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AVATAR Therapy Reduced Auditory Hallucination Severity in 8 Trials

MHD featured image for AVATAR therapy and auditory hallucinations.

A 2026 meta-analysis of 8 controlled trials found that AVATAR therapy reduced auditory verbal hallucination severity after treatment, Hedges’ g = −0.40, 95% CI −0.54 to −0.25, across 978 participants.1 The signal is real, but the strongest reading is short-term symptom calibration rather than a finished replacement for standard psychosis care. Research Highlights Voice severity …

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Mental Health AI Agents: 0.80 Sensitivity, Weak Real-World Evidence

Mental-health AI agents are software systems that use artificial intelligence to screen, coach, triage, document, or coordinate care across mental-health workflows. A 2026 systematic review and meta-analysis of systems published from 2023 to 2025 found strong offline diagnostic metrics, but the evidence still leans much more heavily on chatbot demos and benchmark tasks than on …

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NOS3 TT Variant Linked to 1.72x Cognitive Risk in First-Episode Depression

A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …

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Psychopathy, Empathy, and Cortical Structure in 804 Incarcerated Men

Psychopathy is not a simple “low empathy equals abnormal brain scan” story. In 804 incarcerated men, psychopathy factors tracked empathic concern, perspective taking, cortical thickness, surface area, and cortical organization—but self-reported empathy scores did not map cleanly onto cortical structure.1 Research Highlights The sample was unusually large for forensic MRI. Radecki et al. analyzed 804 …

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Cancer Survivor Neuropathic Pain: Duloxetine and Exercise Signals

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A 2026 scoping review screened 956 systematic reviews/guidelines and 604 original studies on cancer-survivor neuropathic pain, but only 11 pharmacological, 2 psychological, and 3 exercise studies were eligible.1 The practical signal is narrow: duloxetine and some exercise programs have the clearest support, while psychological and interdisciplinary evidence is still too thin for confident treatment ranking. …

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Prenatal PM2.5 Linked to Autism-Relevant Newborn Amino Acid Metabolism

MHD featured image for prenatal air pollution, newborn metabolomics, and autism risk.

A matched case-control study of 50 children with autism spectrum disorder and 50 controls found that newborn amino acid metabolism overlapped with both later autism diagnosis and prenatal air-pollution exposure.1 The central pathway, aspartate and asparagine metabolism, was associated with autism (p = 0.01), pregnancy PM2.5 (p < 0.001), first-trimester PM2.5 (p < 0.001), and …

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