A 2025 Journal of the American Chemical Society study identified 4 unusual Morganella morganii phospholipids that activated TLR2/TLR1 immune receptors and induced inflammatory cytokines, especially IL-6.1 The finding does not prove that one gut bacterium causes depression, but it gives the microbiome-depression field something it often lacks: a named molecule and a receptor pathway. Research …
A 2026 medRxiv preprint built a reusable NeuroMark SPECT template from 2 large independent component analysis rounds, then applied it to 137 schizophrenia patients and 76 controls; after false-discovery-rate correction, 23 of 68 perfusion components differed between groups.1 Those data support infrastructure for comparing SPECT perfusion networks across datasets, with standalone schizophrenia diagnosis left outside …
A 2026 Nature Neuroscience study found that awake mouse brain motion was driven mainly by locomotion-linked abdominal muscle activity, not by respiration or cardiac rhythm; the researchers mapped displacement vectors at 134 cortical sites in 24 mice and modeled how that motion could push fluid out of brain tissue.1 The result sharpens the body-brain mechanics …
A 259-person multiple system atrophy survey found diagnosed neurogenic orthostatic hypotension in 41.7% of respondents, while another 40.0% had upright symptoms suspicious for nOH without a diagnosis and 21.2% reported never having upright blood pressure measured.1 The operational problem is simple: in MSA, low blood pressure on standing can be disabling, missed, and still undertreated …
A 2026 ADNI/A4 validation study found that Alzheimer’s plasma-biomarker machine-learning models still ranked amyloid PET status well across cohorts, but the practical rule-out number moved hard: negative predictive value fell from 0.831 inside ADNI to 0.644 when the ADNI-trained model was applied to A4.1 Research Highlights 1,707-person ADNI/A4 test: researchers trained amyloid PET prediction models …
A 2026 CNS Drugs review argues that seletracetam, an abandoned second-generation racetam antiseizure drug, may be unusually well suited for seizure rescue: early oral studies involved 171 participants, photosensitivity responses occurred in 32 of 36 exposures, and one intranasal named-patient use reduced reading-induced spike rate from 3.1/min to 1.6/min without sedation. Research Highlights Rescue-therapy rationale: …
Lecanemab blood biomarkers may rebound much faster than amyloid PET after treatment stops: a 2026 PK/PD model estimated that half of the Aβ42/40 treatment effect is lost within 0.5 years, compared with 12.1 years for amyloid PET signal.1 Research Highlights 0.5-year rebound for Aβ42/40: Bhagunde et al. estimated that half of the Aβ42/40 treatment effect …