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Zubsolv vs. Suboxone: What’s the Difference?

There are many new medications that have been engineered specifically for the treatment of opioid dependence.  Those dependent on opioids tend to experience debilitating physical and psychological withdrawal symptoms upon discontinuation.  To help individuals discontinue illicit opioids like heroin, an “opioid replacement therapy” drug is often prescribed.

Two of the most common opioid replacement therapy drug options include Zubsolv and Suboxone.  Suboxone is a drug that hit the market in 2002 as a treatment for opioid dependence.  It differed from previous opioid replacement therapy drugs in that it was formulated with a 4:1 ratio of buprenorphine to naloxone.

The buprenorphine was thought to elicit partial agonist effects on the mu-receptor, while the naloxone was included in the formulation to limit abuse potential.  Zubsolv is similar to Suboxone in that it contains both buprenorphine and naloxone at approximately 4:1 ratios.  However, Zubsolv is considered an improvement over Suboxone in that it has a higher bioavailability, faster dissolve time, and smaller tablet size by comparison.

Zubsolv vs. Suboxone Comparison Chart

The chart below highlights the general characteristics of both Zubsolv and Suboxone.  Both drugs contain the same active ingredients and are administered sublingually.  They are manufactured by different companies and are known to differ in dosing options.

Zubsolv vs. Suboxone

IngredientsBuprenorphine (~80%) + Naloxone (~20%)Buprenorphine (~80%) + Naloxone (~20%)
Drug classificationSynthetic opioid (Partial agonist)Synthetic opioid (Partial agonist)
Approved medical usesOpioid dependence.Opioid dependence.
FormatsSublingual tablet.Sublingual film. Sublingual tablet.
Dosages0.7 mg/0.18 mg or 1.4 mg/0.36 mg or 5.7 mg/1.4 mg or 8.6 mg/2.1 mg or 11.4 mg/2.9 mg.Sublingual film: 2 mg/0.5 mg or 4 mg/1 mg or 8 mg/2 mg or 12 mg/3 mg

Tablet: 2 mg/0.5 mg or 8 mg/2 mg
ManufacturerOrexo PharmaceuticalsReckitt Benckiser Pharmaceuticals
Legal statusSchedule III (US)Schedule III (US)
Mechanism of actionNon-selective mixed agonist-antagonist opioid receptor modulator.

Partial agonist at the mu-receptor. Antagonist at the kappa-receptor. Antagonist at the delta-receptor.

Exhibits high affinity for the sigma-receptor and a minimal affinity for the nociceptin receptor.

Buprenorphine also inhibits voltage-gated sodium channels.

The Naloxone component of Zubsolv has a high affinity for the mu-receptor as a competitive antagonist.  It also elicits antagonist effect upon the kappa and delta receptors.
Non-selective mixed agonist-antagonist opioid receptor modulator.

Partial agonist at the mu-receptor. Antagonist at the kappa-receptor. Antagonist at the delta-receptor.

Exhibits high affinity for the sigma-receptor and a minimal affinity for the nociceptin receptor.

Buprenorphine also inhibits voltage-gated sodium channels.

The Naloxone component of Suboxone has a high affinity for the mu-receptor as a competitive antagonist.  It also elicits antagonist effect upon the kappa and delta receptors.
Generic version (?)No.Yes.
Half-Life24 to 42 hours.24 to 42 hours.
Common side effectsConstipation. Dizziness. Drowsiness. Dry mouth. Lightheadedness. Nausea. Sweating. Vomiting.Constipation. Dizziness. Drowsiness. Dry mouth. Lightheadedness. Nausea. Sweating. Vomiting.
Date approved2013 (July)2002 (October)
Duration of effect24 hours (Analgesic: 8 to 12 hours)24 hours (Analgesic: 8 to 12 hours)
Investigational usesChronic Pain.Chronic Pain. Neonatal abstinence syndrome. Treatment-resistant depression. (Read: Suboxone for depression)

Zubsolv vs. Suboxone: What’s the difference?

The primary difference between Zubsolv and Suboxone is the bioavailability of each drug.  Zubsolv is regarded as having a significantly greater bioavailability than Suboxone.  This means that when you take Zubsolv, the percentage of the drug that has an active effect is greater than that of Suboxone.

