Lithium prescribing during pregnancy sits in a knot of competing risks. The teratogenicity data have been recalibrated dramatically since the 1970s, while the postpartum-relapse data have moved in the opposite direction. Most popular framing still treats lithium as a uniquely dangerous fetal exposure to be avoided when possible. The new Chauhan UK cohort shows what …
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
In the intricate world of mental health, the rhythms of our body’s natural processes play a pivotal role, particularly the circadian rhythm of melatonin, a hormone primarily produced by the pineal gland. Recent research suggests that variations in melatonin’s circadian rhythm might not only distinguish between depression and bipolar disorder but also correlate with the …
Bipolar disorder (BD), a complex and multifaceted mental illness, manifests through various mood states including depression, mania/hypomania, and euthymia. Recent advances in neuroimaging, particularly resting-state functional magnetic resonance imaging (fMRI), have shed light on the intricate dynamics of brain activity underlying these mood states. A new study employing dynamic fractional amplitude of low-frequency fluctuations (dfALFF) …
The complex interplay between reproductive behaviors and psychiatric disorders is an area of interest within the scientific community, revealing how our genetic makeup may influence both our reproductive milestones and mental health. A recent study sheds light on this relationship, focusing on the causal pathways linking reproductive behaviors, such as the age at first sexual …
Bipolar disorder (BD) remains a complex psychiatric condition with limited therapeutic options, posing a significant challenge in drug discovery. The latest research leverages network-based drug repurposing, employing advanced computational techniques to identify novel treatment strategies for bipolar disorder. Highlights: Network-based drug repurposing employs gene regulatory networks to identify potential new uses for existing drugs in …
Bipolar Disorder (BD), a complex psychiatric condition, is under constant study to better understand its pathophysiology and improve diagnostic and treatment strategies. Recent research has focused on the role of serum neurofilament light (sNfL), a marker for neuro-axonal injury, in BD. Highlights: Individuals with BD for more than three years exhibit higher sNfL levels compared …