Mental-health AI agents are software systems that use artificial intelligence to screen, coach, triage, document, or coordinate care across mental-health workflows. A 2026 systematic review and meta-analysis of systems published from 2023 to 2025 found strong offline diagnostic metrics, but the evidence still leans much more heavily on chatbot demos and benchmark tasks than on …
A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …
Psychopathy is not a simple “low empathy equals abnormal brain scan” story. In 804 incarcerated men, psychopathy factors tracked empathic concern, perspective taking, cortical thickness, surface area, and cortical organization—but self-reported empathy scores did not map cleanly onto cortical structure.1 Research Highlights The sample was unusually large for forensic MRI. Radecki et al. analyzed 804 …
A 2026 scoping review screened 956 systematic reviews/guidelines and 604 original studies on cancer-survivor neuropathic pain, but only 11 pharmacological, 2 psychological, and 3 exercise studies were eligible.1 The practical signal is narrow: duloxetine and some exercise programs have the clearest support, while psychological and interdisciplinary evidence is still too thin for confident treatment ranking. …
A matched case-control study of 50 children with autism spectrum disorder and 50 controls found that newborn amino acid metabolism overlapped with both later autism diagnosis and prenatal air-pollution exposure.1 The central pathway, aspartate and asparagine metabolism, was associated with autism (p = 0.01), pregnancy PM2.5 (p < 0.001), first-trimester PM2.5 (p < 0.001), and …
Sexual fantasies are not distributed randomly, but the pattern is subtler than popular personality stereotypes imply. In 5,225 adults, conscientiousness and agreeableness tracked lower fantasy frequency, while negative emotionality—especially the depression facet—tracked higher fantasy frequency across multiple fantasy domains.1 Research Highlights 5,225-person sample: Cannoot et al. analyzed adults with mean age 58.30 years; 56.5% were …
A 2026 preprint following 964 adults who used a Chicago mobile medical unit for opioid use disorder care found 5 follow-up patterns over 12 months: 56% made 1 visit, while the remaining patients showed slow decline, fast decline, infrequent use, or continued use.1 Research Highlights The cohort was large for mobile OUD care: 3,528 OUD-related …