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Primary Immunodeficiency: Self-Isolation Linked to Depression and Anxiety

MHD card showing a lone figure under a glass dome behind a lit window, with a face mask on the sill and faint immune-cell shapes outside, illustrating a study in which self-isolation was linked to depression and anxiety in adults with immune disorders.

Adults with inborn errors of immunity, also called primary immunodeficiency, who cut back social contact to avoid infections reported more depression and anxiety symptoms. A 2026 German clinic study of 143 patients also found that about 1 in 4 people with significant symptoms had never been diagnosed.1 Research Highlights Isolation went with higher symptom scores: …

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After Teen Suicide Attempts, Stress Ran Both Ways With Parents

MHD card showing a parent and a teen sitting at opposite ends of a sofa in a dim teal room, with a faint arc of amber light beginning to form between them, illustrating interviews in which stress ran both ways between depressed teens and their parents.

When teens with depression were hospitalized after a suicide attempt, they and their parents described stress moving in both directions, from child to parent and back again. That pattern came from separate interviews with 12 teens and 12 of their parents at a psychiatric hospital in China.1 Research Highlights Parents’ moods reached their teens: all …

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Generalized Anxiety Disorder Affects 1 in 5 Psychiatric Outpatients in Japan

MHD card showing a patient silhouette in a dim clinic waiting room holding a clipboard questionnaire, with a red worry spiral above the head, illustrating a Japanese study in which 1 in 5 psychiatric outpatients had generalized anxiety disorder.

About 1 in 5 adults receiving outpatient psychiatric care for mood or anxiety-related conditions in Japan met full diagnostic criteria for generalized anxiety disorder, a 2026 study at 22 clinics found. Most of them had a different main diagnosis on file, usually depression.1 Research Highlights 20.4% had GAD: 83 of 407 outpatients met DSM-5 criteria …

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Subthreshold Depression Linked to Inflammation and Altered Brain Connectivity

MHD card showing a side-view brain with a glowing crimson cingulate arc and a blood vessel releasing small red particles, illustrating a study in which university students with subthreshold depression had altered brain connectivity and slightly higher inflammatory proteins.

University students with subthreshold depression, meaning real depressive symptoms that fall short of a major depression diagnosis, had stronger connections in 3 cingulate brain circuits and slightly higher levels of 3 inflammatory proteins than healthy students, according to a 2026 brain-imaging study from China.1 Research Highlights Stronger cingulate connections: resting brain scans of 126 students …

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