The active ingredients of both drugs include buprenorphine and naloxone.  These ingredients are present at exact 4:1 ratios in Suboxone and approximate 4:1 ratios in Zubsolv.  Since your body uses Zubsolv more efficiently than it uses Suboxone, it takes a greater dose of Suboxone to elicit the same effect as a lower dose of Zubsolv.

In addition, the Zubsolv sublingual formulation dissolves quicker under the tongue than Suboxone and includes a menthol (mint) flavor.  Many individuals and doctors regard Zubsolv as an “upgraded” version of Suboxone.  Although Suboxone remains a popular opioid replacement therapy option, many believe that the competitor drug Zubsolv is a superior formula.

Abuse Potential

Zubsolv and Suboxone are regarded as “Schedule III” controlled-substances, meaning they have equal potential for abuse.  Schedule III drugs tend to have reduced potential for abuse compared to those considered “Schedule II” and are known to have medically accepted uses.  It is known that Schedule III substances like Zubsolv and Suboxone may cause dependence physical and psychological dependence.

Both of these formulations contain buprenorphine and naloxone.  By itself, buprenorphine is regarded as one of the most addictive drugs; its addiction rating is “1.64” on a scale from 0 to 3.  However, since naloxone is included in each of the formulations, it limits potential for abuse, especially by those that attempt to intravenously inject or snort (insufflate) either drug.

Should an individual intravenously inject or intranasally insufflate either Zubsolv or Suboxone, the naloxone component is thought to mitigate any “high” that a person would’ve received from the buprenorphine component.  While buprenorphine stimulates the mu-receptor as a partial agonist, naloxone acts as a competitive mu-receptor antagonist and serves as a built-in safety mechanism.

As an antagonist, the naloxone binds to the mu-receptor and inhibits any agonist stimulation from the buprenorphine, thus sending the individual into full-blown withdrawal.  Individuals that were dependent on highly-potent opioids that attempt to abuse Zubsolv or Suboxone may experience unpleasant symptoms.  Those that were dependent on less potent opioids may not experience unpleasant symptoms, but are unlikely to derive any “high” from either drug.

The potential for abuse of Zubsolv and Suboxone is considered high among those who aren’t physically dependent on opioids.  Since both drugs contain “naloxone” their potential for abuse is lower than formulations without it (e.g. Subutex).  Neither Zubsolv nor Suboxone should be considered to have any greater potential for abuse compared to the other; their ingredient composition is nearly identical.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/10928310
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/20403021
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/25060839

Cost: Which is more expensive?

Those considering Zubsolv and Suboxone as potential opioid replacement therapy options may also want to consider the price of each drug.  Individuals without good insurance coverage may end up having to pay for a prescription out-of-pocket and therefore probably will want to chose the most affordable option.  The cost for a 30 day supply of Zubsolv ranges between $221 and $240.

Due to the fact that Zubsolv wasn’t approved until 2013, a generic will not be available for awhile.  Therefore if you’re getting Zubsolv without insurance, the associated costs can get quite expensive.  The cost for a 30 day supply of “brand name” Suboxone sublingual films will cost between $130 and $470; the higher the dosage, the greater the cost.

Fortunately, Suboxone is sold under the generic “buprenorphine / naloxone” ranging between $75 and $190 for a 30 day supply.  This means that if you’re looking to save yourself money, the generic Suboxone is probably your best option.  Zubsolv tends to be more expensive than certain doses of brand name Suboxone, but at the highest doses, Suboxone may be more expensive.

Dosage & Formats

Zubsolv is manufactured in a sublingual tablet format with a variety of dosages including: 1.4 mg/0.36 mg, 5.7 mg/1.4 mg, 8.6 mg/2.1 mg and 11.4 mg/2.9 mg.  The first number associated with each pill is the dosage of buprenorphine, while the second number reflects the dosage of naloxone.  As you can see, each pill contains an approximate (but not exact) 4:1 ratio of buprenorphine to naloxone.

Suboxone is manufactured in multiple formats including sublingual films and sublingual tablets.  The sublingual Suboxone films have dosages of: 2 mg/0.5 mg, 4 mg/1 mg, 8 mg/2 mg, and 12 mg/3 mg.  The generic sublingual Suboxone tablets are manufactured with only 2 dosing options of 2 mg/0.5 mg and 8 mg/2 mg.  The first number in each formulation reflects the buprenorphine dose, while the second reflects the naloxone.

