MentalHealthDaily

Esketamine Nasal Spray Effective Last Resort for Treatment-Resistant Depression (TRD)? (2023 Study)

by GLOOM

Treatment-resistant depression (TRD) represents a significant challenge in mental health care, often leaving patients and clinicians in a difficult position after traditional treatments fail. Recent studies, including a prospective, observational study at a leading medical center, have brought new hope in the form of esketamine, a novel antidepressant. Highlights: Esketamine’s Mechanism: Esketamine, the S-enantiomer of …

Lateral Habenula & Depression: The Anti-Reward Center (Mechanisms & Antidepressant Treatments)

by GLOOM

Depression is a complex and multifaceted disorder affecting millions worldwide. Emerging evidence suggests the lateral habenula, a small brain region, plays a crucial role in depression’s development and persistence. By influencing neurotransmitter systems and interacting with stress pathways, the lateral habenula’s dysfunction may lead to the classic symptoms of depression. Highlights: The lateral habenula is …

Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

by GLOOM

Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …

How Long Does Ketamine Stay In Your System?

by GLOOM

Ketamine is a drug initially synthesized in the 1960s to be used as an anesthetic. It was approved by the FDA in 1970 and was utilized medically as anesthesia for soldiers during the Vietnam war. At the time, ketamine was considered a superior option to PCP (phencyclidine) due to its short duration of effect and …

Drug-Induced Psychosis: List Of Causative Agents

by GLOOM

Psychosis is a condition that is commonly associated with the mental illness schizophrenia. It is defined as a detachment from reality and hallmark symptoms include delusions (beliefs that aren’t based in reality) and hallucinations (seeing, hearing, or feeling stimuli that aren’t real). Those with psychosis are usually admitted to a psychiatric ward and/or hospital and …

Ketamine For Bipolar Disorder: Treats Anhedonia Prior To Depression

by GLOOM

For years, researchers have been investigating illicit drugs to determine whether they could be used under supervision to treat mental illnesses like depression and bipolar disorder. Although many of these substances have shown promise, in many cases the side effects and addiction potential outweigh any therapeutic benefits. Other times, many drugs may be temporarily helpful …

Ketamine Nasal Spray For Fast-Acting Depression Relief

by GLOOM

Ketamine is a drug that is used to induce sedation in humans in a controlled environment. It is also used recreationally and is referred to as “Special K.” Ketamine is an NMDA antagonist that functions as a sedative, analgesic, and has therapeutic properties when used with an anesthetic. In regards to recreational usage, Ketamine has …