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Subutex vs. Suboxone: What’s the Difference?

Subutex and Suboxone are drugs that were approved by the FDA in 2002 for the treatment of opioid dependence.  Both drugs contain the active ingredient buprenorphine, a semisynthetic opioid that acts as primarily as a partial mu-opioid receptor agonist.  Buprenorphine also acts as an antagonist at the kappa and delta opioid receptors.

Buprenorphine’s mechanism of action mitigates severe withdrawals associated with illicit opioid use, and serves as a “replacement” drug for illicit opioids.  The goal is to help those dependent on illicit opioids transition off of them and onto a replacement therapy like Subutex or Suboxone.  Once a patient has stabilized on the replacement (e.g. Subutex or Suboxone), the next step is to gradually titrate off of the replacement drug, and ultimately for the individual to remain sober.

Although Subutex and Suboxone are similar, the most notable difference between the two is the additional component of Naloxone in Suboxone.  The Naloxone component makes the Buprenorphine component no longer effective past a certain dose (“ceiling effect”), and if crushed or injected, an individual will experience a withdrawal rather than a “high.”  This means that Suboxone has slightly less abuse potential among those with opioid dependence compared to Subutex.

Subutex vs. Suboxone Comparison Chart

As you can see, there really aren’t many differences between Subutex and Suboxone.  The primary difference is that Suboxone contains a unique formulation of 80% buprenorphine and 20% naloxone, whereas Subutex contains only buprenorphine hydrochloride.

Subutex vs. Suboxone

IngredientsBuprenorphine HydrochlorideBuprenorphine (~80%) + Naloxone (~20%)
Drug classificationSynthetic opioid (Partial agonist)Synthetic opioid (Partial agonist)
Approved medical usesOpioid dependence.Opioid dependence.
FormatsSublingual tablet.Sublingual film. Sublingual tablet.
Dosages2 mg or 8 mgSublingual film: 2 mg/0.5 mg or 4 mg/1 mg or 8 mg/2 mg or 12 mg/3 mg

Tablet: 2 mg/0.5 mg or 8 mg/2 mg
ManufacturerReckitt Benckiser PharmaceuticalsReckitt Benckiser Pharmaceuticals
Legal statusSchedule III (US)Schedule III (US)
Mechanism of actionNon-selective mixed agonist-antagonist opioid receptor modulator.

Partial agonist at the mu-receptor. Antagonist at the kappa-receptor. Antagonist at the delta-receptor.

Exhibits high affinity for the sigma-receptor and a minimal affinity for the nociceptin receptor.

Buprenorphine also inhibits voltage-gated sodium channels.
Non-selective mixed agonist-antagonist opioid receptor modulator.

Partial agonist at the mu-receptor. Antagonist at the kappa-receptor. Antagonist at the delta-receptor.

Exhibits high affinity for the sigma-receptor and a minimal affinity for the nociceptin receptor.

Buprenorphine also inhibits voltage-gated sodium channels.

The Naloxone component of Suboxone has a high affinity for the mu-receptor as a competitive antagonist.  It also elicits antagonist effect upon the kappa and delta receptors.
Generic version (?)Yes.Yes.
Half-Life24 to 42 hours.24 to 42 hours.
Common side effectsConstipation. Dizziness. Drowsiness. Headaches.Constipation. Dizziness. Drowsiness. Dry mouth. Lightheadedness. Nausea. Sweating. Vomiting.
Date approved2002 (October)2002 (October)
Duration of effect24 hours (Analgesic: 8 to 12 hours)24 hours (Analgesic: 8 to 12 hours)
Investigational usesChronic Pain.Chronic Pain. Neonatal abstinence syndrome. Treatment-resistant depression. (Read: Suboxone for depression)

Subutex vs. Suboxone: What’s the difference?

These drugs both contain buprenorphine, which means they act as partial opioid agonists, most notably at the mu-receptor.  However, since Subutex does not contain Naloxone, it has a greater potential for abuse and misuse.  Naloxone is a drug that was developed in the 1960s to counteract the effects of opioids, especially in the event of an overdose.

It counteracts opioid effects by functioning as a competitive opioid antagonist, meaning it binds to opioid receptors with a higher affinity than agonists.  After binding to the receptors it prevents activity and thus an individual will feel no opioid-based effects.  Naloxone in particular has a high affinity for the mu-receptor, which offsets the buprenorphine partial agonism, especially when ingested at high doses.

Reckitt Benckiser Pharmaceuticals first developed Subutex, which contained just buprenorphine hydrochloride as the active component.  In effort to further reduce abuse potential and make the drug safer, they formulated the drug Suboxone with both buprenorphine and naloxone at a 4:1 ratio.  For many individuals, Subutex is administered during early stages of opioid replacement therapy, and Suboxone is given during the maintenance phase.

Abuse Potential

Since both Subutex and Suboxone are classified as “Schedule III” controlled-substance, it would be logical to conclude that both have equal potential for abuse.  Schedule III substances are regarded as having less abuse potential than Schedule II drugs and are known to have medically accepted uses. Additionally, Schedule III drugs like Subutex and Suboxone may lead to some physical dependence and significant psychological dependence.

Some speculate that Subutex has a greater potential for abuse than Suboxone, especially when administered at high doses.  The Naloxone component of Suboxone acts as a competitive opioid antagonist with a high affinity for the mu-receptor.  At higher doses, enough Naloxone binds to the mu-receptor and is thought to inhibit additional Buprenorphine mu-receptor stimulation.

Many individuals attempting to abuse Buprenorphine inject it intravenously in attempt to get “high” during opioid replacement therapy.  This intravenous injection is thought to provide individuals with a more potent opioid “high.”  Should an individual attempt to take intravenous Suboxone, the Naloxone component is thought to trigger severe withdrawal symptoms rather than a Buprenorphine-induced “high.”

Evidence suggests that individuals dependent on potent opioids experience an array of unpleasant symptoms should they attempt to administer Suboxone via intravenous injection or intranasal insufflation.  Individuals that are dependent on less potent opioids may not experience as many unpleasant symptoms following intravenous Suboxone administration as those who are highly dependent.  That said, the Naloxone will still mitigate the opioid effect of the Buprenorphine, thus making it unlikely to achieve opioid intoxication.

Among non-dependent opioid abusers, it seems as if Subutex and Suboxone are equal in their abuse potential.  A very small-scale study revealed that high doses of Subutex and Suboxone resulted in similar opioid agonist-like effects.  The researchers suggested that there was not enough evidence to suggest that Naloxone mitigated Buprenorphine’s opioid agonist effects in non-dependent abusers when administered sublingually.

As a recap, Subutex has a significant abuse potential among individuals with opioid dependence and among non-dependent addicts.  Suboxone has less potential for abuse, especially among those dependent upon potent opioids – this is due to the presence of Naloxone.  Among non-dependent abusers, the abuse potential is regarded as being relatively similar.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/10928310
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/20403021
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/25060839

Cost: Which is more expensive?

Those comparing Subutex and Suboxone may want to consider the cost of each medication.  Due to the fact that both drugs contain mostly Buprenorphine as the active ingredient, they are similar.  If you have poor insurance or have to pay out-of-pocket for your medications, you may decide to opt for the least expensive formulation.

Subutex is only manufactured in generic format as “buprenorphine” and can be obtained at a price of $45 to $70 for 30 sublingual 2 mg tablets, and between $75 and $110 for 30 sublingual 8 mg tablets.  Brand name Suboxone can be purchased for a price between $128 and $470 for a 30 sublingual films.  The greater the dosage of the Suboxone films, the greater the cost.

Generic Suboxone (Buprenorphine / Naloxone) can be purchased in the format of sublingual tablets for a price between $75 and $190 for a 30 day supply; the greater the dosage, the higher the cost.  Clearly the cheapest option is Subutex, followed by generic Suboxone tablets, and the most expensive option is brand-name Suboxone films.  Some people may prefer the sublingual films over the tablets and therefore may be willing to pay extra for them.

Dosage & Formats

Subutex is manufactured in the format of sublingual tablets with dosages of 2 mg and 8 mg.  Sublingual tablets are a formulation of the drug that can be placed under the tongue and that dissolve in the mouth.  The dosing options and formats of Subutex are relatively limited by comparison to Suboxone.

Suboxone is manufactured in the format of both sublingual tablets and sublingual film.  The dosing options for the sublingual film are as follows: 2 mg/0.5 mg, 4 mg/1 mg, 8 mg/2 mg, and 12 mg/3 mg.  The first number of each dose indicates the amount of buprenorphine, while the second indicates the amount of naloxone; each dose is engineered to have a 4:1 ratio.

Like the sublingual Subutex tablets, sublingual Suboxone tablets are only manufactured in 2 dosing options including: 2 mg/0.5 mg and 8 mg/2 mg.  There really isn’t much difference in the sublingual tablet dosing options by comparison of Subutex to Suboxone, but there are 2 additional dosing options associated with the Suboxone sublingual film.

Most individuals would agree that sublingual film and sublingual tablets are similar.  Some people may prefer to put a film under their tongue, while others may find the tablets easier to administer; it’s ultimately a personal preference.  Suboxone may be considered advantageous over Subutex due to the fact that it offers multiple sublingual formats and extra dosing increments.

Efficacy: Which drug is more effective?

Everyone wants to know whether Subutex or Suboxone is more effective for treating opioid dependence.  There is no definitive evidence suggesting that one drug is superior to the other in regards to efficacy.  Both contain the active ingredient buprenorphine, which acts as a partial agonist with most of its effect elicited upon the mu-receptor.

Certain individuals may respond better to higher doses of Subutex than Suboxone in early stages of treating opioid dependence.  This is due to the fact that at high doses, it is speculated that Naloxone may counteract some of the mu-receptor stimulation from the Buprenorphine.  Therefore some professionals may initially treat someone with Subutex and transition them to Suboxone after several weeks.

A study published in 2010 analyzed the effects of switching individuals from Subutex to Suboxone.  The study involved 94 participants that were initially treated with 8 mg per day of buprenorphine monotherapy for an average of 840 days.  They were eventually switched to Suboxone (buprenorphine / naloxone) and the outcomes were monitored.

The participants rated their level of satisfaction with Suboxone in respect to management of withdrawal symptoms.  Urinary toxicology data was collected throughout the study and revealed a reduction in positive toxicology tests after switching to Suboxone.  This meant that they were less likely to abuse other drugs (e.g. heroin, cocaine, etc.) on Suboxone than Subutex.

Researchers also discovered that the time between clinic visits was increased with Suboxone compared to Subutex, in part due to less extracurricular drug abuse (as revealed by toxicology reports).  Both drugs are considered well-tolerated, but there may be subtle advantages associated with Suboxone including: reduced abuse potential and reduced likelihood to abuse illicit drugs during treatment of opioid dependence.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/20450243

Mechanisms of action

The mechanisms of action associated with Subutex and Suboxone are nearly the same.  Subutex contains Buprenorphine Hydrochloride, which acts as a partial mu-opioid receptor agonist.  Buprenorphine also elicits effects as a kappa receptor antagonist, delta receptor antagonist, and has a fairly high affinity for the sigma receptor.  It is thought to have a minor affinity for the nociceptin receptor as well and inhibit voltage-gated sodium channels.

Since Suboxone is comprised of 80% buprenorphine, its mechanism of action is nearly identical to that of Subutex.  However, Suboxone was engineered to contain the additional component of Naloxone, which functions as a pure opioid-receptor antagonist.  It has a high affinity for the mu-receptor as a competitive antagonist and modest antagonist effects on kappa and delta opioid receptors.