As you can see, the ratio of buprenorphine to naloxone in Suboxone is exactly 4:1.  The dosage ratios differ in Zubsolv such as: 3.8 to 1, 4.07 to 1, 4.09 to 1, and 3.93 to 1 (from lowest dose to highest).  That said, Zubsolv’s is manufactured in 4 doses to match the 4 dosing options of Suboxone.  The only difference between the two is that Suboxone is manufactured in sublingual “films” and “tablets” whereas Zubsolv is only manufactured in sublingual “tablets.”

Each dose of Zubsolv is thought to be calibrated to elicit similar potency as higher doses of Suboxone.  For example, the Zubsolv 8.6 mg/2.1 mg is thought to correspond with the 12 mg/3 mg of Suboxone.  Some individuals may like the idea of taking a lower dosage that has a higher bioavailability (Zubsolv) compared to a higher dosage with a lower bioavailability (Suboxone).

Efficacy: Which drug is more effective?

Due to the fact that Zubsolv has a greater bioavailability than Suboxone, a lower dose can be taken to achieve the same effect as a higher dose of Suboxone.  The percentage of Zubsolv that has an effect is greater than the percentage of Suboxone that has an effect.  Every dosing option of Zubsolv is equivalent to a higher corresponding dosage of Suboxone.

For example, the Zubsolv 1.4 mg/0.36 mg is equivalent to the Suboxone 2 mg/0.5 mg.  Similarly the Zubsolv 5.7 mg is equivalent to the Suboxone 8 mg and the Zubsolv 8.6 mg is equivalent to the Suboxone 12 mg.  There is even a higher dose of Zubsolv 11.4 mg/2.9 mg that would be equivalent to a Suboxone 16 mg if it was manufactured.

The onset of action is quicker for Zubsolv due to the fact that it dissolves sublingually in seconds rather than minutes like Suboxone.  It also may have a slightly longer duration of effect by comparison.  Clearly Zubsolv is the more potent drug due to its enhanced bioavailability and as a result, it may be slightly more effective than Suboxone.

That said, the difference in efficacy is unlikely to be significant in a head-to-head comparison.  If dosage equivalencies were taken into account, the efficacy in treating opioid dependence should be nearly identical.  Subtle differences may result from the ratios of buprenorphine to naloxone, which differ slightly in Zubsolv based on dose compared to Suboxone.

If the naloxone component offsets some of the buprenorphine, the lowest dose (1.4 mg/0.36 mg) and the highest dose of Zubsolv (11.4 mg/2.9 mg) have ratios of less than 4:1 buprenorphine to naloxone, which may make them slightly less effective than Suboxone; this is assuming the naloxone elicits a slight antagonist effect.  However, the middle doses of Zubsolv including the 5.7 mg/1.4 mg and 8.6 mg/2.1 mg may be slightly more effective than Suboxone due to greater than 4:1 ratios of buprenorphine to naloxone.

Mechanisms of action

The respective mechanisms of action associated with Zubsolv and Suboxone are the same.  The buprenorphine component of each drug functions primarily as a mu-opioid receptor partial agonist.  This produces less of an opoioid effect than a full agonist, but still may result in sedation, reduced blood pressure, analgesia, euphoria, nausea, and relaxation.

The primary benefit derived from these drugs is a result of the buprenorphine, hence it accounts for nearly 80% of each formulation.  The buprenorphine also acts as a kappa receptor and delta receptor antagonist, meaning it inhibits stimulation at these sites.  In addition, it is known to have a subtle affinity for the nocioceptin receptor and is capable of blocking various voltage-gated sodium channels.

The remaining 20% of Zubsolv and Suboxone formulations is comprised of naloxone.  Naloxone is a drug that acts as a pure opioid-receptor antagonist.  It acts primarily as a competitive antagonist at the mu-opioid receptor and acts as a moderate antagonist at kappa and delta opioid receptors.  The effect of naloxone is thought to mitigate abuse and prevent excess intoxication as a result of the buprenorphine.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/22504149
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/12435410
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/24903063

Medical Uses

Zubsolv and Suboxone are drugs solely approved by the FDA for the treatment of opioid dependence.  They are not formally approved to treat chronic pain, despite the fact that they may be approved off-label for this purpose.  Both drugs are regarded as being significantly more effective than a placebo in double-blind, randomized, clinical trials for the treatment of opioid dependence.

