MentalHealthDaily

NDST3 Suppression Restores Lysosome Acidity in Alzheimer’s Mouse Models

by GLOOM

MHD featured image for NDST3 suppression and lysosomal acidification in Alzheimer's disease models.

A 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH in APP695Swe neuronal cells from 5.6 back below 5.0, then reduced amyloid-β, MAPT/tau pathology, neuronal injury, and memory deficits in 3xTg-AD mice.1 Research Highlights Lysosome pH moved back down: APP695Swe-overexpressing HT22 cells had lysosomal pH around 5.6, while NDST3 knockdown re-acidified lysosomes to …

Mitophagy & Depression: Mitochondrial Autophagy as an Antidepressant Target?

by GLOOM

Depression is a pervasive mental health issue with complex origins and often inadequate treatment options. Recent studies have suggested that mitophagy, the process of selective mitochondrial autophagy, plays a crucial role in the onset and progression of depression, offering new insights into its pathogenesis and potential treatments. Highlights: Major Depressive Disorder (MDD) affects millions globally, …