Chronic low-grade inflammation rises with age, and a growing body of work asks whether peripheral inflammatory markers in blood track subtle changes in brain white-matter microstructure on MRI. A 2026 preprint from the Healthy Minds for Life cohort by Mishra and colleagues at Johns Hopkins examined 457 dementia-free adults aged 50–79 and found that higher …
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.
Transcranial Direct Current Stimulation (tDCS) has been explored as a potential treatment for major depressive disorder (MDD), particularly for patients who have not responded to traditional treatments like selective serotonin reuptake inhibitors (SSRIs). This non-invasive technique involves applying a weak electrical current to the prefrontal cortex of the brain, aiming to modulate neurocognitive functions. However, …
Traumatic brain injury (TBI) remains one of the most challenging conditions for modern neurology, carrying a wide range of long-term consequences that can significantly impair an individual’s quality of life. In a new study, researchers analyzed the epigenetic landscape post-TBI, revealing significant DNA methylation changes in the hippocampus—a crucial area for memory and learning. The …
Sleep deprivation (SD) is a common issue in today’s fast-paced world, leading to temporary cognitive impairments that can significantly affect daily functioning. However, new research reveals that even a short nap following a period of SD can help reverse these impairments to some extent, shedding light on the brain’s remarkable ability to recover. Highlights: Cognitive …
In the quest for more effective treatments for Alzheimer’s Disease (AD), berberine, a bioactive compound derived from traditional Chinese medicine, has emerged as a promising candidate. Recent preclinical studies have showcased its potential to combat the debilitating effects of AD, with evidence pointing towards its ability to improve cognitive functions, reduce hallmark AD pathologies such …