A 2025 Nature Aging study found that hippocampal ferritin light chain 1 (FTL1) rose with age in mouse neurons, tracked poorer cognition, and became experimentally reversible in old mice. This is an animal-mechanism result, not a human anti-aging treatment.1 Research Highlights FTL1 rose in aged hippocampus: Western blot data showed higher hippocampal FTL1 in aged …
A Nature Communications study found that old vertebrate brains lost almost 40% of cysteine protease deubiquitylase catalytic activity with age, despite relatively stable protein abundance.1 Antioxidant treatment with NACET restored DUB activity in aging brains, making the finding a reversible enzyme-mechanism result rather than a generic “antioxidants reverse brain aging” claim. Research Highlights DUB activity …
A 2026 mouse and cell study found that ATP11B loss pushed aged brains toward hippocampal iron accumulation, mitochondrial dysfunction, neuronal ferroptosis, and worse memory behavior than wild-type comparison mice; ATP11B overexpression then improved multiple learning and memory tests in 18-month-old mice. Research Highlights Memory signal: ATP11B-deficient mice performed worse than wild-type mice on Morris water …
A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …
Chronic low-grade inflammation rises with age, and a growing body of work asks whether peripheral inflammatory markers in blood track subtle changes in brain white-matter microstructure on MRI. A 2026 preprint from the Healthy Minds for Life cohort by Mishra and colleagues at Johns Hopkins examined 457 dementia-free adults aged 50–79 and found that higher …
Anyone living in a big city that has taken a vacation to experience nature (e.g. a cabin in the woods) can often detect a stark contrast in air quality. In the big city, the air you’re breathing in often smells dull and polluted, and you may sense that it’s taking a toll on your health. …