Patients with chronic insomnia frequently end up on both a sleep medication and cognitive behavioral therapy for insomnia (CBT-I), and a 2026 AASM meta-analysis of 15 RCTs from Buysse et al. found a clear asymmetry: adding CBT-I to medication helps, while adding medication to CBT-I adds little and may even worsen daytime depression scores.1 Research …
A 2026 FAERS pharmacovigilance study of 28,938 dystonia reports found the strongest reporting signal for metoclopramide, while antipsychotics dominated the high-volume psychiatric medication signal and most timed cases began within 30 days of drug exposure.1 Research Highlights 28,938 dystonia reports: Chen et al. analyzed 27,618 patients represented in FAERS reports from Q1 2004 through Q3 …
A 2026 target-trial emulation involving 102,361 U.S. veterans with type 2 diabetes found no increased suicidality risk after starting semaglutide vs. sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors): suicidal ideation HR 0.99 and suicide attempt/death HR 1.05 after overlap weighting.1 That does not prove semaglutide prevents suicide, but it weakens the broad claim that semaglutide initiation itself …
A Global Burden of Disease analysis estimated that U.S. age-standardized substance-use disorder disability-adjusted life-year rates rose 213.5% from 1990 to 2019, with opioid use disorders producing the steepest increase and the largest state-level burden.1 Research Highlights U.S. cases rose sharply: prevalent substance-use disorder cases increased from 12.6 million in 1990 to 19.5 million in 2019.1 …
An 11-person case series tested delayed-release apple cider vinegar capsules in young adults who had gained weight while taking psychotropic medications, and metabolic markers carried more signal than weight loss. Research Highlights Feasibility was the strongest result: 11 of 12 enrolled participants completed the study, 10 of 11 completers missed 5 or fewer doses, and …
A 2026 BRFSS analysis involving 4,071 U.S. adults who used cannabis and either smoked cigarettes, vaped nicotine, or did both found a strong modality match: people who vaped tobacco were much more likely to vape cannabis than to smoke cannabis.1 For addiction and harm-reduction assessment, the pattern is a route-specific risk signal because smoking, vaping, …
Australian coronial data show that fatal poisonings involving new psychoactive stimulants and hallucinogens were rarely single-drug events. In 70 toxicology-confirmed deaths from 2007 through 2025, 92.9% involved other psychoactive drugs and 75.7% involved multiple stimulants or hallucinogens. Research Highlights Fatal cases were usually polysubstance cases: 65 of 70 deaths (92.9%) had psychoactive drugs beyond the …