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Schizophrenia MRI Subtypes Split 3,958 Patients Into 2 Patterns

MHD featured image for schizophrenia MRI cortical-gradient subtypes.

A 2026 ENIGMA structural MRI preprint involving 3,958 people diagnosed with schizophrenia and 5,489 controls found 2 cortical-alteration subtypes rather than 1 uniform brain pattern.1 The result maps heterogeneity: anterior-cingulate and temporoparietal network patterns may separate patients, but the result is not a diagnostic MRI test. Research Highlights Large MRI base: The analysis included 3,958 …

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Catatonia Brain Circuits: Limbic System Review

MHD featured image for catatonia, limbic-system brain circuits, and psychomotor shutdown.

A 2026 systematic review argues that catatonia should be read as a limbic-cortical circuit syndrome, with motor shutdown tied to brain systems for threat, salience, motivation, and emotional regulation. Research Highlights 20 studies met criteria: the 2026 review screened 1,792 records, assessed 54 full texts, and included 20 articles: 13 observational studies and 7 case …

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Anterior Cingulate Sulcus Asymmetry Linked to Lower Delay Discounting

MHD featured image for anterior cingulate sulcus asymmetry and delay discounting.

A 2026 Human Connectome Project MRI study linked asymmetric anterior cingulate cortex sulcal pattern to lower delay discounting in 390 healthy young adults: asymmetric ACC morphology predicted a higher delay-discounting area under the curve, meaning delayed rewards lost less value.1 The finding is not a diagnostic scan for impulsivity, but it puts an early-formed cortical-folding …

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Late Chronotype MRI Signal Vanishes After Strict Correction

Stylized illustration of an early-morning sky and a late-night sky meeting over a brain in profile, representing the structural neuroimaging question about chronotype in healthy young adults.

Popular coverage of chronotype neuroimaging usually claims that late chronotypes (evening types, often called “night owls”) show smaller cortical regions and faster brain aging than early chronotypes (morning types). A 2026 multimodal structural MRI analysis from Beheshti and Elkana ran the comparison in 136 healthy young adults using strict whole-brain correction, and the group differences …

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Catatonia Linked to Lower Left Paracingulate Sulcus Rate (28% vs 53%)

Photoreal illustration of a brain with the anterior cingulate cortex highlighted, representing transdiagnostic structural markers of catatonia.

A 2026 hospital MRI study found that the left paracingulate sulcus was present in 31 of 109 catatonia patients (28%) vs. 171 of 323 psychiatric controls without catatonia (53%), a left-hemisphere group effect that survived adjustment for age, sex, scanner, brain volume, benzodiazepines, and antipsychotics.1 Research Highlights Left PCS signal: left paracingulate sulcus (PCS) presence …

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