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Drugs

Cognitive Enhancement Effects of Caffeine, Methylphenidate, Modafinil (Study)

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In the pursuit of peak mental performance, scientific studies have explored the effects of stimulants like methylphenidate, modafinil, and caffeine on cognitive functions such as memory and attention. Recent research utilizing advanced neuroimaging techniques has begun to unravel the intricate ways these substances modulate brain activity and connectivity, offering insights into their potential as cognitive …

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Analyzing Cardiovascular Effects & Risks of Newer Antidepressants

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Depression is a prevalent and serious condition in older adults and those with cardiovascular disease. Serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression, but when they’re ineffective, alternative antidepressants must be considered. Key Facts: Depression in Older Adults and Cardiovascular Patients: Affects 15-20% of patients with coronary heart disease. Limitations of SSRIs: While …

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Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

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Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …

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Marijuana Abuse & Early-Onset Frontotemporal Dementia: 34-Year-Old Male (Case Report)

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A 34-year-old man developed symptoms of frontotemporal dementia (FTD), a rare form of early-onset dementia, after using cannabis for two years. This case highlights the potential risks of long-term cannabis use on brain health, especially for vulnerable individuals. Key Facts: The 34-year-old man used cannabis for two years before experiencing personality changes and behavioral symptoms …

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Semaglutide & Empagliflozin May Treat Obesity-Related Cognitive Impairment (Mouse Study)

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Obesity now affects over 650 million adults globally and is a major risk factor for various chronic diseases including cognitive decline and impairment. Recent evidence shows a link between obesity, reduced brain volume and neuronal loss, increased dementia risk, and impaired learning, memory and cognition. Preliminary evidence suggests that weight loss drugs like semaglutide may …

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Moon Rock Weed (Marijuana): Psychosis & Seizures in 20-Year-Old Male (Case Report)

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Cannabis use is associated with neurological and psychiatric side effects, but the risks of highly potent forms like “moon rocks” are not fully characterized. This case report describes psychosis and new-onset seizures in a 20-year-old following the first-time use of this THC-concentrated preparation. Key Facts: Moon rock cannabis contains high levels of THC, which acts …

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