A 2026 review argues that neurovascular-unit dysfunction may precede amyloid-beta generation in Alzheimer’s disease and then synergize with amyloid deposition, tau pathology, inflammation, and neuronal loss.1 The model is vascular biology plus amyloid biology: blood vessels, barrier integrity, and amyloid deposition can amplify each other early enough to affect dementia risk and progression. Research Highlights …
A 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal channel relevant to Parkinson’s risk biology.1 Acidifying the luminal side from pH 7.4 to 4.7 activated proton conductance, shifted reversal potential, and tied H57 to H+ and K+ flux. Research Highlights Acidification activated TMEM175: lowering luminal-side pH from 7.4 to 4.7 increased inward …
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores showed distinct resting facial action-unit patterns: AU10 upper lip raiser, AU23 lip tightener, and AU28 lip suck differed after correction in 45 analyzable participants.1 The result supports facial-expression screening research, but it does not show that a face video can diagnose MCI or …
A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy young adults, healthy older adults, and Parkinson’s disease patients, p = 0.0032, while gamma efficiency-sympathetic coupling differed at p = 0.0003.1 The main claim is that motor, cognitive, and autonomic physiology may be coupled tightly enough to deserve biomarker-level study. Research Highlights Brain-heart …
A 2026 medicinal-chemistry study found that thymol carbamate TC-6 inhibited human butyrylcholinesterase at 3.6 nM, showed more than 2,500-fold selectivity over human acetylcholinesterase, crossed a blood-brain-barrier screening assay, and improved spatial-memory behavior in amyloid-β-injected mice. Research Highlights TC-6 hit BuChE hard: Wu et al. reported human butyrylcholinesterase (BuChE) inhibition at 3.6 nM, compared with 9,320 …
A 2026 Journal of Neuroinflammation study involving 33 people with multiple sclerosis and 10 healthy controls found disease-specific B-cell repertoire signatures even when ordinary B-cell subset counts looked modest, then showed that most disease-modifying therapies shifted repertoire diversity after 6 months. Research Highlights Repertoire sequencing found MS signal: Vasilenko et al. analyzed more than 196,100,000 …
A 259-person multiple system atrophy survey found diagnosed neurogenic orthostatic hypotension in 41.7% of respondents, while another 40.0% had upright symptoms suspicious for nOH without a diagnosis and 21.2% reported never having upright blood pressure measured.1 The operational problem is simple: in MSA, low blood pressure on standing can be disabling, missed, and still undertreated …