Mental Health DailyResearch. Evidence. Perspective.Published research on autophagy.
A 2026 neuron and mouse study found that CB1 receptors accumulate when autophagic flux is blocked, but p62 deficiency did not significantly increase steady-state CB1 receptor abundance in br…
Read articleA 2026 review ties the Parkinson’s disease genes PINK1 and parkin to damaged-mitochondria cleanup, from damage sensing and ubiquitin tagging to autophagy recruitment and lysosomal degradatio…
Read articleA human, mouse, and zebrafish study linked long-term chlorpyrifos exposure to Parkinson’s disease risk, with the strongest exposure-duration estimate reaching OR 2.74 for workplace proximity…
Read articleA 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal channel relevant to Parkinson’s risk biology.1 Acidifying the luminal side from pH 7.4 to 4.7 activated proton conduc…
Read articleA 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH in APP695Swe neuronal cells from 5.6 back below 5.0, then reduced amyloid-β, MAPT/tau pathology, neuron…
Read articleDepression is a pervasive mental health issue with complex origins and often inadequate treatment options. Recent studies have suggested that mitophagy, the process of selective mitochondria…
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