Due to the fact that Suboxone has been on the market for a longer period of time, it has been investigated for the treatment of neonatal abstinence syndrome.  This is a condition in which a baby was exposed to opioids during pregnancy and experiences withdrawal symptoms while in the womb or following birth.  Specially engineered neonatal Suboxone is being investigated by the FDA for the treatment of this condition.

Furthermore, some doctors may prescribe Suboxone as an antidepressant augmentation strategy for individuals suffering from refractory depression with a history of opioid dependence.  Many anecdotal reports suggest that it is significantly more effective than standard antidepressant options.  A drug similar to Suboxone called “ALKS-5461” which contains buprenorphine and samidorphan has shown promise as an adjunct treatment in cases of refractory depression.

Suboxone is more commonly prescribed off-label compared to Zubsolv and has been investigated for the treatment of neonatal abstinence syndrome and depression.  Zubsolv is a relatively new drug and therefore hasn’t gained as much widespread off-label use nor investigational use by comparison.  That said, the outcomes associated with using either drug should be nearly identical.


In the mainstream, Suboxone remains the more popular opioid replacement therapy option.  Some would argue that there’s a battle between Methadone and Suboxone for the top opioid replacement therapy drug.  That said, doctors have recognized that Suboxone is likely safer than Methadone due to its decreased potential for addiction and reduced potency as a partial mu-receptor agonist.

Since Suboxone also contains naloxone, it is thought to have a reduce potential for abuse.  The reduced abuse potential is appealing to professionals.  Although Zubsolv isn’t yet as popular as Suboxone or Methadone, it is gaining momentum.  Professionals are starting to recognize that its higher bioavailability and quicker absorption make it superior to Suboxone; this should bolster Zubsolv’s popularity in forthcoming years.

Among patients that have tried both Suboxone and Zubsolv, most prefer Zubsolv for a number of reasons.  Most individuals like the fact that Zubsolv dissolves quickly – in seconds rather than minutes associated with Suboxone.  The Zubsolv tablets also are very small and provide a menthol, minty flavor which many individuals prefer over Suboxone.

Side Effects

The side effect profiles of Zubsolv and Suboxone aren’t much different.  This is due to the fact that both contain approximately 80% buprenorphine and 20% naloxone.  Common side effects associated with these medications include: constipation, dizziness, drowsiness, headaches, and nausea.

Due to the fact that both drugs contain the same active ingredients, there shouldn’t be many differences in side effects from Zubsolv compared to Suboxone.  Some claim that since Zubsolv is more efficiently absorbed that side effects are less likely; whether this is true is unknown.  Those experiencing side effect differences on one drug compared to the other are likely placebo-related.

If you experience more side effects on one drug compared to the other, it may have to do with the dosing.  As was already mentioned, lower doses of Zubsolv correspond with higher doses of Suboxone.  The higher the dose of either drug that you’re taking, the more likely you’ll be to experience side effects.  Subtle differences in perceived side effects may be due to slight increases or decreases in the ratio of buprenorphine to naloxone as occur in Zubsolv.


The discontinuation process associated with Zubsolv and Suboxone can be difficult.  In fact, many claim that discontinuing these medications is nearly as difficult as discontinuing more potent opioids.  This is due to the fact that many individuals stay on Zubsolv or Suboxone for an extended duration of time without making any effort to reduce their dosage.

The longer the time span over which a person takes either of these drugs, the more difficult the discontinuation process will be.  There are many anecdotal reports highlighting the difficulty of Suboxone withdrawal, but not as many discussing Zubsolv withdrawal due to the fact that it is a newer drug.  Both drugs should theoretically have the same degree of difficulty in regards to withdrawal.

Since both drugs are manufactured in 4 dosing options, the tapering process shouldn’t be considered more or less difficult with one drug compared to the other.  Many individuals discontinuing from high doses may experience post-acute withdrawal syndrome (PAWS).  This means that withdrawal symptoms may linger for months following the date of discontinuation from either drug.

Similarities (Recap): Zubsolv vs. Suboxone

Below is a recap of the similarities shared between Zubsolv and Suboxone.

