A 2025 Nature Communications study found that Alzheimer’s-like mice lost locus coeruleus noradrenergic axons in the olfactory bulb early: 14% loss by 2 months, 27% by 3 months, and 33% by 6 months, before broader forebrain axon degeneration appeared.1 Early smell loss may reflect a specific brainstem-to-olfactory circuit injury, while smell testing still needs biomarker …
A 2026 preprint involving 31 children and adolescents treated for medulloblastoma found that silent verb-generation fMRI separated pre- from post-radiotherapy scans with 80.7% leave-one-subject-out accuracy (p = 0.0149).1 The signal points to early cerebellar-cerebral language-network change, not yet to a proven long-term cognitive endpoint. Research Highlights Classifier performance was above chance: A linear support-vector machine …
A 2025 Nature Aging study found that hippocampal ferritin light chain 1 (FTL1) rose with age in mouse neurons, tracked poorer cognition, and became experimentally reversible in old mice. This is an animal-mechanism result, not a human anti-aging treatment.1 Research Highlights FTL1 rose in aged hippocampus: Western blot data showed higher hippocampal FTL1 in aged …
A 2026 automated MRI analysis of 153 adults with first cortical middle cerebral artery stroke found that remote deep gray nuclei changes were already measurable within 21 days, and 2 asymmetry markers independently predicted 3-month disability change: putamen volume Z-score asymmetry (β = −0.24; p = 0.021) and thalamic apparent diffusion coefficient asymmetry (β = …
An iScience EEG study found that approximately 80 minutes of natural smartphone use was interleaved with transient beta bursts, especially over bilateral sensorimotor cortex, and touchscreen intervals became longer when sensorimotor bursts were present.1 Research Highlights Natural smartphone behavior carried beta bursts: participants used smartphones with the right thumb for approximately 80 minutes while EEG …
A 2026 Molecular Psychiatry study found that oral FP802 disrupted the NMDAR/TRPM4 death complex and preserved memory-task performance in 5xFAD Alzheimer’s mice treated for 3 months.1 The finding is mechanistically sharper than a generic anti-amyloid claim: FP802 targeted a glutamate-toxicity complex downstream of amyloid stress. Research Highlights Complex formation was blocked: 5xFAD mice had increased …
In APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven clearance — a plausible mechanism, not a human treatment result yet.1 Research Highlights PTP1B loss improved behavior in APP/PS1 mice. Genetic deletion and DPM-1003 treatment improved novel object recognition and …