A 2026 mechanistic study involving 28 healthy adults found that a single 25 mg psilocybin session changed acute brain entropy, psychological insight, well-being, cognitive flexibility, and some MRI-derived white-matter signals for up to 1 month. Research Highlights Acute brain entropy rose clearly: 25 mg psilocybin increased Lempel-Ziv complexity (LZc; a measure of signal irregularity) at …
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores showed distinct resting facial action-unit patterns: AU10 upper lip raiser, AU23 lip tightener, and AU28 lip suck differed after correction in 45 analyzable participants.1 The result supports facial-expression screening research, but it does not show that a face video can diagnose MCI or …
A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy young adults, healthy older adults, and Parkinson’s disease patients, p = 0.0032, while gamma efficiency-sympathetic coupling differed at p = 0.0003.1 The main claim is that motor, cognitive, and autonomic physiology may be coupled tightly enough to deserve biomarker-level study. Research Highlights Brain-heart …
A 2026 Nature single-neuron study recorded 3,109 medial temporal lobe neurons from 16 neurosurgical epilepsy patients and found that human item-context memory mostly used separate item and context populations: 597 stimulus-modulated neurons, 200 context-modulated neurons, and only 50 neurons that encoded specific picture-question combinations.1 The result argues against a simple “one cell stores the whole …
A 2026 medicinal-chemistry study found that thymol carbamate TC-6 inhibited human butyrylcholinesterase at 3.6 nM, showed more than 2,500-fold selectivity over human acetylcholinesterase, crossed a blood-brain-barrier screening assay, and improved spatial-memory behavior in amyloid-β-injected mice. Research Highlights TC-6 hit BuChE hard: Wu et al. reported human butyrylcholinesterase (BuChE) inhibition at 3.6 nM, compared with 9,320 …
A 2026 Journal of Neuroinflammation study involving 33 people with multiple sclerosis and 10 healthy controls found disease-specific B-cell repertoire signatures even when ordinary B-cell subset counts looked modest, then showed that most disease-modifying therapies shifted repertoire diversity after 6 months. Research Highlights Repertoire sequencing found MS signal: Vasilenko et al. analyzed more than 196,100,000 …
A 2026 Nature study found that parasite-sensing tuft cells can release acetylcholine, activate crypt enterochromaffin cells through muscarinic receptors, trigger serotonin release, stimulate vagal afferent neurons, and suppress food intake during established infection.1 The finding is a precise gut-defense circuit, not a generic claim that the gut-brain axis explains every mood or appetite problem. Research …