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Semaglutide Reduced Cocaine Choice in Rat Study

Semaglutide is not close to being an approved cocaine-use-disorder medication, but a 2026 rat study gives the idea a more demanding preclinical test than ordinary self-administration experiments. After 5 days of treatment, rats shifted away from cocaine choice without losing total operant responding, which separates the result from a broad appetite-suppression artifact. Research Highlights Semaglutide …

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GLP-1 Weight-Loss Drugs Triggered Effort-Based Stigma in 4 Studies

MHD featured image for GLP-1 weight-loss medication stigma and effort moralization.

A 2026 Scientific Reports paper involving 1,205 participants found that people using GLP-1-style weight-loss medication were judged as less effortful, less moral, less competent, less warm, less deserving, and less attractive as cooperation partners after the same 20 kg weight loss described for a diet-and-exercise-only comparator. Research Highlights Same weight loss, harsher judgment: Tissot et …

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Semaglutide & Empagliflozin May Treat Obesity-Related Cognitive Impairment (Mouse Study)

Obesity now affects over 650 million adults globally and is a major risk factor for various chronic diseases including cognitive decline and impairment. Recent evidence shows a link between obesity, reduced brain volume and neuronal loss, increased dementia risk, and impaired learning, memory and cognition. Preliminary evidence suggests that weight loss drugs like semaglutide may …

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