  • Abuse potential: Both drugs are considered to have a minimized potential for abuse when used in accordance to medical recommendations.
  • Dosages: Each drug is manufactured with four dosing options. While the dosages differ in milligrams of buprenorphine and naloxone, most are equivalent in potency.
  • Drug type: Zubsolv and Suboxone are considered semisynthetic opioids and are regarded as first-line treatments for opioid dependence.
  • Duration of effect: With both drugs, the duration of effect is thought to be 24 hours, with an 8 to 12 hour analgesic effect.
  • Efficacy: The efficacy associated with Zubsolv is no different than that of Suboxone when dosages are properly calibrated.
  • Half-life: The associated half-life of elimination for both drugs is between 24 and 42 hours.
  • Ingredients: The ingredient composition associated with these drugs is identical with approximately 80% buprenorphine and 20% naloxone.
  • Legal status: Both drugs are classified as “Schedule III” controlled-substances.
  • Mechanisms of action: These drugs have the same mechanisms of action as a result of identical ingredients and nearly identical contents of buprenorphine and naloxone.
  • Medical uses: Each drug has been granted FDA approval to treat opioid dependence.
  • Side effects: The side effect profile of Zubsolv and Suboxone should be identical. Common side effects include dizziness, dry mouth, nausea, and sweating.
  • Withdrawal: Discontinuation of either drug will result in withdrawal symptoms. There is no evidence to suggest that the difficulty of withdrawal is greater with one drug than the other.

Differences (Recap): Zubsolv vs. Suboxone

Below is a synopsis of some differences between Zubsolv and Suboxone.

  • Aftertaste: Zubsolv has a built-in “menthol” flavoring which leaves a minty aftertaste following sublingual administration. Many individuals dislike the taste of Suboxone or find that it lacks any flavor.
  • Bioavailability: Zubsolv has a significantly greater bioavailability than Suboxone (approximately 1.4 times). This means that a lower dose of Zubsolv delivers the same effect as a higher dose of Suboxone.
  • Cost: Buying a 30 day supply of generic Suboxone is cheaper than Zubsolv. Purchasing brand name Zubsolv is more expensive than lower-dose Suboxone, but cheaper than higher-dose Suboxone.
  • Dissolving speed: Zubsolv proved in clinical trials that it dissolved significantly faster sublingually than Suboxone. Zubsolv dissolves in seconds, whereas Suboxone dissolves in minutes.
  • Formats: Both drugs are available in sublingual tablet format, but Suboxone is also manufactured in the form of sublingual “films.”
  • Generic availability: Suboxone is manufactured in the generic form of “buprenorphine / naloxone” whereas Zubsolv remains patent-protected.
  • Investigational uses: Suboxone has been subject to significantly greater investigational use including: neonatal abstinence syndrome and depression, whereas Zubsolv has not.
  • Manufacturers: Reckitt Benckiser Pharmaceuticals manufactures Suboxone, and Orexo Pharmaceuticals manufactures Zubsolv.
  • Onset of action: Zubsolv has the quicker onset of action as a result of its faster dissolve time.
  • Popularity: Suboxone remains more popular than Zubsolv due to the fact that it has been on the market since 2002, whereas Zubsolv didn’t enter the market until 2013.

Which drug is a better at treating opioid dependence? Zubsolv vs. Suboxone.

Neither Zubsolv nor Suboxone should be regarded as a superior in efficacy when compared to the other.  Both are effective options for the treatment of opioid dependence and the respective formulations are nearly identical.  Zubsolv is regarded as a newer drug, and therefore may be preferred by doctors and patients alike for the treatment of opioid dependence.

Scientific evidence suggest that Zubsolv has nearly 1.4 times the bioavailability as Suboxone, it dissolves significantly quicker (seconds rather than minutes), and it leaves a preferable (menthol) aftertaste in the mouth following sublingual administration.  While nothing really changed in terms of ingredients or efficacy, there are some “upgrades” associated with Zubsolv compared to Suboxone.

For these upgrades such as the: increased bioavailability, quicker onset of action (faster dissolve time), and superior aftertaste – you will pay extra.  The cost of Zubsolv is significantly greater than generic Suboxone.  It will also cost more than low doses of brand name Suboxone.  If you are taking high doses of brand name Suboxone, Zubsolv is actually a bit cheaper.

Which drug do you prefer: Zubsolv or Suboxone?

If you have taken both Zubsolv and Suboxone, be sure to share a comment regarding your preference for one drug over the other.  If you prefer Zubsolv, is it due to the fact that it dissolves quicker or tastes better?  If you subjectively experienced less side effects or a longer duration of effect associated with one drug or the other – mention that too.

