A 2026 review in the Japanese Journal of Radiology argued that amyloid PET has moved from an optional Alzheimer’s disease biomarker to a practical eligibility gate for anti-amyloid antibody therapy, while tau PET and FDG-PET answer different questions in the same clinical workflow.1 The key shift is not that every memory complaint needs PET; it …
A 2026 humanized P301S tauopathy mouse study found that syntaxin-6 knockout partly rescued early motor impairment from months 1 to 4, protected gait at 5.5 months, reduced frailty (p = 0.0052), and reduced superficial-cortex neurodegeneration at 3 months (p = 0.0055).1 The finding strengthens syntaxin-6 as a tauopathy modifier, but it is still mouse genetics, …
A Nature Communications study found that old vertebrate brains lost almost 40% of cysteine protease deubiquitylase catalytic activity with age, despite relatively stable protein abundance.1 Antioxidant treatment with NACET restored DUB activity in aging brains, making the finding a reversible enzyme-mechanism result rather than a generic “antioxidants reverse brain aging” claim. Research Highlights DUB activity …
Subthalamic deep brain stimulation (STN-DBS) gives most patients with advanced Parkinson’s disease meaningful motor relief, but a subset develops new or worsened impulse control disorders — pathological gambling, compulsive shopping, hypersexuality, binge eating — while others see preexisting symptoms improve. A 2026 prospective preprint from Loehrer et al. used pre-surgical diffusion MRI to identify microstructural …
A 2026 medRxiv meta-analysis of 27 trials found that transcranial direct current stimulation added to cognitive training improved global cognition immediately after treatment by SMD 0.36 compared with cognitive training alone.1 The signal was small, short-term, and rated very low certainty, so it is not evidence that tDCS is a durable cognitive-rehabilitation shortcut. Research Highlights …
A 2026 PREDIMED-Plus cohort analysis linked higher olive-oil intake with 2-year cognitive preservation in 656 older adults, with each 10 g/day increment associated with higher global cognition change compared with lower intake (beta 0.044 z-score; 95% CI 0.013 to 0.075; p = 0.006).1 The more specific signal favored virgin olive oil and gut-microbiome diversity, while …
A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …