Mental Health DailyResearch. Evidence. Perspective.Published research on treatment-resistant depression.
Researchers aimed repetitive transcranial magnetic stimulation (rTMS), which uses magnetic pulses to stimulate brain cells, at a spot chosen from each person’s own brain scan. In a small Col…
Read articleA 7-trial review favored adding celecoxib to antidepressants for depression, but its benefit was not confirmed after 3 high-risk trials were excluded.
Read articleAdding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participan…
Read articleA 2026 medRxiv preprint reported that an at-home subcallosal cingulate cortex deep brain stimulation (SCC DBS) recording system could track stable recovery in severe treatment-resistant depr…
Read articleA 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmac…
Read articleA 2026 multimodal MRI study found that treatment-resistant depression had lower coordination between brain structure and brain activity than non-treatment-resistant depression in frontal, pa…
Read articleIntranasal esketamine — FDA-approved for treatment-resistant depression in 2019 — failed cost-effectiveness benchmarks against four cheaper third-line options in a 2026 Hong Kong modeling st…
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