When Inflammation Drives Depression — and When It Doesn’t
‘Depression is inflammation’ holds for a subgroup of patients, not for everyone. Community-sample and twin data weaken the broader version of the claim.
meta-analysis
ECT: A Modern Reappraisal of Suicide, Dementia, and Mortality
Modern administrative cohorts find no dementia signal for ECT and link it to lower suicide and mortality. The supportive literature carries known biases worth flagging.
CBT-I: First-Line Insomnia Treatment Most People Don’t Get
CBT-I beats sleep medications long-term and self-help versions work too. Sleep hygiene alone isn’t enough — the two are routinely conflated.
Exercise for Depression and Anxiety: 2025 Evidence Synthesis
Exercise reliably reduces depression and anxiety symptoms — but the cardio-vs-resistance gap and antidepressant parity claims are overstated.
tDCS for Fibromyalgia: Efficacy of Transcranial Direct Current Stimulation (2024 Review)
A recent systematic review and meta-analysis aimed to update the understanding of the efficacy and safety of transcranial direct current stimulation (tDCS) for treating fibromyalgia (FM), focusing on its effects on analgesia, antidepressant outcomes, and the reduction of FM’s impact. Highlights: Efficacy of tDCS: The analysis revealed that tDCS is effective in reducing pain intensity, …
Psilocybin for Depression: Optimal Dosages for Antidepressant Effects (2023 Review)
Recent research has provided compelling evidence on the therapeutic potential of psilocybin, a naturally occurring psychedelic, in treating depression. A systematic review and dose-response meta-analysis shed light on the optimal dosage of psilocybin for depression, revealing variations in effectiveness based on patient subgroups and associated risks. Highlights: Psilocybin showed significant antidepressant effects, with optimal dosages …
Non-Directive Supportive Therapy (NDST) for Major Depression: Is It Effective? (2024 Review)
Depression, a common yet complex mental health disorder, has various treatment options, including psychotherapies like Non-Directive Supportive Therapy (NDST). A recent meta-analysis sheds light on the effectiveness of NDST in treating depression, comparing it with control conditions and other therapies. Highlights: NDST has been identified as a moderately effective treatment for depression compared to control …