As a pure antagonist, Naloxone is capable of binding to opioid receptors and ultimately preventing stimulation from opioid receptor agonists.  Since 20% of Suboxone is formulated with Naloxone, it elicits these additional effects, compared to Subutex which solely contains Buprenorphine.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/22504149
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/12435410
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/24903063

Medical Uses

Subutex and Suboxone are FDA approved for the treatment of opioid dependence.  Despite the fact that they are sometimes prescribed off-label to treat chronic pain, they are not technically approved for that condition.  Subutex and Suboxone are different in that Suboxone is considered to have slightly less potential for abuse and therefore is prescribed more frequently as an investigational drug.

Investigational uses for Suboxone include the treatment of neonatal abstinence syndrome and treatment-resistant depression.  Neonatal abstinence syndrome is a condition in which a baby is exposed to opioids via a pregnant mother and experienced withdrawal symptoms when the mother stops using and/or after birth.  Specially formatted Suboxone for infants is currently being studied for this condition.

In rare cases, individuals are prescribed Suboxone as an antidepressant augmentation strategy.  While Suboxone may be highly effective in treating depressive symptoms, it is seldom prescribed due to its lacking of approval and the presence of safer, more established options.  A drug similar to Suboxone called “ALKS-5461” has demonstrated significant efficacy in alleviating depressive symptoms.


Subutex and Suboxone are considered relatively popular drugs in the realm of opioid replacement therapy.  Suboxone is the more popular drug by comparison due to the fact that it is regarded as a safer, upgraded version of Subutex.  From the perspective of a hardcore opioid addicts, Subutex may be the more sought out format of the drug.

That said, among medical professionals, Suboxone is clearly the favorable treatment for opioid dependence.  In part, this popularity is due to the added presence of Naloxone, a component that has been marketed to produce a “ceiling effect.”  This purported “ceiling effect” is thought to prevent any additional “high” or intoxication past a certain dose, making abuse less likely.

In addition, the Naloxone within Suboxone inhibits the intravenous and intranasal potential for a “high” compared to Subutex.  Popularity of Suboxone has largely increased due to the belief that it is both newer and regarded as being a safer treatment for opioid dependence.

Side Effects

Theoretically, the side effect profiles of Subutex and Suboxone shouldn’t be much different.  Common side effects associated with both drugs include: constipation, dizziness, drowsiness, headaches, and nausea.  Some speculate that since Subutex does not contain Naloxone, that it has a favorable side effect profile.

Rationally it would make sense that among individuals sensitive to the effect of Naloxone, side effects may emerge.  There is an extra substance within Suboxone, and therefore is likely an increased potential for side effects.  Examples of common side effects associated with Naloxone include: constipation, dizziness, drowsiness, dry mouth, lightheadedness, and sweating.

The presence of Naloxone may amplify certain side effects derived from Buprenorphine, and may trigger additional side effects.  Naloxone has potential to induce catecholamine release, cause pulmonary edema, and cardiac arrythmias.  For this reason, Subutex may have a slightly favorable side effect profile.

That said, the counterpoint could be made that Naloxone may mitigate certain side effects associated with Buprenorphine. The number and severity of side effects experienced may be subject to significant individual variation.  Some people may report reductions in side effects when taking Subutex, while others may find that they have less side effects on Suboxone.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/17367258


The withdrawal symptoms associated with  Subutex and Suboxone tend to be most severe within the first couple weeks of discontinuation.  Most individuals find that withdrawal gets easier as time continues to pass.  This is in part due to the fact that a person’s neurophysiology is being restored back to homeostatic functioning.

Those that took Subutex or Suboxone for a long-term and/or a high dose are likely to have the most severe withdrawal periods.  Many long-term, high-dose users will experience protracted discontinuation effects in the form of “post-acute withdrawal syndrome” (PAWS) which can last for months (or longer) following the date of discontinuation.  Some individuals may have a tougher time discontinuing Subutex, while others may have a more difficult time coping with Suboxone withdrawal.

