A 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical societal cost reductions (−€2,589 vs. −€2,602), while cost-effectiveness probabilities were only 46% to 59% at trial level but exceeded 80% in the UK.1 The algorithm signal was country-specific and capability-weighted, …
A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …
A 2026 Korean claims analysis of 32,941 women with menopausal disorders found that traditional Korean medicine without recorded acupuncture claims had the lowest 3-year cost and the highest mean quality-adjusted life-year estimate, while acupuncture-inclusive or Western-medicine-inclusive strategies cost more and produced slightly lower QALYs. Research Highlights Lowest-cost group also had the highest QALYs: traditional Korean …
A 2026 analysis linked emotional disorders in heart failure to poorer cardiovascular health, oral-health burden, and oral microbiome dysbiosis, but the strongest mediation signal came from oral health rather than systemic immune-inflammation index.1 In fully adjusted NHANES models, emotional disorders were associated with lower Life’s Essential 8 cardiovascular health, OR 0.39, while self-rated oral health …
A 2026 Generation Scotland study linked traumatic physical injury to diagnosis-stratified blood methylation differences in 4,308 people.1 The clearest recurrent-depression signal pointed toward oxytocin signaling and synaptic-plasticity pathways, but the result is still exploratory pathway evidence rather than a blood test for depression or PTSD. Research Highlights Recurrent depression carried the strongest phenotype signal: traumatic …
A 2026 review of electroacupuncture for depression found a familiar split: mechanistic evidence is rich, but clinical proof remains uneven because representative trials ranged from 65 to 270 participants, used different sham or drug comparators, and often failed to connect stimulation parameters with biological endpoints.1 Electroacupuncture is plausible as a subtype-matched neuromodulation strategy, but it …
A 124-person study of euthymic bipolar disorder found that patients with early systematic antidepressant treatment history had higher negative affect, attentional impulsivity, non-planning impulsivity, and total BIS-11A impulsivity scores than matched patients without that history.1 The association is clinically cautionary, but the cross-sectional design cannot separate antidepressant effects from delayed bipolar diagnosis or more severe …