In a 2,411-person multinational twin-consortium study, depressive symptoms increased significantly as death approached. The strongest design check compared twins directly: twins who died had larger terminal symptom increases than co-twins who survived at least 4 more years. Research Highlights Terminal mood change was visible: Petkus et al. found accelerated depressive-symptom increases roughly 4.3 years before …
A 2026 structural MRI study found that cerebellar gray-matter patterns helped distinguish first-episode bipolar depression from unipolar depression: a model using significant cerebellar lobules reached 76.3% accuracy and AUC 0.779.1 The result is best read as proof-of-concept neuroimaging evidence, not as a scan-based bipolar diagnostic test. Research Highlights Classifier performance was moderate: cerebellar lobules with …
A 2026 medRxiv preprint using parent-cocreated sensory-related outcome measures found that 83% of children and teens improved on at least 1 PROMIS domain during 6 months of bumetanide treatment.1 The result is interesting, but the unmasked single-case design means the strongest claim is about sensitive outcome tracking, not definitive bumetanide efficacy. Research Highlights Most participants …
A 2026 medRxiv preprint built a reusable NeuroMark SPECT template from 2 large independent component analysis rounds, then applied it to 137 schizophrenia patients and 76 controls; after false-discovery-rate correction, 23 of 68 perfusion components differed between groups.1 Those data support infrastructure for comparing SPECT perfusion networks across datasets, with standalone schizophrenia diagnosis left outside …
A 430-caregiver study in Kathmandu found caregiving burden in 65.3% of family caregivers of older adults with disability, with adjusted predictors clustering around low economic status, 8 or more daily care hours, and severe impairment in activities of daily living.1 Research Highlights Burden was the majority experience: 65.3% of 430 family caregivers reported caregiving burden …
Major upper-extremity amputation was linked to substantially higher odds of new mental-health diagnosis, antidepressant initiation, and psychotherapy claims than minor upper-extremity amputation in a matched national database study. The clearest clinical implication is early mental-health screening after major limb loss, not waiting for distress to surface months later.1 Research Highlights 2,452 matched patients were analyzed: …
A 2026 study involving 32 adult mangrove rivulus fish pairs found that 3,000 µg/L waterborne psilocybin reduced movement and aggressive swimming bursts, but the result belongs in animal behavioral pharmacology, not in human aggression treatment claims.1 Research Highlights Fish movement decreased: psilocybin produced a treatment-by-time interaction for time spent moving (p = 0.006), with a …