A 2026 Saudi tertiary-hospital study estimated that adults treated for fibromyalgia — chronic widespread pain with fatigue, sleep disruption, cognitive symptoms, and overlapping mood or medical problems — generated SAR 9,601.2 (USD 2,560.3) in annual direct medical costs per patient, with specialist visits and diagnostic procedures accounting for 96.3% of recorded spending.1 Research Highlights Annual …
A 2026 iScience study found that 45 days of clomipramine improved spatial, working, and reference memory in female APP/PS1 Alzheimer’s-model mice, apparently by blocking the E3 ubiquitin ligase Itch rather than by clearing amyloid plaques.1 Research Highlights 45-day clomipramine signal: 6-month female APP/PS1 mice received 25 mg/kg clomipramine every other day for 45 days, then …
A 2026 two-experiment study found no visual-working-memory benefit from parietal or occipital transcranial direct current stimulation, while distraction unexpectedly made the cardinal-over-oblique orientation advantage stronger than it was without distraction: the pooled distraction-by-angle interaction had BFinc = 1021.671.1 Research Highlights Distraction strengthened the bias: pooled data from 68 analyzed adults showed a strong distractor-by-angle interaction, …
A 2026 first-in-human medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation shortened stimulated seizures by 52% on average and reduced seizure incidence by 80.9% after 48 hours in 5 high-frequency therapy-resistant epilepsy patients. The signal is promising because it combines responsive seizure detection with electrode strips placed under the scalp rather than electrodes implanted …
Statins do not look like a dementia-prevention drug, but they do not look like a dementia hazard either. In 322,358 Kaiser Permanente Northern California patients followed for an average of 11.8 years, dementia diagnoses rose right after statins were started, then flattened: after the first year, the hazard ratio for Alzheimer’s disease and related dementias …
A 2026 PRISMA systematic review by Cavallo et al. in Cognitive, Affective, & Behavioral Neuroscience aggregates 43 neuroimaging studies of social cognition in adults with stroke or traumatic brain injury and finds the same handful of regions implicated again and again: the insula, cingulate cortex, middle frontal gyrus, and corpus callosum.1 Research Highlights Stroke/TBI social-cognition …
Cognitive impairment in first-episode schizophrenia (FES) is the symptom that does the most work blocking employment, relationships, and independent living — and the symptom current antipsychotics barely move. A 2026 RCT by Hu et al. in Psychological Medicine tested whether 20 sessions of low-frequency rTMS targeting the right orbitofrontal cortex (OFC) could improve cognition where …