Mental Health DailyResearch. Evidence. Perspective.Published research on major depressive disorder.
In 202 Tokyo outpatients, about 43% of people with major depression and 43% with bipolar disorder reported anxious distress, which was linked to more severe depression in both.
Read articleA 7-trial review favored adding celecoxib to antidepressants for depression, but its benefit was not confirmed after 3 high-risk trials were excluded.
Read articleA 76-person Nature Communications fMRI study found that people with major depressive disorder spent a higher share of time in a model-derived State 3 than healthy controls, 27.63 vs. 25.65, …
Read articleA 40-person pilot trial found depression remission in 69% of adults who did 30 minutes of moderate exercise before individual CBT, compared with 33% of adults who did a calming pre-CBT activ…
Read articleA 2026 Add Health analysis found that combining major-depression and alcohol-use-disorder polygenic scores added 4.88% variance for comorbid MDD-AUD prediction, while same-trait scores added…
Read articleA 2026 systematic review found that microglia-related immune signals do not line up cleanly with psychiatric diagnosis labels: major depression showed frontolimbic TSPO-PET increases, while …
Read articleA 2025 Journal of the American Chemical Society study identified 4 unusual Morganella morganii phospholipids that activated TLR2/TLR1 immune receptors and induced inflammatory cytokines, esp…
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