A 2026 Molecular Psychiatry study found that oral FP802 disrupted the NMDAR/TRPM4 death complex and preserved memory-task performance in 5xFAD Alzheimer’s mice treated for 3 months.1 The finding is mechanistically sharper than a generic anti-amyloid claim: FP802 targeted a glutamate-toxicity complex downstream of amyloid stress. Research Highlights Complex formation was blocked: 5xFAD mice had increased …
Mental-health AI agents are software systems that use artificial intelligence to screen, coach, triage, document, or coordinate care across mental-health workflows. A 2026 systematic review and meta-analysis of systems published from 2023 to 2025 found strong offline diagnostic metrics, but the evidence still leans much more heavily on chatbot demos and benchmark tasks than on …
A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …
In APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven clearance — a plausible mechanism, not a human treatment result yet.1 Research Highlights PTP1B loss improved behavior in APP/PS1 mice. Genetic deletion and DPM-1003 treatment improved novel object recognition and …
Cocaine relapse circuitry looks different when alcohol is part of the history. In a rat model, inhibiting prelimbic cortex neurons projecting to the nucleus accumbens core blocked cue-triggered cocaine seeking after cocaine alone, but failed after sequential cocaine-alcohol polysubstance use.1 Research Highlights PL-NAc inhibition split by drug history: in a 4-group DREADD experiment, inhibiting the …
Psychopathy is not a simple “low empathy equals abnormal brain scan” story. In 804 incarcerated men, psychopathy factors tracked empathic concern, perspective taking, cortical thickness, surface area, and cortical organization—but self-reported empathy scores did not map cleanly onto cortical structure.1 Research Highlights The sample was unusually large for forensic MRI. Radecki et al. analyzed 804 …
A 9-person randomized crossover neuroimaging substudy found that high-polyphenol extra-virgin olive oil increased occipital resting-state functional connectivity compared with regular olive oil, beta = 0.20, 95% CI 0.03 to 0.37, p = 0.016.1 The result is a measurable brain-signal finding, but the clinical claim stays small: connectivity changed, cognition was not the endpoint. Research Highlights …