If you believe that Zubsolv is more effective than Suboxone or vice-versa, were you on an equivalent dose?  Experiencing greater efficacy with one drug over the other may be a result of the specific dose you were taking.  Understand that any perceived differences between the two drugs may be a result of: subjectivity, nocebo effects, and/or subtle variations in buprenorphine to naloxone ratios.

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21 thoughts on “Zubsolv vs. Suboxone: What’s the Difference?”

  1. I was switched from Suboxone 8/2 twice a day to Zubsolv 5.7/1.4. It was an abrupt switch. Supposed insurance issue. Listen I have been on Suboxone for over ten years. I have always gone to a doctor of course paying $150-250 each month. Unfortunately I have had the worst month.

    I was in a constant state of withdraw. Even increasing my dose from one to two a day. Still extreme up and downs, sweating burning inside to cold, anxious, nauseous, frustrated low energy. I called my doc just to be told “they are exactly the same”. What??? Let me be real honest there was a major difference between the meds.

    Besides the better taste nothing was better. I went from highly productive to BARLEY tiding up around the house. My fiancee was having a hard time understanding my behavior. This is a sickness only understood by those who have been thru it. Maybe a close caregiver may also have some insight. I was shocked by my NEW doctors attitude.

    I listened to all my doctors. I follow orders. I just spent almost a month suffering with withdraw symptoms. I had to take 2 Zubsolv where I only was prescribed one morn night. But I still felt bad. Last night my doc reluctantly gave me a script for Suboxone. I paid out of pocket.

    ABOUT 25 MIN LATER. I WAS FEELING NORMAL. BESIDES THE TRAUMA OF BEING SICK FOR SO LONG ON MY BODY, I FEEL SO MUCH BETTER!!! I never leave comments. However I thought I would speak up. Zubzolv is new. No doctor should tell you how you feel. It’s just not the same drug as mentioned.

    I don’t know the scientific reason. Believe me I had faith and would have liked it to work. Less drug better all around. But it wasn’t like that. I’m not saying that you shouldn’t try it. I just felt strongly about sharing my experience. Since this drug has less information due to it’s newness on the market. Good luck. I wish you you continued health. God bless.

  2. I find any comment that mentions the preferred taste of the Zubsolv as a reason to prefer it over Suboxone, very suspicious, i.e “My life vest doesn’t float as good as yours, but I love the color”. I’m about to switch to Zub after 10 years of sobriety on Suboxone. I’m very anxious but the insurance company has decided they know what’s best.

  3. I’ve taken both suboxone & zubsolv before & I 100% prefer zubsolv over suboxone because the menthol taste tastes good & it dissolves really quick. Plus I did way better on zubsolv, I was able to collect more clean time on zubsolv. Zubsolv is definitely the new best thing. If you have the option to choose suboxone or zubsolv- get zubsolv!

  4. I have been on suboxone for 5 years and just recently switched to zubzolv. I was taking the 8mg suboxone film, and I am now taking the 8.6 zubzolv. I thought it was gonna be a lot different than taking my suboxone but the zubzolv does me just as good as the subs. I really like the zubzolv – it’s doing great for me.

  5. I have been on Suboxone for 7 years. I started on the strip and then in 1 year I went to the generic pills (Suboxone) for 6 years. Loved them – worked great. Jan 1, 2017 my insurance company won’t pay for subs anymore so had to change to Zubzolv. Within 3 seconds this little pill is gone. But after 1 month now I am finally getting use to them.

    Working good. I am on the 8-6 mg 3 times a day. I like the mint taste too. At first I didn’t think the Zubsolv was going to work… thought I needed more, BUT you and me both know, it’s in our head. Now I am happy being on the Zubsolv, and I know every person is different, but remember it’s in your head.

  6. I’ve been on zubsolv for two years and I’ve switched my insurance to change to the suboxone strips. The zubsolv to be isn’t nearly as effective for my addiction control as the strips are. My state insurance was well care but now I’ve switched to humana caresource in hopes of the strips doing me better. The zubsolv seems to run out faster leaving me feeling a little sick in the evening. I also don’t like the way I get headaches.

  7. Due to the fact that I can’t tell my family or my current Doctor about my past opiate addiction I have to buy buprenorphine from a friend in treatment. If my addiction would come to light I’m sure my doc would pull my current benzodiazepine prescription. I have GAD and severe SAD (general and social anxiety syndrome) I have been diagnosed by a psychiatrist. I would love to tell my family and my doctor but once you are labeled an addict it sticks with you.

