Mental Health DailyResearch. Evidence. Perspective.Published research on major depressive disorder.
A 2026 biomarker study found kynurenine-pathway activation in inflammatory major depressive disorder (MDD), but not across all depression cases. Compared with non-inflammatory MDD and health…
Read articleWhole-body hyperthermia looks less like generic relaxation and more like a timed biological stressor: in a small depression substudy, a single session was followed by early Hamilton Depressi…
Read articleA 25-person pilot study of young adults found an ATP fatigue pattern that was directionally reversed from the simple “low brain energy” story: the depression group had higher visual-cortex A…
Read articleA 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmac…
Read articleA 2026 meta-analysis of 56 controlled trials found the clearest gamma-frequency neuromodulation signal in schizophrenia: overall symptoms improved vs. control (g = −0.46), global cognition i…
Read articleAn ear-clip that modulates mood by stimulating the vagus nerve has obvious appeal — but the evidence base for non-invasive tVNS in depression has been mixed for a decade. A 2026 cross-over R…
Read articleA 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
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