MentalHealthDaily

Schizophrenia vs. Immune System Activation: Cellular Signatures & Genetic Analysis (2023 Study)

by GLOOM

Schizophrenia (SCZ) is a complex psychiatric disorder that affects millions worldwide, with symptoms ranging from hallucinations to disorganized thinking. Research into the causative factors of SCZ has expanded into the realm of immunology, examining how immune system interactions with the brain might influence the development and progression of the disorder. A recent comprehensive study using …

Gene Editing with CRISPR/Cas9 to Treat Corticosteroid-Induced Neuropsychiatric Disorders (2023 Review)

by GLOOM

The widespread use of corticosteroids (CCSs) across the globe for treating inflammatory conditions has led to an increased incidence of corticosteroid-induced neuropsychiatric disorders (NPDs), raising significant public health concerns. These disorders range from depression and anxiety to severe cognitive changes, challenging the medical community to find effective treatments. The exploration of genetic and epigenetic factors …

PGAM5 Genetics & Depression via ATP Levels in the Prefrontal Cortex (2023 Mouse Study)

by GLOOM

Major depressive disorder (MDD) is a complex and prevalent psychiatric condition that affects millions worldwide, yet its underlying mechanisms remain only partially understood. Recent research sheds light on the critical roles of phosphoglycerate mutase family member 5 (PGAM5) and adenosine triphosphate (ATP) in the brain, offering new insights into how disruptions in energy metabolism can …

Genetics Predict Suicide Risk in U.S. Army Soldiers (2024 Polygenic Analysis)

by GLOOM

Suicide remains a leading cause of death worldwide, with its prevention a top priority for both public health initiatives and individual care strategies. Recent research in the US Army offers new insights into the genetic underpinnings of suicide attempts, suggesting that polygenic risk scores (PRS) could become a valuable tool in identifying individuals at risk. …

Genetics of Common Executive Function (Cognition) from UK Biobank Data (2023 Study)

by GLOOM

Executive functioning (EF) is a cognitive cornerstone essential for goal-directed behaviors and complex thinking. Recent research leveraging the massive UK Biobank dataset has shed new light on the genetic underpinnings of EF, revealing its distinct genetic profile from intelligence (IQ) and its intricate link with psychiatric disorders. This study underscores the importance of EF in …

T2943 Treats Depression via Epigenetics: HDAC5 Inibitor in Hippocampus (2024 Study)

by GLOOM

Depression remains one of the most pervasive and challenging mental health conditions, affecting millions worldwide with a significant number not responding to traditional treatments. Emerging research underscores the role of histone modifications in depression, pointing towards epigenetic mechanisms as potential targets for novel antidepressants. Specifically, a compound known as T2943 (a histone deacetylase-5 (HDAC5) inhibitor), …

Calorie Restriction (CR) Effects on Brain Gene Expression & Behavior in Rats (2023 Study)

by GLOOM

Calorie restriction (CR) is increasingly recognized for its potential benefits beyond just weight loss, including reducing anxiety, slowing aging, and mitigating the risk of obesity. Recent research focused on how both short-term and long-term CR affect behavior and gene expression in various brain regions, providing insights into the molecular underpinnings of these effects. Highlights: Behavioral …