A 40-person pilot trial found depression remission in 69% of adults who did 30 minutes of moderate exercise before individual CBT, compared with 33% of adults who did a calming pre-CBT activity.1 Compared with a broad “exercise boosts therapy” claim, acute exercise is a plausible priming step; the alliance and activation mechanisms still need a …
A 2026 qualitative study of a 10-week Danish Arts on Prescription program found that young adults aged 18 to 30 often described more stable daily routine, confidence, and belonging, but some activities also caused stress, fatigue, or discomfort.1 The useful interpretation is structured creative groups may help some disconnected young adults rebuild daily life when …
A 2026 neuroscience review argues that chemotherapy-induced peripheral neurotoxicity should not be treated as a purely peripheral nerve problem: CIPN affects 70-90% of patients during chemotherapy, persists chronically in 20-30% of survivors, and may interact with central sensitization, pain networks, mood, sleep, and chemobrain.1 The strongest claim is mechanistic connection, not proof that neuropathy alone …
A 2026 multicenter Italian cohort followed 216 early Parkinson’s disease patients for 24 months after levodopa initiation and found sex/gender differences in non-motor symptom burden.1 Women had higher anxiety, pain, mobility, and emotional-well-being burden, while men had higher hypersexuality. Research Highlights Longitudinal sample: The study followed 216 early levodopa-naive Parkinson patients, including 139 men and …
A 99-patient randomized trial found that adding esketamine to sufentanil patient-controlled analgesia lowered postoperative depression and anxiety scores at 24 and 72 hours after colorectal cancer surgery, while resting and activity pain scores did not differ by group.1 That pattern makes the result more interesting than simple pain relief: the mood signal was partly independent …
A 2026 Add Health analysis found that combining major-depression and alcohol-use-disorder polygenic scores added 4.88% variance for comorbid MDD-AUD prediction, while same-trait scores added only 0.65% for MDD and 1.52% for AUD alone.1 The genetic signal is strongest where the clinical problem is hardest: depression plus alcohol-use disorder, not either diagnosis in isolation. Research Highlights …
A 2025 Nature Communications study found that Alzheimer’s-like mice lost locus coeruleus noradrenergic axons in the olfactory bulb early: 14% loss by 2 months, 27% by 3 months, and 33% by 6 months, before broader forebrain axon degeneration appeared.1 Early smell loss may reflect a specific brainstem-to-olfactory circuit injury, while smell testing still needs biomarker …