A 2026 review concluded that GLP-1 receptor agonists have plausible stroke biology and modest prevention signals, but current human evidence does not support routine use as acute ischemic stroke neuroprotection.1 The useful clinical split is prevention in cardiometabolic patients vs. acute brain-rescue treatment after stroke onset. Research Highlights Acute neuroprotection is not established: the 2026 …
A 2025 Science Advances mouse study found a more brain-dependent metformin mechanism than the usual liver-gut framing suggests: low-dose metformin lost its glucose-lowering effect when brain Rap1 signaling could not be reduced, and 36 of 47 ventromedial-hypothalamus SF1 neurons responded directly to metformin.1 Research Highlights Low-dose metformin needed brain Rap1: Control mice lowered glucose after …
A 2026 survey of 467 University of Sydney undergraduate psychology students found that participants generated more and more accurate observable cues for alcohol intoxication than for cannabis intoxication.1 When unanswered cue fields were counted, accurate alcohol cues appeared in 63.2% of possible response slots, while accurate cannabis cues appeared in 37.3%. Research Highlights Alcohol cues …
GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et al. propensity-matched 118,993 GLP-1 RA users to 118,993 non-users in the TriNetX network and found a modest but statistically robust 21–23% higher hazard of new-onset hypersomnolence at 1 and 5 years.1 …
Restless legs syndrome (RLS), now also called Willis-Ekbom disease (WED), is a sleep-disrupting neurologic disorder that affects roughly 20–30% of pregnancies in some series and is linked to preeclampsia, increased cesarean delivery, and perinatal depression. A 2026 Nature and Science of Sleep synthesis turned 9 source documents into 27 practice recommendations across 5 domains, ending …
A 2025 iScience study found that nighttime caffeine increased motor impulsivity in Drosophila, with dose-dependent loss-of-inhibition events across n = 30-32 flies per behavioral condition and stronger effects in female flies than male flies.1 The result does not prove that an evening coffee makes humans reckless, but it sharpens a neglected point: caffeine’s alertness benefit …
A 99-patient randomized trial found that adding esketamine to sufentanil patient-controlled analgesia lowered postoperative depression and anxiety scores at 24 and 72 hours after colorectal cancer surgery, while resting and activity pain scores did not differ by group.1 That pattern makes the result more interesting than simple pain relief: the mood signal was partly independent …