Both should produce similar symptoms due to the fact that individuals are primarily withdrawing from Buprenorphine.  While users may not experience any withdrawal symptoms from the Naloxone component, to suggest that there’s no discontinuation effect (even if undetectable) from Naloxone is relatively short-sighted.  Certain individuals may have a slightly easier time discontinuing Subutex for this reason.

Similarities (Recap): Subutex vs. Suboxone

Listed below are the similarities shared between Subutex and Suboxone.

  • Drug type: Subutex and Suboxone are regarded as semisynthetic opioids and are first-line treatments for opioid dependence.
  • Duration of effect: The duration of effect associated with these drugs is 24 hours, with a 8 to 12 hour analgesic window.
  • Efficacy: Subutex and Suboxone are regarded as having nearly identical efficacy due to the same dosage content of buprenorphine.
  • Generic availability: Generic formats are available for both drugs. Subutex is manufactured as “buprenorphine hydrochloride” and Suboxone is sold as “buprenorphine/naloxone.”
  • Half-life: The elimination half-life for both drugs is thought to range between 24 and 42 hours.
  • Legal status: Both drugs are classified as “Schedule III” controlled-substances.
  • Medical uses: Both medications have been FDA approved for the treatment of opioid dependence.
  • Manufacturers: Reckitt Benckiser Pharmaceuticals is responsible for manufacturing both Subutex and Suboxone.
  • Withdrawal: Discontinuation from Subutex and Suboxone is thought to be relatively difficult. There is no evidence that discontinuation from one is more or less severe than the other.

Differences (Recap): Subutex vs. Suboxone

Listed below are some differences between Subutex and Suboxone.

  • Abuse potential: Despite classification of both substances as “Schedule III” – Suboxone may have slightly less abuse potential among individuals with opioid dependence. This reduced abuse potential stems from the ingredient naloxone, which triggers unfavorable symptoms when intravenously injected or insufflated.
  • Cost: Purchasing generic Subutex is regarded as cheaper than generic Suboxone. Purchasing brand name Suboxone is more expensive than the respective generic formulations.
  • Formats: Subutex is manufactured in the format of sublingual tablets, whereas Suboxone can be taken in the formats of sublingual films or sublingual tablets.
  • Ingredients: Subutex is comprised of buprenorphine hydrochloride, while Suboxone contains buprenorphine and naloxone.
  • Investigational uses: Subutex isn’t known to have any investigational uses, whereas Suboxone has been investigated for treating neonatal abstinence syndrome and refractory depression.
  • Mechanisms of action: While both drugs primarily act as partial mu-receptor agonists as a result of the buprenorphine content, a slight mu-receptor antagonist effect is triggered as a result of naloxone in Suboxone. This effect is not present in Subutex.
  • Side effects: The side effects associated with both drugs are thought to be relatively similar due to the fact that buprenorphine is the primary active ingredient. There may be increased propensity for side effects with Suboxone due to its naloxone content.
  • Popularity: Among medical professionals, Suboxone remains the more popular drug than Subutex. This increase popularity results from the fact that Suboxone is thought to have less abuse potential.

Which drug is a better opioid replacement therapy? Subutex vs. Suboxone.

Anecdotal reports across the internet may claim that Subutex is better than Suboxone, while others may claim the opposite.  There is some evidence that the presence of naloxone within Suboxone may result in more favorable opioid withdrawal symptoms during the transition from an illicit drug (e.g. heroin) to the replacement.  This favorable mitigation of withdrawal symptoms during the transition may be due to the presence of naloxone.

One study involving patients transitioning from Subutex to Suboxone noted that after 2 weeks of Suboxone usage, participants were less likely to abuse illicit opioids.  They were able to detect a reduction in illicit opioid abuse as a result of toxicology data collected.  Some people like the fact that Suboxone is manufactured in multiple formats (sublingual film and sublingual tablet) compared to Subutex which is only sold in the format of sublingual tablets.

