A 2026 cross-sectional schizophrenia study found no meaningful association between antipsychotic dose and Montreal Cognitive Assessment (MoCA) performance in young, clinically stable outpatients. Cognitive scores related more strongly to symptom burden, illness duration, education, and age at diagnosis than to daily or 1-year cumulative antipsychotic exposure.1 Research Highlights Daily dose was not linked to MoCA: …
A 2026 medRxiv meta-analysis of 27 trials found that transcranial direct current stimulation added to cognitive training improved global cognition immediately after treatment by SMD 0.36 compared with cognitive training alone.1 The signal was small, short-term, and rated very low certainty, so it is not evidence that tDCS is a durable cognitive-rehabilitation shortcut. Research Highlights …
A 2026 PREDIMED-Plus cohort analysis linked higher olive-oil intake with 2-year cognitive preservation in 656 older adults, with each 10 g/day increment associated with higher global cognition change compared with lower intake (beta 0.044 z-score; 95% CI 0.013 to 0.075; p = 0.006).1 The more specific signal favored virgin olive oil and gut-microbiome diversity, while …
A longitudinal MIDUS analysis involving 840 adults found that loneliness scores higher than a person's objective social-isolation score were linked to later cognitive impairment mainly through chronic disease burden, while the allostatic-load pathway was weaker than the chronic-disease pathway and not statistically confirmed for the main cognitive outcomes.1 Research Highlights Loneliness was separated from isolation: …
A 2026 PLOS One machine-learning study reported 95.0% accuracy for a hybrid FT-Transformer plus long short-term memory (LSTM) model predicting student mental-health risk. The technical result is strong inside the dataset, but the clinical claim is still limited because the labels came from repository data rather than prospective clinical diagnosis.1 Research Highlights 95.0% accuracy was …
A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …
A 2026 iScience paper used simultaneous sleep EEG-fMRI from 2 healthy cohorts totaling 24 people to build slow-wave-related BOLD reference maps and propose SloCAD, a framework for measuring how an individual’s slow-wave brain activity deviates from a healthy reference pattern.1 Research Highlights The proof of concept used 24 healthy participants: 2 independent cohorts (N1 = …