A 2026 ABCD stop-signal fMRI study found that group-level cognitive-control brain signals often failed to describe within-person brain dynamics: across 16 comparisons, between-person and within-person associations diverged, and several reversed direction.1 The practical warning is narrow but sharp: a brain pattern that separates people in a group may be the wrong map for explaining how …
A 2026 TADPOLE modeling study reported that a sequential neural process with normalizing flows predicted future Alzheimer diagnostic stage with mAUC 0.965 ± 0.006, ahead of the authors’ earlier sequential-neural-process model at 0.937 ± 0.014.1 The result is a strong benchmark signal for uncertainty-aware disease-progression AI, but it is still retrospective modeling evidence rather than …
A 2026 Drosophila Parkinson’s model exposed male and female flies to 500 μM rotenone. By 60 days, male flies had worse survival/climbing than female flies; the paper is a vulnerability screen, not evidence that the same genes are ready human biomarkers.1 Research Highlights 500 μM rotenone split male and female flies: Iyer et al. used …
A 337-person SYNGAP1-DEE registry preprint found caregiver-reported autistic behavior scores linked most strongly to atypical absence seizures (n = 77; FDR-adjusted p = .001), while peak seizure-frequency ratings were not detectably associated with those behavior scores.1 Research Highlights Seizure type carried the signal: atypical absences were associated with higher caregiver-reported autistic behavior scores in 77 …
A 2026 medRxiv genetic analysis linked type 2 diabetes and 2-hour postprandial glucose — the blood-sugar rise after an oral glucose challenge — to higher lacunar stroke risk, with a stronger direct signal for post-meal glucose than for HbA1c after adjustment for brain small-vessel imaging markers.1 Research Highlights Lacunar stroke was the clearest endpoint: genetically …
A 2026 target-trial emulation involving 102,361 U.S. veterans with type 2 diabetes found no increased suicidality risk after starting semaglutide vs. sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors): suicidal ideation HR 0.99 and suicide attempt/death HR 1.05 after overlap weighting.1 That does not prove semaglutide prevents suicide, but it weakens the broad claim that semaglutide initiation itself …
A 91-player adolescent football preprint mapped head-impact-related cortical slowing onto brain receptor and gene-expression maps: concussion-related slowing aligned with norepinephrine transporter density, r = 0.43, and alpha-4 beta-2 nicotinic receptor density, r = 0.50, while aligning inversely with dopamine D2, BDNF, and APOE maps.1 The result is a mechanistic clue about where head-impact physiology may …