In terms of side effects, some individuals may respond slightly better to Subutex due to the fact that it contains zero naloxone, while others may respond better to the Suboxone as a result of the naloxone content.  In some cases, a doctor may prescribe Subutex in early stages of opioid replacement therapy and transition a patient to Suboxone after a couple weeks.  This is due to the fact that Suboxone is less likely to be abused, particularly intravenous or intranasal due to the naloxone content.

Some have argued that the naloxone content within Suboxone was mostly added for marketing purposes and that it doesn’t really provide a “ceiling effect” or reduce abuse potential.  This speculation has to do with the fact that the patent expired for Subutex, whereas the patent had not expired for Suboxone.  This may have lead the developers to create a campaign suggesting that their revised formulation of Suboxone is favorable to the generic Subutex.

Ultimately there is some evidence to suggest that Suboxone may be the safer option with reduced abuse potential when compared to Subutex.  For this reason, Suboxone is generally regarded as the superior option for the treatment of opioid dependence.  However, cost differences and unfavorable side effects associated with naloxone may prompt some patients to request Subutex over Suboxone.

Which drug do you prefer: Subutex or Suboxone?

If you have experience using both Subutex and Suboxone, feel free to share a comment regarding any differences you noticed between the two drugs.  Specifically, you may want to mention whether you experienced an increased number of unfavorable side effects while taking one drug compared to the other.  If you’ve had the experience of withdrawing from both, mention whether one was easier than the other.

Keep in mind that some perceived differences between the two drugs may be due to: naloxone content, dosage differences, a nocebo effect, and/or subjectivity.

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4 thoughts on “Subutex vs. Suboxone: What’s the Difference?”

  1. Cannot wait to switch from 24 mg’s daily of Suboxone to Subutex. I was never an IV user, never will be, so why I am putting doses of Nalaxone in me for no reason….

    • I agree. I have been being lied to by a doc in the Caribbean who said when my severe arthritis has been bothered by a big job or moving to a new house and lifting heavy things take more Subutex. In the states the doc I went to said only Suboxone could be subscribed and acted like I was asking for oxycontin when I wanted 15 Subutex. So in May I was prescribed 30 Subutex (still in caribbean) at 2- 8 mg per day.

      I was supposed to raise to 3 since my back was acting up. THAT WAS IT!!! This doc was after $150.00 cash only per month and lied about it helping arthritis pain, hid cash from taxes obviously, and was hoping I never quit. I learned from a friend that you don’t just work your way down to 1/4 pill and quit. I had terrible stomach cramps and couldn’t pee.

      I tried crumbs of Subutex like my friend said and immediately felt like a champ! So I will stay on crumbs for a while and finally try abstinence. The new doc in late July in America prescribed Suboxone like I said and the first crumb I noticed hot flashes. I will try it a while and hope they stop. I could have gotten 60- pills and only asked for 15. I doubt I will need all before quitting.

      The pharmacy was out of pills and tried to sneak me films but I returned them (only bought 3) pills from another pharmacy. Suboxone was more expensive and I pay cash. Does the doc really think I appeared an abuser after showing him the bottle dated 5-5-16, 30 Subutex. Take 2 a day. It was actually July 25th and all I asked for was 15 and now have to suffer side effects for more money and a $300.00 doc bill. REMEMBER TO TAPER DOWN TO CRUMBS.

      That small dose wears off by before bedtime so in AM 1st thing I will take crumb and hope hot flashes go away after it takes effect or might go back and complain… Imagine trying that with film!!! Your dose might blow away before it gets under your tongue and how do you store 1/10th of a film?I paid $300.00 for that ignorant, incompetent, selfish service. Then asked for SOMA for nighttime back pain to sleep and doc said no way.

      I don’t trust doctors and use Swedish Flower Pollen at $15.00 per month instead of Flomax for urinary retention (I’m 63) and it’s a normal thing for us older farts. Doctors hate it when we study up and learn a cheaper more healthy way to cure a problem. By the way, the new Suboxone prescription says take 1/2 pill per day!!!

