Mental Health DailyResearch. Evidence. Perspective.Published research on ketamine.
A 2026 review found dexmedetomidine, ketamine, propofol, nerve blocks and acupuncture unproven for chronic insomnia. Their best trials were around surgery; CBT-I remains first-line.
Read articleIn a 2026 mouse study, a single 10 mg/kg dose of ketamine reduced swim immobility in stressed mice with the circuit intact (7 mice, P = 0.0093) but did nothing when the thalamic nucleus reun…
Read articleA 99-patient randomized trial found that adding esketamine to sufentanil patient-controlled analgesia lowered postoperative depression and anxiety scores at 24 and 72 hours after colorectal …
Read articleA 2026 national survey of Dutch emergency physicians found wide variation in first-line medication choices for extreme agitation: without intravenous access, 34.7% preferred midazolam, 23.1%…
Read articleAdding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participan…
Read articleA 2026 retrospective case series of 22 adults with treatment-resistant depression and comorbid PTSD found that trauma re-experiencing during intranasal esketamine disappeared over later sess…
Read articlePTSD and major depressive disorder co-occur in roughly half of patients with either diagnosis, and the comorbid presentation is more severe than either alone. The mechanistic question has be…
Read article
