A 2,251-child national parent-report preprint found that the 7-item Parent-report Nationwide Quality of Life Scale had internal reliability of alpha = 0.85 and correlated most strongly with suicidality (r = -0.50), depression (r = -0.47), and internalizing symptoms (r = -0.43).1 Research Highlights Reliability was solid for a brief scale: the 7-item parent P-NQLS showed …
A 2026 ENIGMA-OCD preprint tested a transformer model on resting-state fMRI from 1,706 participants and reached AUROC = 0.653 ± 0.039 for OCD classification.1 The more important result was the failure mode: held-out-site performance ranged from AUROC 0.427 to 0.819, which is exactly the gap clinical AI has to close before brain-scan diagnosis is credible. …
A 2026 Add Health analysis found that combining major-depression and alcohol-use-disorder polygenic scores added 4.88% variance for comorbid MDD-AUD prediction, while same-trait scores added only 0.65% for MDD and 1.52% for AUD alone.1 The genetic signal is strongest where the clinical problem is hardest: depression plus alcohol-use disorder, not either diagnosis in isolation. Research Highlights …
A 2026 preprint involving 31 children and adolescents treated for medulloblastoma found that silent verb-generation fMRI separated pre- from post-radiotherapy scans with 80.7% leave-one-subject-out accuracy (p = 0.0149).1 The signal points to early cerebellar-cerebral language-network change, not yet to a proven long-term cognitive endpoint. Research Highlights Classifier performance was above chance: A linear support-vector machine …
A 2026 longitudinal study involving 951 adolescents found 5 emotion-regulation profiles, not the 3-profile structure the researchers expected, and the clearest mental-health separation came from the adaptive and maladaptive profiles.1 Teen coping looked less like a single good-versus-bad scale and more like a pattern of motives, strategies, and beliefs about whether those strategies work. Research …
A 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical societal cost reductions (−€2,589 vs. −€2,602), while cost-effectiveness probabilities were only 46% to 59% at trial level but exceeded 80% in the UK.1 The algorithm signal was country-specific and capability-weighted, …
A 2026 Australian study involving 2,192 dementia-free adults found that each 10% higher ultra-processed food intake was associated with 0.05-point lower attention and 0.24-point higher modified CAIDE dementia-risk score.1 The memory result was not significant, so the honest read is attention and risk-score signal, not global cognitive collapse. Research Highlights Attention was lower: Each 10% …