Popular coverage of chronotype neuroimaging usually claims that late chronotypes (evening types, often called “night owls”) show smaller cortical regions and faster brain aging than early chronotypes (morning types). A 2026 multimodal structural MRI analysis from Beheshti and Elkana ran the comparison in 136 healthy young adults using strict whole-brain correction, and the group differences …
Psychiatric brain biomarkers have produced a large research literature but little routine clinical use. A 2026 evidence map found 441 primary studies and 27 systematic reviews of neuroimaging or neurophysiologic biomarkers for mental-health disorders, yet the field still looks too small, cross-sectional, and depression-heavy for ordinary diagnostic or treatment decisions.1 Research Highlights Large map, weak …
A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …
A 2026 multimodal MRI study found that treatment-resistant depression had lower coordination between brain structure and brain activity than non-treatment-resistant depression in frontal, parietal, motor, and temporal regions. Machine-learning models using those structure-function coupling measures classified treatment-resistant vs. non-treatment-resistant depression with AUC values from 0.886 to 0.950 in the primary atlas analysis.1 Research Highlights TRD …
A 2026 hospital MRI study found that the left paracingulate sulcus was present in 31 of 109 catatonia patients (28%) vs. 171 of 323 psychiatric controls without catatonia (53%), a left-hemisphere group effect that survived adjustment for age, sex, scanner, brain volume, benzodiazepines, and antipsychotics.1 Research Highlights Left PCS signal: left paracingulate sulcus (PCS) presence …
Transcranial Magnetic Stimulation (TMS) has emerged as a beacon of hope in the realm of psychiatry, offering a non-invasive alternative for treating psychiatric disorders. The variability in treatment outcomes highlights the necessity for advancements in personalized approaches. A recent paper analyzed the potential of personalized TMS protocols (customized based on individual brain connectivity) may help …
Depression is a complex mental health condition that significantly affects an individual’s emotional and physical well-being. Recent advances in neuroimaging have provided deeper insights into how major depressive disorder (MDD) alters brain structures, particularly the hippocampus and amygdala, and how treatments like ketamine can potentially reverse these changes. A new study using 3T and 7T …