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People With Lived Experience Want a Real Say in Schizophrenia Research

MHD card showing a round table with a researcher's clipboard and a peer worker's open notebook connected by a thread of orange light, illustrating a German interview study in which peer support workers and people with schizophrenia asked for a real role in mental health research.

Peer support workers and people diagnosed with schizophrenia want a real say in how mental health research is chosen and run, according to a 2026 German interview study. They valued medication and brain research, but no more than research on therapy, relationships and everyday care.1 Research Highlights 26 interviews, 21 voices on research: researchers interviewed …

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New Schizophrenia Family Resource Questionnaire Passed Early Tests in Beijing

MHD card showing a small house at dusk with a lit window where a caregiver reaches toward a seated relative, surrounded by glowing linked icons for money, time, emotional support, medical care and community, illustrating a questionnaire on family resources for schizophrenia caregivers.

A 37-question survey that maps what a family caring for someone with schizophrenia has to work with, from money and emotional support to community services, held together well in its first full test with 304 caregivers in Beijing.1 Research Highlights What was tested: the M-FRAT, a caregiver-rated questionnaire on family resources for schizophrenia, given to …

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Quetiapine Linked to Better Working Memory Scores in Schizophrenia

MHD card with an amber myelinated nerve fiber, quetiapine tablets, and a digits-backward memory sequence: quetiapine users with schizophrenia scored higher on hard working-memory tests, but myelin genes did not explain it.

A 2026 German-Austrian cohort analysis found that people with schizophrenia who were taking quetiapine scored modestly higher on demanding working-memory tests than sex- and age-matched patients who were not, with the largest gap at doses of 300 mg a day or less.1 Because patients were not randomized to quetiapine, this is an association; the advantage …

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Top-Ranked Treatments for Schizophrenia Aggression: Clozapine, Paliperidone and Olanzapine

MHD card with an amber network of antipsychotic drug nodes linked to a placebo node over a dark background, with a calming waveform: clozapine, paliperidone, and olanzapine reduced aggression in schizophrenia most, but confidence was low.

A 2026 analysis of 41 randomized studies involving 21,025 adults with schizophrenia found the largest estimated reductions in hostility and aggression for clozapine (standardized mean difference, or SMD, of −0.75), paliperidone (−0.62), and olanzapine (−0.60) vs. placebo.1 Confidence in every comparison was low or very low, the top 3 were not statistically separable, and most …

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Lithium vs. Valproate in Residual Schizophrenia: Case Safety Signal

MHD featured image for lithium and valproate augmentation safety in schizophrenia.

A 2026 case report described valproate 800 mg/day improving agitation in residual-phase treatment-resistant schizophrenia but being followed by hypoglycemia and pancytopenia; after discontinuation, lithium 600 mg/day at 0.8 mEq/L was associated with BPRS improvement from 80 to 64.1 The calibrated read is mixed: valproate looked behaviorally useful in 1 patient, but the safety signal was …

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rTMS Plus Risperidone Improved Schizophrenia Cognition

A 2026 randomized study involving 80 people with schizophrenia found that adding high-frequency repetitive transcranial magnetic stimulation to risperidone improved PANSS cognitive-factor scores and aggressive-behavior ratings more than risperidone alone over 4 weeks.1 Research Highlights Design was randomized but short: 80 patients were assigned to risperidone alone or risperidone plus rTMS, 40 per group, with …

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