewers into diagnostic case studies.1 Research Highlights 2026 analysis used cultural methods: the researchers used iconographic, semiotic, and contextual analysis rather than clinical diagnosis or outcome …

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1 mg Guanfacine for Self-Harm Thoughts in ADHD-PTSD-BPD Case

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MHD featured image for 1 mg guanfacine and self-harm thoughts in complex ADHD, PTSD, BPD, and ASD comorbidity.

A 2026 case report linked 1 mg nightly guanfacine modified-release to first-ever cessation of intrusive deliberate self-harm thoughts in a 16-year-old with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) traits, borderline personality disorder (BPD) traits, and post-traumatic stress disorder (PTSD). The same case became more interesting after the patient stopped taking guanfacine and the self-harm …

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Ketamine Addiction After One Therapeutic Dose: How Rare Is It?

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Stylized illustration evoking the tension between ketamine's clinical promise for depression and its abuse liability, framed in muted rose and amber tones for the addiction topic.

Ketamine and its S-enantiomer esketamine (sold as Spravato) are now established treatments for treatment-resistant depression and acute suicidality. The standard safety pitch from sponsors and clinics: at single sub-anesthetic doses, in supervised settings, addiction risk is minimal. A new case report in BJPsych Open documents a patient for whom that pitch failed catastrophically — and …

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