A 97-dyad adolescent fMRI study found that trauma-exposed youth with high posttraumatic stress symptoms did not use parent-observed safety learning in the usual way: their arousal rose to a safety cue during vicarious extinction, F(1,159) = 4.81, p = 0.029, and parent-child physiological synchrony no longer predicted lower skin conductance during early safety learning.1 The …
A 2026 ENIGMA-OCD preprint tested a transformer model on resting-state fMRI from 1,706 participants and reached AUROC = 0.653 ± 0.039 for OCD classification.1 The more important result was the failure mode: held-out-site performance ranged from AUROC 0.427 to 0.819, which is exactly the gap clinical AI has to close before brain-scan diagnosis is credible. …
A 2026 randomized study involving 80 people with schizophrenia found that adding high-frequency repetitive transcranial magnetic stimulation to risperidone improved PANSS cognitive-factor scores and aggressive-behavior ratings more than risperidone alone over 4 weeks.1 Research Highlights Design was randomized but short: 80 patients were assigned to risperidone alone or risperidone plus rTMS, 40 per group, with …
A 228-person randomized trial found a split result for workplace mental-health apps: executive-function training reduced anxiety and depressive symptoms at 12-week follow-up, while a self-guided CBT app improved workplace wellbeing without reducing symptoms.1 The mechanism claim was weaker than the outcome claim because measured executive-function change did not explain the improvements. Research Highlights 228 adults …
A 2025 iScience study found that nighttime caffeine increased motor impulsivity in Drosophila, with dose-dependent loss-of-inhibition events across n = 30-32 flies per behavioral condition and stronger effects in female flies than male flies.1 The result does not prove that an evening coffee makes humans reckless, but it sharpens a neglected point: caffeine’s alertness benefit …
A 40-person pilot trial found depression remission in 69% of adults who did 30 minutes of moderate exercise before individual CBT, compared with 33% of adults who did a calming pre-CBT activity.1 Compared with a broad “exercise boosts therapy” claim, acute exercise is a plausible priming step; the alliance and activation mechanisms still need a …
A 2026 qualitative study of a 10-week Danish Arts on Prescription program found that young adults aged 18 to 30 often described more stable daily routine, confidence, and belonging, but some activities also caused stress, fatigue, or discomfort.1 The useful interpretation is structured creative groups may help some disconnected young adults rebuild daily life when …