Psilocybin for Depression, MDMA for PTSD: What Phase 3 Trials Show
Media coverage of psychedelics outpaces the trial evidence. MDMA-PTSD signals are large; psilocybin-depression effects shrink against active comparators.
Parental Mental Illness and Offspring IQ: Schizophrenia Hits Hardest
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
CBD Has Strong Evidence for Epilepsy — Weak for Other Medical Conditions
CBD has solid evidence for rare pediatric epilepsies, preliminary signal in anxiety and psychosis, and insufficient evidence for most conditions it’s marketed for.
Trauma Reminders Increase Drug Cravings — Negative Affect Is the Link
Trauma reminders trigger substance craving — but the path runs through negative emotions, not directly. A 2026 meta-analysis quantifies the link.
Global Addiction Rates Fell 17%; U.S. Rates Increased 24%
Global age-standardized substance-use-disorder rates fell 16.9% from 1990–2021. High-income North America rose 24%—the divergence US coverage misses.
AVATAR Therapy vs CBT for Auditory Hallucinations
AVATAR therapy ties CBT at end of treatment, edges ahead at 3-month follow-up, and uses half the sessions. The ‘better than CBT’ framing outpaces the formal statistics.
How Much Does Loneliness Raise Dementia and Suicide Risk?
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.