    I go to college full time and am constantly around tons of people I don’t know which triggers my anxiety and panic attacks but thank god for my clonazepam or I would not be able to function. Sorry I got off subject a bit but it’s part of my story. The friend who is in a treatment program started out with subutex 8mg, then for a long time was on suboxone strips 8mg/2mg, and now this past month he decided to try zubsolv against my advice.

    The subutex was great but it was tempting to abuse via intranasally. The suboxone was my favorite because I would only take 1mg 2mg tops a day and it can be easily divided into equal parts. Even as small as .5 mg or even .25mg. It really helped me with cravings and with my mood. I’ve heard of suboxone being prescribed off-label for depression and I have to say that there is something to it. I can actually take buprenorphine (any form of the medicine) in place of my anxiety medication on days it isn’t so bad. It keeps me calm, sociable, and stabilizes my mood.

    Now on to the zubsolv. I’ve been doing tons of research about the claims of improved bioavailability. It just doesn’t make sense that two of the exact same drugs are in these medications, but, one claims that since it dissolves faster it has a higher bio. Apparently the buprenorphine molecules in zubsolv are smaller thus making it easier to absorb.

    Plus some citric acid. However the study that claimed zubsolv has a higher bioavailability (5.7mg=8mg?) was funded by Orexa the pharmaceutical company that manufactures zubsolv. I still can’t find the exact availability anywhere just claims of “zubsolv has a higher bioavailability” even on their official website. It took a lot of digging to find anything at all that made it different. All I found was the claim about the smaller molecule size.

    It’s been 3 days so far and I’m going through the zubsolv a lot faster. It’s also a pain in the ass to try to break down those tiny pills into 8 equal pieces. They end up being similar but not exact at all. Plus it’s very time consuming. With suboxone I could fold it and tear it in less than a minute.

    I prefer suboxone strips or subutex > zubsolv. If it was the same amounts of buprenorphine/naloxone then it would be a different story even though dividing the pill up would still be an issue. I wouldn’t feel like I’m getting ripped off of 2.3mgs. Until Orexa releases the exact bioavailability and the method of how it achieves it I think they are just blowing smoke to put less product in and make more money.

    Also way off topic but I wish there was a way to get the treatment myself without the repercussions and stigma that comes with it. Just because your brain is wired to crave and abuse opiates doesn’t mean you will abuse all narcotic substances. I use my anxiety medicine exactly as my doctor tells me to. I screwed up getting hooked on opiates and suboxone is a lifesaver.

    But I need the clonazepam I get to function. Without it I would have never got my AAS and be on my way to getting a BA. I would have had panic attacks and had to run out of the classes and missed them. Without it I’m borderline agoraphobic. I just wish there was a way to get the treatment I need for opiates and not be labeled a universal addict.

    It’s sad I have to get the medicine illegally the way I do putting myself and my friend at risk for getting arrested and being charged even though the chances of that are extremely low. Sorry for getting off topic and the huge post but orexa pharma I just don’t buy it. 5.7 = 8? I don’t think so.

    • Austin… you might as well fess up to your family. The real world gets tougher, after your done with the college gig. Listen, your brain is telling you you’re missing some chemicals. It’s a real medical problem, not some fun time lets get high BS. If your family can’t understand that, I feel for you. Educate them and quit caring with what the world thinks. Garbage. It’s 2018, not 1918… Good luck.

  8. Honestly I’ve been prescribed both and while I don’t see a lot of difference I do think the suboxone strips are a little better than the zubsolv. I have to take 2 zubsolvs to get the same effect as 1 and a half films. Hope this helps someone out there I’m actually getting ready to start felony probation in a couple weeks so they’re not going to allow me to stay on subs. I’ve tried withdrawing from these before it’s pure hell. Wish me luck!!

    • I’m feeling the same way… DEFINITELY NOT EQUAL dosage/feel. Good luck with probation. I can’t believe they won’t let you have prescribed meds that work for you, sucks. What state is that you’re in? NY lets you have subs on probation.

  9. Oh great. I’m supposed to begin taking zubsolv tomorrow that’s if my pharmacy gets the order in. Been taking subs for a year and now state won’t pick up the tab but I saw how expensive the zubs are and so it’ll end up costing the state even more. Somebody was totally blindsided in the office of mental health and hygiene in Baltimore.