      In other words raise the dose after already tapering to crumbs yet he moved me to Suboxone so I wouldn’t shoot up or abuse it? THERE ARE SIDE EFFECTS TO NALOXONE IN MY CASE BUT I JUST HAVE TO SUFFER. Thats what I get for taking oxycontin after 2 total knee replacements, 2 back discs bone to bone and 2 in the neck.Stand up for your rights if you have experience and know what you are talking about.

      The docs think we are all trying to scam a high and don’t know how to treat an honest person presenting proof he is quitting and Docs come up with some crazy excuses. Sometimes crumbs wear off before sleep, stomach cramps slowly appear and have to take crumbs before sleep. Be prepared to toss and turn all night and watch the alarm clock go off in the AM, then take more crumbs. I’m guessing a month of crumbs after 6 years of 16 mg per day might work and will report in 45 days on side effects of Suboxone, and hopefully don’t have to use crumbs for 6 months.

      Also, what if emergency broken bone while on Suboxone verses Subtex? I read EMS can give a massive dose of opiate to kill pain safely but can’t imagine one doing it. I even read incase you can’t talk, wear a sign saying there is Naloxone in your system. That will definitely keep the opiate drawer closed and locked and you in pain. They just don’t care simply due to lack of knowledge. By 3000 they will all know, if the earth is even worth living on then.

  2. Thank you to the person who posted before me for highlighting the FACT that Buprenorphine itself is the blocker. RB used this naloxone nonsense in order to achieve a new patent just like they did with the films. How can naloxone block the effect of injecting buprenorphine when buprenorphine has a HIGHER BINDING AFFINITY? This is also why it is extremely hard to reverse a buprenorphine overdose for individuals who are not opioid tolerant.

    Funny how do many medical “professionals” cannot even figure this out. Maybe because they are only required to take an eight hour course in order to prescribe the medication for maintainence. I’ve witnessed dope-sick Heroin addicts inject both sublingual pills and film (Suboxone) with no adverse affects whatsoever. Simple pharmacology should’ve prevented anything beyond Subutex even being approved. Follow the money.

    This drug is a life saver though, kept me off of Heroin for Seven years until I decided to Taper off after getting sober through a twelve step program. And therapy. The lack of information out there is appaling. Methadone is terrible, I’ve been there done that. Nice to not have to show up at a clinic like site sort of animal every day and get hooked on a worse drug than the one you came in to get off of.

    I’ve tapered from 16/mg per day after two years initially and did it at a rate of 20% dose reduction of my CURRENT DOSE every five days. Mild flu like symptoms. Talk to anyone who’s come off of 150/mg of methadone per day and they’ll tell you it was the worst experience of their life. I find this site to be lacking knowledge in terms of pricing/dosages and the aforementioned topics.

    Like somebody reading a PDR wrote the articles. I’ve never had any price increase (no matter the drug and I’ve been prescribed plenty), due to the dosage amount, only quantity. This is in the U.S. I pay cash.

  3. I won’t go into my history too much just to say that suboxone improved my life by thousand times. I wasn’t introduced it in treatment I originally got it off the street to avoid withdraw. It work like magic and slowly I began to self medicate and avoid all other opiates because it became a waist of money as the bupenorphine blocks the effects of other opiates.

    I thought at first it was the Naloxone but after taking subutex and not getting opiate effects I looked into and found out that bupenophine is a blocker. I eventually got a doctor and medicated legally. I did notice differences between the two. Suboxone definately makes you break out into sweats that is one thing that seems objective about the comparison. The other differences maybe more mental.

    After taking subutex I felt like I had a better state of mind, not quite euphoria but better than suboxone. I have never gotten high on either one no matter how much I took. From what I understand bupenorphine – because it is only a partial agonist – is what creates the ceiling effect. I assume this only the case with tolerant people as I have seen others get quite high, but most get sick or just don’t like it.


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