A 2026 rat study found that 21 days of late-adolescent tetrahydrocannabinol (THC) exposure produced adult anxiety-like behavior in the elevated plus maze and weaker novel object recognition than vehicle exposure. The controlled animal result gives a biologically anchored model for why repeated high-THC exposure during development remains a real concern.1 Research Highlights Late-adolescent THC exposure …
A 12-week text-message intervention for people with schizophrenia spectrum disorders improved diabetes self-management confidence and patient activation, but it did not yet move weight, HbA1c, physical activity, or psychiatric symptoms. SMART looked feasible and psychologically useful in this uncontrolled pilot; cardiometabolic outcomes need a full-scale randomized trial with longer follow-up.1 Research Highlights SMART was tested …
Clozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years — a “third-line, after years of failure” default that a 2026 Current Opinion review by Davani et al. argues is no longer supported by the evidence.1 …
Adding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participants to groups by chance), even though the full 6-infusion ketamine-psychotherapy course was followed by large depression-score reductions. Research Highlights Music added no confirmed MADRS benefit: in the MUSIK …
GLP-1 drugs are usually described as appetite drugs, but a 2026 Nature mouse study mapped a more specific reward circuit: small-molecule GLP-1 receptor agonists suppressed palatable-food intake through Glp1r-expressing central-amygdala neurons that reduced dopamine release in the nucleus accumbens during high-fat-food retrieval.1 That mechanism makes binge-eating and substance-use hypotheses more plausible without turning an animal …
A 2026 IMAGEN stop-signal task analysis found that evidence accumulation, response caution, and go-failure probability predicted cigarette-plus-cannabis use at ages 19 and 23, while inhibition parameters showed no apparent substance-use association.1 The calibrated reading is direct: conventional “poor inhibition” language may be too crude when the cigarette-plus-cannabis signal sits in general decision-making efficiency instead. Research …
A 2026 Neurological Sciences brief communication added 2 Tourette syndrome cases of aripiprazole-related oculogyric crisis — sustained, involuntary upward eye deviation from extraocular-muscle dystonia — after titration to 20 mg and 30 mg daily, with remission after dose reduction.1 Research Highlights 2 new Tourette cases: Cavanna et al. reported oculogyric crisis in females aged 16 …