Mental Health DailyResearch. Evidence. Perspective.Published research on bipolar disorder.
A 124-person study of euthymic bipolar disorder found that patients with early systematic antidepressant treatment history had higher negative affect, attentional impulsivity, non-planning i…
Read articleA 2026 systematic review found that microglia-related immune signals do not line up cleanly with psychiatric diagnosis labels: major depression showed frontolimbic TSPO-PET increases, while …
Read articleA 244-person functional MRI study found no significant evidence that ventral striatum activation during reward anticipation works as an endophenotype — a measurable trait used to connect inh…
Read articlePsychiatric brain biomarkers have produced a large research literature but little routine clinical use. A 2026 evidence map found 441 primary studies and 27 systematic reviews of neuroimagin…
Read articleA 2026 resting-state fMRI study of 800 adults found intra-thalamic hypoconnectivity across schizophrenia, bipolar disorder, and major depression, but schizophrenia showed far broader subcort…
Read articleA 60-patient randomized trial of lithium loading for acute bipolar I mania reported faster serum lithium attainment than standard titration and a larger 14-day Young Mania Rating Scale (YMRS…
Read articleWhether alcohol, cocaine, nicotine, and cannabis damage the same brain regions or different brain regions has been hard to settle in the addiction-imaging literature. A 2026 ENIGMA Addiction…
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