A longitudinal MIDUS analysis involving 840 adults found that loneliness scores higher than a person's objective social-isolation score were linked to later cognitive impairment mainly through chronic disease burden, while the allostatic-load pathway was weaker than the chronic-disease pathway and not statistically confirmed for the main cognitive outcomes.1 Research Highlights Loneliness was separated from isolation: …
A 2026 PLOS One machine-learning study reported 95.0% accuracy for a hybrid FT-Transformer plus long short-term memory (LSTM) model predicting student mental-health risk. The technical result is strong inside the dataset, but the clinical claim is still limited because the labels came from repository data rather than prospective clinical diagnosis.1 Research Highlights 95.0% accuracy was …
A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …
A 2026 iScience paper used simultaneous sleep EEG-fMRI from 2 healthy cohorts totaling 24 people to build slow-wave-related BOLD reference maps and propose SloCAD, a framework for measuring how an individual’s slow-wave brain activity deviates from a healthy reference pattern.1 Research Highlights The proof of concept used 24 healthy participants: 2 independent cohorts (N1 = …
The MIND migraine feasibility study showed that remote migraine-cognition monitoring can produce a large daily dataset: 177 baseline participants completed 3,688 smartphone assessments, covering 70.8% of possible study days.1 The finding supports digital migraine endpoint infrastructure while leaving treatment effects and diagnostic thresholds untested. Research Highlights Daily monitoring was feasible: Participants completed 3,688 daily smartphone …
A 2026 medRxiv preprint involving 44 people with chronic post-stroke aphasia found reduced performance on nonverbal false-belief tasks in 23% of participants on the Reality-Unknown task and 36% on the Reality-Known task, with accuracy tied more clearly to cerebral microbleed burden than to aphasia severity.1 The result reframes social-cognitive testing after stroke as a vascular …
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores showed distinct resting facial action-unit patterns: AU10 upper lip raiser, AU23 lip tightener, and AU28 lip suck differed after correction in 45 analyzable participants.1 The result supports facial-expression screening research, but it does not show that a face video can diagnose MCI or …