Parental Mental Illness and Offspring IQ: Schizophrenia Hits Hardest
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
meta-analysis
Trauma Reminders Increase Drug Cravings — Negative Affect Is the Link
Trauma reminders trigger substance craving — but the path runs through negative emotions, not directly. A 2026 meta-analysis quantifies the link.
How Much Does Loneliness Raise Dementia and Suicide Risk?
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.
When Inflammation Drives Depression — and When It Doesn’t
‘Depression is inflammation’ holds for a subgroup of patients, not for everyone. Community-sample and twin data weaken the broader version of the claim.
ECT: A Modern Reappraisal of Suicide, Dementia, and Mortality
Modern administrative cohorts find no dementia signal for ECT and link it to lower suicide and mortality. The supportive literature carries known biases worth flagging.
CBT-I: First-Line Insomnia Treatment Most People Don’t Get
CBT-I beats sleep medications long-term and self-help versions work too. Sleep hygiene alone isn’t enough — the two are routinely conflated.
Exercise for Depression and Anxiety: 2025 Evidence Synthesis
Exercise reliably reduces depression and anxiety symptoms — but the cardio-vs-resistance gap and antidepressant parity claims are overstated.