Mental Health DailyResearch. Evidence. Perspective.Published research on schizophrenia.
Schizophrenia’s genetic architecture sits awkwardly between neurons and the immune system. A 2026 CRISPR screen of 30 schizophrenia-associated genes in human microglia-like cells found that …
Read articleA 12-week text-message intervention for people with schizophrenia spectrum disorders improved diabetes self-management confidence and patient activation, but it did not yet move weight, HbA1…
Read articleClozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years…
Read articleA 2026 resting-state fMRI study of 800 adults found intra-thalamic hypoconnectivity across schizophrenia, bipolar disorder, and major depression, but schizophrenia showed far broader subcort…
Read articleA 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% …
Read articleCognitive impairment in first-episode schizophrenia (FES) is the symptom that does the most work blocking employment, relationships, and independent living — and the symptom current antipsyc…
Read articleMukai et al.’s 499-person Phase 2b schizophrenia trial tested whether higher, sustained PDE10A inhibition could turn MK-8189 into a non-D2 antipsychotic; it did not. At week 6, MK-8189 misse…
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