Mukai et al.’s 499-person Phase 2b schizophrenia trial tested whether higher, sustained PDE10A inhibition could turn MK-8189 into a non-D2 antipsychotic; it did not. At week 6, MK-8189 missed the PANSS total endpoint at 16 mg (−2.8 points vs. placebo; 95% CI −8.3 to 2.6; P = 0.241) and 24 mg (−0.7 points; 95% CI …
A 2026 task-based fMRI study of 91 young adults separated misophonia from hyperacusis inside the same “sound sensitivity” experiment: misophonia-containing groups showed visual association cortex and ACC-visual network changes during unpleasant sounds, while key hyperacusis contrasts showed weaker salience-control connectivity than misophonia.1 The scan data support separating trigger-specific sound aversion from loudness-driven sound intolerance, while …
A 2026 Nature Communications study found that Mecp2 overexpression deregulated approximately 5,000 genes in mouse neural progenitor cells but only approximately 500 mostly small-change genes in mature neurons, with the same progenitor-vs-neuron split reproduced in human iPSC-derived cells.1 For Rett syndrome gene therapy, that is the useful calibration: extra MeCP2 is most dangerous when it …
A 2026 medRxiv preprint did not find one simple autism excitation-inhibition signature. Bertelsen et al. found 2 EEG-derived E:I neurosubtypes in 286 autistic males: a 47% inhibition-dominant subtype with higher Hurst exponent and lower gamma, and a 53% excitation-dominant subtype with the opposite pattern.1 Research Highlights Two subtypes, opposite directions: in 286 autistic males ages …
A 2026 diagnostic-accuracy preprint found that resting-state EEG network features separated non-lesional epilepsy from functional/dissociative seizures (FDS) at 67.5% balanced accuracy, but the signal was not symmetrical: sensitivity was 81.8% for epilepsy and only 53.3% for FDS.1 In plain clinical terms, the model looked more useful as an epilepsy-supporting marker than as a positive test …
A 2026 ALSPAC analysis tested a narrow claim behind routine genetic screening for childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD): whether rare copy number variants (CNVs; deleted or duplicated DNA segments) make young-adult outcomes worse than ADHD/ASD status alone would predict. In 8,414 people with usable CNV data, ADHD and ASD predicted worse …
A 2026 analysis of 174 people with non-affective first-episode psychosis found that cognitive reserve was tied to 3 signals available near illness onset: age at onset, family history of psychosis, and polygenic liability for educational attainment. Adding the education polygenic score raised the model’s adjusted R² from 13.5% to 17.7%, a real but modest gain …