  10. I have recently been forced to switch from suboxone to Zubsolv, because I am on state insurance. The state’s reason for this is obvious. Some clown working for Zubsolv claims that the drug can be prescribed in lower doses, but still provide the same results as Suboxone. Hence, the state has to buy less of it meaning that they are saving more money.

    However, I am here to tell you that Zubsolv is not more potent and it is plainly untrue to say that a person requires less of it to obtain the same results as Suboxone. How the clowns at Zubsolv can claim this is amazing to me, because both drugs contain the exact same ratio of active ingredients. Furthermore, since Zubsolv is more expensive the state is going to end up having to pay more for switching, because patients are going to now have to ask to up their dose of Zubsolv from their doctors. Zubsolv Sucks.

  11. First subs now on zubsolv. The zubsolv seems a little weaker meaning I’m not sure about the bioavailability being all that correct but I do know these drugs saved my life. All that matters. After I take one in the morning I feel completely normal and can work, have a family life again, etc. I just wish I would have listened to a few people a few years before and tried them then.

  12. Been on suboxone strips (8mg/2mg) twice daily for going on 3 years if not longer. Insurance switched to Zubsolv beginning this March. I must be different, they feel nothing like the strips. Yes I prefer the taste of Zubsolv but doing the same (1 in morning, 1 in afternoon) as I was for strips, every night after 4 days of switching I get a couple hours sleep then 12am-1am, BANG, instant withdrawal and completely depressed along with every withdrawal symptom there is.

    Even being on the strips I would wake up feeling like dog shit everyday but at least I wasn’t waking up at 1am everyday. Today (yesterday) my primary told me to try taking both doses at the same time in the morning. Same problem. Here it is 3 AM and I’m finally feeling better because I took a Zubsolv. At my lowest point of heroin dependence, an outpatient doctor prescribed me strips (Suboxone).

    Since then, I’m slowly losing everything. They’ve taken my ability to work, I’m constantly tired. Walking up the stairs wears me out! I’m depressed like you wouldn’t believe. Lost all hope, I HATE these drugs. I spent 3 weeks cold turkey 2 years ago off 16mg strips daily and it was pure hell. I am so so afraid of coming off these drugs. I am now classified brain damaged, gaining tons of weight, diabetes, lost CDL and drivers license, living in public assistance and would be homeless if it weren’t for my family supporting me.


  13. I have been taking 8mg Suboxone strips 3 times a day for two years and I have to say though they work really well they take too long to dissolve and they do give headaches. I have tried the generic brand and the strength very week in comparison. I have changed insurance companies and switched to Zubsolv 8.6 – 3 times a day and they are far superior then Suboxone strips with very light side effects. They are much better tasting and dissolve in seconds compared to Suboxone strips that take up to 1/2 hour with the bitter taste still there. Also with Zubsolv I don’t need a pre-auth for approval.

  14. I have been new to the whole suboxone…use…and treatment plan. I have been on subs for three weeks and all I have gotten is the worst headache and still had many withdrawals symptoms.. Body aches, tiredness, awful taste in mouth,increased dry mouth, and no energy just sleepy. The doctor thought I should try zubsolv…

    I asked why she said it doesn’t have that taste and dissolves in mins. I said that alone will make me feel better. I would have the worst anxiety every time I took a sub… Because the taste was so nasty and took so long. With zubsolv…the taste is minty and a little sparky under the tongue but gone within minutes… And it starts to work much faster than subs… I feel more alert, still have muscle aches but think I need a stronger dose.

    I also found with subs I would grind my teeth and have such a bad taste in my mouth for hours and days… Not with zubsolv. Everyone is different and reacts different to every med. But I think zubsolv is twenty times better than subs. No anxiety about taste. No headache. Couldn’t tell you how bad subs headaches were…ugh. It’s only the beginning to a long road. But at least I can tolerate the treatment.

    • The taste different is negligible to me. However, after taking suboxone for over 5 years and now switching to Zubsolv (due to insurance coverage issues), I am extremely fatigued during the day with a slight nausea/dizziness as well. I have been on it for two weeks but as yet my body hasn’t adjusted. I do not believe this is a placebo effect as I fully expected the drug to be identical to suboxone and I had read nothing about it before taking it.

      • Are you on the Equivalent Dose? I’m currently trying to fight with my insurance company who is trying to force me to go on Generic Suboxone after being on the name brand for 5 years as well. I was considering going on Zubsolv instead, but if you’re having problems I wonder if I’d have the same or not..


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